methyl (2E,4E)-2,6-dimethylhepta-2,4-dienoate | 145440-79-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl (2E,4E)-2,6-dimethylhepta-2,4-dienoate
• CAS: 145440-79-5
• 化学式: C₁₀H₁₆O₂
• 分子量: 168.236
• InChiKey: USXLODRCBKKTSH-SBIWHPGTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Bis(2,2,2-trifluoroethyl) 3-(methoxycarbonyl)-3-methylprop-2-enylphosphonate 、 异丁醛 在 正丁基锂 作用下， 以 乙醚 为溶剂， 生成 methyl (2E,4Z)-2,6-dimethylhepta-2,4-dienoate 、 methyl (2E,4E)-2,6-dimethylhepta-2,4-dienoate
  参考文献：
  名称：

  Asymmetric synthesis of macbecin I

  摘要：

  The asymmetric synthesis of macbecin I is described wherein the absolute stereochemical relationships were established through the use of chiral boron aldol bond constructions and internally directed alpha-methoxy ketone reduction, while the E,Z dienic amide moiety was installed in one step using a vinylogous phosphonate reagent.

  DOI：

  10.1021/jo00030a006

文献信息

• Asymmetric synthesis of macbecin I
  作者：David A. Evans、Scott J. Miller、Michael D. Ennis、Paul L. Ornstein

  DOI：10.1021/jo00030a006

  日期：1992.2

  The asymmetric synthesis of macbecin I is described wherein the absolute stereochemical relationships were established through the use of chiral boron aldol bond constructions and internally directed alpha-methoxy ketone reduction, while the E,Z dienic amide moiety was installed in one step using a vinylogous phosphonate reagent.