N-(4-hydroxybenzoyl)-(6H)phenanthridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-(4-hydroxybenzoyl)-(6H)phenanthridine
• 英文别名: (4-hydroxyphenyl)-(6H-phenanthridin-5-yl)methanone
• 化学式: C₂₀H₁₅NO₂
• 分子量: 301.345
• InChiKey: ZYEWWAAIWBNAMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-碘苯甲醛 在 palladium dihydroxide potassium acetate 、 三乙酰氧基硼氢化钠 、 溶剂黄146 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基乙酰胺 、 1,2-二氯乙烷 为溶剂， 生成 N-(4-hydroxybenzoyl)-(6H)phenanthridine
  参考文献：
  名称：

  Direct Arylation Reactions Catalyzed by Pd(OH)₂/C:  Evidence for a Soluble Palladium Catalyst

  摘要：

  Palladium hydroxide on carbon (Pearlman's catalyst) effectively catalyzes direct arylation reactions of aryl iodides and bromides, providing excellent arylation-to-hydrodehalogenation ratios (> 30:1) with broad scope for both intra- and intermolecular arylation processes. Studies aimed at determining the nature of the active catalyst indicate that an active homogeneous palladium species is produced under the reaction conditions.

  DOI：

  10.1021/jo051039v

文献信息

• Direct Arylation Reactions Catalyzed by Pd(OH)₂/C:  Evidence for a Soluble Palladium Catalyst
  作者：Mathieu Parisien、Damien Valette、Keith Fagnou

  DOI：10.1021/jo051039v

  日期：2005.9.1

  Palladium hydroxide on carbon (Pearlman's catalyst) effectively catalyzes direct arylation reactions of aryl iodides and bromides, providing excellent arylation-to-hydrodehalogenation ratios (> 30:1) with broad scope for both intra- and intermolecular arylation processes. Studies aimed at determining the nature of the active catalyst indicate that an active homogeneous palladium species is produced under the reaction conditions.