1-Amino-3-(4-iodophenyl)urea | 73469-90-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Amino-3-(4-iodophenyl)urea
• CAS: 73469-90-6
• 化学式: C₇H₈IN₃O
• 分子量: 277.065
• InChiKey: UJGWYDJNDZUYMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苯草灭 、 1-Amino-3-(4-iodophenyl)urea 在 溶剂黄146 作用下， 反应 4.0h， 以49%的产率得到1-(4-iodo-phenyl)-3-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-urea
  参考文献：
  名称：

  一些新的生物活性1-（4-取代-苯基）-3-（4-氧代-2-苯基/乙基-4 H-喹唑啉-3-基）-脲的合成，抗惊厥和中枢神经系统抑制活性

  摘要：

  合成了几种新的1-（4-取代-苯基）-3-（4-氧代-2-苯基/乙基-4 H-喹唑啉-3-基）-脲，并筛选了抗惊厥药，中枢神经系统抑制剂和镇静催眠活性。在老鼠身上。经腹腔注射小鼠30、100和300 mg / kg体重后，在小鼠的最大电击诱发癫痫发作（MES）和皮下戊四氮（scPTZ）诱发癫痫发作模型中检查合成的化合物。光谱数据和元素分析与新合成的化合物一致。使用转子法评估神经毒性。化合物E1，E6，E9，E12，P3，P4和P6被发现在MES屏幕中处于活动状态，而E1，P4，P6和P11在scPTZ屏幕中处于活动状态。通过光度光度计筛选，在施用化合物1小时后，除E6，E11和P6外，所有其他化合物的运动活性均降低了50％以上。借助强制游泳法筛选的中枢神经系统抑制剂活性产生了一些有效的化合物。如增加的固定时间所表明，发现所有化合物均表现出有效的CNS抑制剂活性。可以得出结论，新合成的化合物具有有前途的中枢神经系统活性。

  DOI：

  10.1016/j.ejmech.2009.05.008
• 作为产物：
  描述：

  phenyl (4-iodophenyl)carbamate 在 一水合肼 作用下， 以 乙二醇二甲醚 为溶剂， 反应 24.0h， 生成 1-Amino-3-(4-iodophenyl)urea
  参考文献：
  名称：

  Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism

  摘要：

  The incidence of life-threatening fungal infections is increasing dramatically. In an attempt to develop novel antifungal agents, our previously synthesized phenoxyalkylpiperazine triazole derivatives were used as lead structures for further optimization. By means of structure-based bioisosterism, triazolone was used as a new bioisostere of oxygen atom. This type of bioisosteric replacement can improve the water solubility without loss of hydrogen-bonding interaction with the target enzyme. A series of triazolone-containing triazoles were rationally designed and synthesized. As compared with fluconazole, several compounds showed higher antifungal activity with broader spectrum, suggesting their potential for further evaluations. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.03.019

文献信息

• Hydrazide and alkoxyamide angiogenesis inhibitors
  申请人：——

  公开号：US20020002152A1

  公开（公告）日：2002-01-03

  Compounds having the formula 1 are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.

  具有以下化学式的化合物是蛋氨酸氨肽酶2型（MetAP2）抑制剂，对抑制血管生成有用。还公开了抑制MetAP2的组合物和在哺乳动物中抑制血管生成的方法。
• Novel 1,2,3,4-tetrahydroisoquinoline, their preparation method and their use as fungicides
  申请人：——

  公开号：US20030187267A1

  公开（公告）日：2003-10-02

  The invention concerns compounds of formula (I) wherein: p=1 or 2; X, X 1 and X 2 represent N or CH═; R 1 , R 2 , R 3 , R 4 , R 5 and R 6 represent a hydrogen atom, a halogen atom, alkyl, O-alkyl, S—(O) n alkyl, alkenyl, O-alkenyl, S—(O) n alkenyl, alkynyl, O-alkynyl, S—(O) n alkynyl; n=0, 1 or 2, or NO 2 , NH 2 or C═N or R 1 , R 2 , R 3 or R 5 , R 6 form a cycle, or R 4 A can be cycloalkyl, heterocycle, aryl, O-aryl or oxygenated or nitrogenated chain; R 7 represents H, OH, SO 3 H or OPO(OH) 2 ; A and B=hydrogen or oxygenated or nitrogenated chain; C and D=hydrogen, halogen or alkyl or together form with the carbons bearing them a cycle. The compounds of formula (I) have antifungal properties.

  本发明涉及公式(I)的化合物，其中：p＝1或2；X、X1和X2代表N或CH；R1、R2、R3、R4、R5和R6代表氢原子、卤素原子、烷基、O-烷基、S-(O)n烷基、烯基、O-烯基、S-(O)n烯基、炔基、O-炔基、S-(O)n炔基；n＝0、1或2，或NO2、NH2或CnHn或R1、R2、R3或R5、R6形成一个环，或R4A可以是环烷基、杂环、芳基、O-芳基或含氧或含氮链；R7代表H、OH、SO3H或OPO(OH)2；A和B＝氢或含氧或含氮链；C和D＝氢、卤素或烷基，或与它们所带的碳形成一个环。公式(I)的化合物具有抗真菌作用。
• [EN] HYDRAZIDE AND ALKOXYAMIDE ANGIOGENESIS INHIBITORS<br/>[FR] INHIBITEURS D'ANGIOGENESE A BASE D'HYDRAZIDE ET D'ALCOXYAMIDE
  申请人：ABBOTT LAB

  公开号：WO2001079157A1

  公开（公告）日：2001-10-25

  Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.

  具有公式的化合物是蛋氨酸氨肽酶2型（MetAP2）抑制剂，并且对于抑制血管生成具有用处。还披露了MetAP2抑制剂组合物和在哺乳动物中抑制血管生成的方法。
• Design, synthesis, and potential CNS activity of some new bioactive 1-(4-substituted-phenyl)-3-(4-oxo-2-methyl-4H-quinazolin-3-yl)-urea
  作者：Sushil K. Kashaw、Varsha Kashaw、Pradeep Mishra、N. K. Jain、J. P. Stables

  DOI：10.1007/s00044-010-9362-x

  日期：2011.7

  Twelve new 1-(4-substituted-phenyl)-3-(4-oxo-2-methyl-4H-quinazolin-3-yl)-urea were synthesized and screened for anticonvulsant, CNS depressant, and sedative-hypnotic activity. After i.p. injection to mice at doses of 30, 100, and 300 mg/kg body weight 2,3-Disubstituted-quinazolin-4(3H)-one were examined in the maximal electroshock-induced seizures (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure models in mice. Spectroscopic data and elemental analysis were consistent with the newly synthesized compounds. The neurotoxicity was assessed using the rotorod method. M3, M4, and M10 were found to be active in both MES screen and scPTZ screen at 0.5 h. All except M11 showed more than 44% decrease in locomotor activity after 1 h of compound administration via actophotometer screen. CNS-depressant activity screened with the help of the forced swim method resulted into some potent compounds. Except for M6 and M11 other tested compounds were found to exhibit potent CNS depressants activity as indicated by increased immobility time. It can be concluded that newly synthesized compounds possessed sedative-hypnotic and CNS depressant activities.
• Kramer, Claus-Ruediger; Beck, Lothar, Zeitschrift fur Chemie, 1980, vol. 20, # 1, p. 25 - 26
  作者：Kramer, Claus-Ruediger、Beck, Lothar

  DOI：——

  日期：——