Diethyl 3-(2-methoxyacetyl)oxypentanedioate | 483299-14-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Diethyl 3-(2-methoxyacetyl)oxypentanedioate
• CAS: 483299-14-5
• 化学式: C₁₂H₂₀O₇
• 分子量: 276.287
• InChiKey: IWNFSRZUHOPDJB-UHFFFAOYSA-N

物化性质

• 沸点：
  274.0±25.0 °C(Predicted)
• 密度：
  1.133±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  88.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Diethyl 3-(2-methoxyacetyl)oxypentanedioate 在 sodium hydroxide 、 草酰氯 、 N,N-二甲基甲酰胺 、 α-chymotrypsin 作用下， 以 phosphate buffer 、 水 为溶剂， 生成 ethyl (3S)-5-chloro-3-(2-methoxyacetyl)oxy-5-oxopentanoate
  参考文献：
  名称：

  Oehrlein; Baisch, Gabriele, Advanced Synthesis and Catalysis, 2003, vol. 345, # 6-7, p. 713 - 715

  摘要：

  DOI：
• 作为产物：
  描述：

  3-羟基戊二酸二乙酯 、 甲氧基乙酰氯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 以97%的产率得到Diethyl 3-(2-methoxyacetyl)oxypentanedioate
  参考文献：
  名称：

  Oehrlein; Baisch, Gabriele, Advanced Synthesis and Catalysis, 2003, vol. 345, # 6-7, p. 713 - 715

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF 3-HYDROXY-GLUTARIC ACID MONOESTERS AND USE THEREOF<br/>[FR] PROCÉDÉ DE SYNTHÈSE ÉNANTIOSÉLECTIVE DE MONOESTERS DE L'ACIDE 3-HYDROXY-GLUTARIQUE ET UTILISATION
  申请人：SANDOZ AG

  公开号：WO2014140006A1

  公开（公告）日：2014-09-18

  The present invention relates to a process for the enzymatic enantioselective synthesis of 3-hydroxy- glutaric acid esters of formula 1 with R 1being alkyl, aryl, or substituted alkyl, as well as the use compounds of formula 1 in the synthesis.

  本发明涉及一种用酶催化的对映选择性合成3-羟基戊二酸酯的方法，所述酯的化学式为1，其中R1为烷基、芳基或取代烷基。同时，本发明还涉及使用化合物1在合成中的应用。
• Process for the preparatiom of 7-amino-syn-3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation
  申请人：BASF SE

  公开号：EP2161250A1

  公开（公告）日：2010-03-10

  Synthesis and intermediates The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra' and Rc' are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XVI wherein Ra' and Rc' are each independently of the other hydrogen or a hydroxy-protecting group, R* and R** are each independently of the other hydrogen or an amide-protecting group, and Rb is a carboxy-protecting group; which methods proceed to further new intermediates and methods for their preparation.

  合成和中间体 本发明涉及制备适用于制备他汀衍生物的中间体的新型合成方法，尤其涉及式 VI 中间体的新型合成方法 其中，Ra'和 Rc'各自独立地为氢或羟基保护基团，或共同为桥接羟基保护基团，Rb 为羧基保护基团，这些方法通过式 XVI 中间体的转化来实现 其中，Ra'和 Rc'各自独立地为氢或羟基保护基团，R*和 R** 各自独立地为氢或酰胺基保护基团，Rb 为羧基保护基团；通过这些方法可进一步制备新的中间体及其制备方法。
• Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3 5-dihydroxy heptanoic acid derivatives, and intermediates thereof
  申请人：——

  公开号：US20040186313A1

  公开（公告）日：2004-09-23

  The invention relates to synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or N(CH 3 )OCH 3 , R a is a hydroxy-protecting group, and R b is a carboxy-protecting group, and, as well as to the compound of formula I, to further intermediates and methods for their preparation by Friedel-Crafts acylation. 1

  本发明涉及制备他汀衍生物的合成方法，该方法通过式 I 的关键中间体进行，其中 X 为卤素、酰氧基、活化的烃氧基、活化的烃硫基或 N（CH 3 ) OCH 3 , R a 是羟基保护基团，而 R b 是羧基保护基团，以及式 I 所示化合物的进一步中间体和通过 Friedel-Crafts 酯化反应制备它们的方法。 1
• Process for preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation
  申请人：——

  公开号：US20040242916A1

  公开（公告）日：2004-12-02

  The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein R a ′ and R c ′ are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and R b is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XVI wherein R a ′ and R c ′ are each independently of the other hydrogen or a hydroxy-protecting group, R* and R** are each independently of the other hydrogen or an amide-protecting group, and R b is a carboxy-protecting group; which methods proceed to further new intermediates and methods for their preparation. 1

  本发明涉及制备适用于制备他汀衍生物的中间体的新型合成方法，尤其涉及式 VI 中间体的新型合成方法，其中 R a 和 R c ′各自独立地为氢或羟基保护基团，或共同为桥接羟基保护基团，而 R b 是羧基保护基团，这些方法是通过式 XVI 中间体的转化进行的，其中 R a 和 R c ′各自独立地为氢或羟基保护基团，R*和 R** 各自独立地为氢或酰胺保护基团，R b 是一个羧基保护基团；这些方法进而进一步得到新的中间体及其制备方法。 1
• Pyrrole synthesis
  申请人：Ohrlein Reinhold

  公开号：US20050014954A1

  公开（公告）日：2005-01-20

  The invention relates to a novel process for the preparation of N-substituted pyrroles, especially of formula (V), wherein the radicals are as defined in the description, by intermolecular aza-Wittig reaction starting from organic azides and 1,4-dioxo compounds. The invention relates also to novel iminophosphorane intermediates for this synthesis. The resulting pyrroles are useful, for example, in the organic synthesis of pharmaceuticals or other active substances and chemicals.

  本发明涉及一种以有机叠氮化物和 1,4-二氧代化合物为起点，通过分子间偶氮-维蒂希反应制备 N-取代的吡咯，特别是式 (V)，其中自由基如描述中所定义。本发明还涉及用于这种合成的新型亚氨基磷烷中间体。由此得到的吡咯类化合物可用于医药或其他活性物质和化学品的有机合成。