1-[(2R,3R,4R,5R)-3-(anthracen-2-ylmethoxy)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione | 173034-68-9

• 分子结构分类: 有机化合物
• 英文名称: 1-[(2R,3R,4R,5R)-3-(anthracen-2-ylmethoxy)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• CAS: 173034-68-9
• 化学式: C₂₄H₂₂N₂O₆
• 分子量: 434.448
• InChiKey: NDKPIYGXRVMVJY-JMJGKCIBSA-N

物化性质

• 密度：
  1.48±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-[(2R,3R,4R,5R)-3-(anthracen-2-ylmethoxy)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione 、 alkaline earth salt of/the/ methylsulfuric acid 生成
  参考文献：
  名称：

  Oligonucleotides having covalently linked anthracene at specific sugar residue: Differential binding to DNA and RNA and fluorescence properties

  摘要：

  Oligonucleotide 15 -mers containing 2-anthracenylmethyl groups at specific sugar residues have been synthesized from the 2'-anthracene-modified uridine. The modified oligonucleotides bind to both the complementary DNA and RNA segments. The induced CD at around 375 nm due to the anthracene chromophore was seen only for the anthracene-modified duplexes with DNA but not for those with RNA, which is in good agreement with the modification-induced stability of the duplexes. The oligonucleotide with anthracene at the specified sugar residue exhibits enhanced fluorescence upon binding to the complementary RNA segment.

  DOI：

  10.1016/0040-4039(95)01707-o
• 作为产物：
  描述：

  蒽醌-2-羧酸 在 氢氧化钾 、 lithium aluminium tetrahydride 、 氯化亚砜 、 sodium dithionite 、 铜 、 溶剂黄146 、 锌 作用下， 以 1,4-二氧六环 、 苯 为溶剂， 生成 1-[(2R,3R,4R,5R)-3-(anthracen-2-ylmethoxy)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
  参考文献：
  名称：

  Oligonucleotides having covalently linked anthracene at specific sugar residue: Differential binding to DNA and RNA and fluorescence properties

  摘要：

  Oligonucleotide 15 -mers containing 2-anthracenylmethyl groups at specific sugar residues have been synthesized from the 2'-anthracene-modified uridine. The modified oligonucleotides bind to both the complementary DNA and RNA segments. The induced CD at around 375 nm due to the anthracene chromophore was seen only for the anthracene-modified duplexes with DNA but not for those with RNA, which is in good agreement with the modification-induced stability of the duplexes. The oligonucleotide with anthracene at the specified sugar residue exhibits enhanced fluorescence upon binding to the complementary RNA segment.

  DOI：

  10.1016/0040-4039(95)01707-o