2-Chloro-4,5-bis(4-methoxyphenyl)pyrimidine | 375793-09-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-Chloro-4,5-bis(4-methoxyphenyl)pyrimidine
• CAS: 375793-09-2
• 化学式: C₁₈H₁₅ClN₂O₂
• 分子量: 326.782
• InChiKey: CBZZLMYBFGPHTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  氰化钾 、 2-Chloro-4,5-bis(4-methoxyphenyl)pyrimidine 在 四(三苯基膦)钯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以60%的产率得到4,5-Bis(4-methoxyphenyl)pyrimidine-2-carbonitrile
  参考文献：
  名称：

  Synthesis and bioactivities of novel pyridazine derivatives: inhibitors of interleukin-1 beta (IL-1β) production

  摘要：

  New pyridazine derivatives were prepared, and their abilities to inhibit IL-1 beta production were evaluated. Some compounds showed potent inhibitory activity against IL-1 beta production in HL-60 cells stimulated with lipopolysaccharide (LPS). The synthesis and structure-activity relationships of these compounds are described. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00432-2
• 作为产物：
  描述：

  在 五氯化磷 、 三氯氧磷 作用下， 以57%的产率得到2-Chloro-4,5-bis(4-methoxyphenyl)pyrimidine
  参考文献：
  名称：

  Synthesis and bioactivities of novel pyridazine derivatives: inhibitors of interleukin-1 beta (IL-1β) production

  摘要：

  New pyridazine derivatives were prepared, and their abilities to inhibit IL-1 beta production were evaluated. Some compounds showed potent inhibitory activity against IL-1 beta production in HL-60 cells stimulated with lipopolysaccharide (LPS). The synthesis and structure-activity relationships of these compounds are described. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00432-2