2-(8-bromooctyloxy)-4-[N,N-bis(4-formyl-phenyl)]aminobenzaldehyde | 1025900-61-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(8-bromooctyloxy)-4-[N,N-bis(4-formyl-phenyl)]aminobenzaldehyde
• 英文别名: 2-(8-bromooctyloxy)-4-[N,N-bis(4-formylphenyl)amino]benzaldehyde；2-(8-bromooctoxy)-4-(4-formyl-N-(4-formylphenyl)anilino)benzaldehyde
• CAS: 1025900-61-1
• 化学式: C₂₉H₃₀BrNO₄
• 分子量: 536.466
• InChiKey: UCIMJPFGWVBUOL-UHFFFAOYSA-N

物化性质

• 熔点：
  80 °C
• 沸点：
  680.4±55.0 °C(Predicted)
• 密度：
  1.313±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  35
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  diethyl (1,3-benzothiazol-2-ylmethyl)phosphonate 、 2-(8-bromooctyloxy)-4-[N,N-bis(4-formyl-phenyl)]aminobenzaldehyde 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 24.25h， 以75%的产率得到(E,E,E)-3-(8-bromooctyloxy)-4-(2-(benzothiazol-2-yl)vinyl)-N,N-bis(4-(2-(benzothiazol-2-yl)vinyl)phenyl)aniline
  参考文献：
  名称：

  Triphenylamine derivatives useful as fluorophores in biology, in particular for two-photon microscopy

  摘要：

  三苯胺衍生物在生物学中作为荧光物质特别有用，特别适用于双光子显微镜；以及包含这些衍生物的组合物，用于标记生物分子（或“生物分子”），如核酸、寡核苷酸、蛋白质、多肽、质粒等，特别是通过双光子显微镜进行检测，并用于标记了上述衍生物的生物分子。

  公开号：

  US08664400B2
• 作为产物：
  描述：

  2-甲氧基-4-氨基苯甲酸甲酯 在 manganese(IV) oxide 、 aluminum (III) chloride 、 lithium aluminium tetrahydride 、 三叔丁基膦 、 palladium diacetate 、 potassium carbonate 、 caesium carbonate 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 、 丙酮 、 甲苯 为溶剂， 反应 114.0h， 生成 2-(8-bromooctyloxy)-4-[N,N-bis(4-formyl-phenyl)]aminobenzaldehyde
  参考文献：
  名称：

  Triphenylamine derivatives useful as fluorophores in biology, in particular for two-photon microscopy

  摘要：

  三苯胺衍生物在生物学中作为荧光物质特别有用，特别适用于双光子显微镜；以及包含这些衍生物的组合物，用于标记生物分子（或“生物分子”），如核酸、寡核苷酸、蛋白质、多肽、质粒等，特别是通过双光子显微镜进行检测，并用于标记了上述衍生物的生物分子。

  公开号：

  US08664400B2

文献信息

• Synthetic Strategies to Derivatizable Triphenylamines Displaying High Two-Photon Absorption
  作者：Rémy Lartia、Clémence Allain、Guillaume Bordeau、Falk Schmidt、Céline Fiorini-Debuisschert、Fabrice Charra、Marie-Paule Teulade-Fichou

  DOI：10.1021/jo702002y

  日期：2008.3.1

  [Graphics]A versatile synthetic strategy to access a set of highly fluorescent g-conjugated triphenylamines bearing a functional linker at various positions on one phenyl ring is described. These compounds were designed for large two-photon absorption (2PA) and in particular for labeling of biomolecules. The monoderivatized trisformylated or trisiodinated intermediates described herein allow introduction of a large variety of electron-withdrawing groups required for large 2PA as well as a panel of chemical functions suitable for coupling to biomolecules. The monoderivatized three-branched compounds and in particular the benzothiazole JP-3Bz) series show remarkable linear (high extinction coefficients and high quantum yield) and nonlinear (high 2-photon cross sections) optical properties. Interestingly the presence of functional side chains does not disturb the two-photon absorption. Finally, monoderivatized two-branched derivatives also appear to be valuable candidates. Altogether the good optical properties of the new derivatizable pi-conjugated TPA combined with their small size and their compatibility with bioconjugation protocols suggest that they represent a new chemical class of labels potentially applicable for the tracking of biomolecules using two-photon scanning microscopy.
• Triphenylamine derivatives useful as fluorophores in biology, in particular for two-photon microscopy
  申请人：Allain Clémence

  公开号：US08664400B2

  公开（公告）日：2014-03-04

  Triphenylamine derivatives useful as fluorophores in biology, in particular for two-photon microscopy; and compositions comprising these derivatives, to the use of these compositions and of the derivatives themselves for labelling biological molecules (or “biomolecules”) such as nucleic acids, oligonucleotides, proteins, polypeptides, plasmids, and the like, for their examination in particular by two-photon microscopy, and to biomolecules labelled with the said derivatives.

  三苯胺衍生物在生物学中作为荧光物质特别有用，特别适用于双光子显微镜；以及包含这些衍生物的组合物，用于标记生物分子（或“生物分子”），如核酸、寡核苷酸、蛋白质、多肽、质粒等，特别是通过双光子显微镜进行检测，并用于标记了上述衍生物的生物分子。