acetic acid-(2,3,4,5-tetrahydro-oxepin-2-yl ester) | 95528-48-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: acetic acid-(2,3,4,5-tetrahydro-oxepin-2-yl ester)
• 英文别名: Essigsaeure-(2,3,4,5-tetrahydro-oxepin-2-ylester)；2,3,4,5-tetrahydrooxepin-2-yl Acetate
• CAS: 95528-48-6
• 化学式: C₈H₁₂O₃
• 分子量: 156.181
• InChiKey: GZCBDJXMTJDJAN-UHFFFAOYSA-N

物化性质

• 沸点：
  216.0±40.0 °C(Predicted)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  acetic acid-(2,3,4,5-tetrahydro-oxepin-2-yl ester) 在 sodium hydroxide 、 盐酸羟胺 作用下， 生成 hexanedial dioxime
  参考文献：
  名称：

  The Oxidation of Hydrocarbons. I. The Oxidation of Cyclohexene in Acetic and Propionic Anhydride Solutions¹

  摘要：

  DOI：

  10.1021/ja01545a040
• 作为产物：
  描述：

  peroxyacetic acid cyclohex-2-enyl ester 在 三氟化硼乙醚 作用下， 反应 0.5h， 生成 acetic acid-(2,3,4,5-tetrahydro-oxepin-2-yl ester) 、 4,5-dihydro-oxepin
  参考文献：
  名称：

  Extension of the Criegee Rearrangement: Synthesis of Enol Ethers from Secondary Allylic Hydroperoxides

  摘要：

  The Criegee rearrangement has been extended to secondary allylic hydroperoxides, allowing for the selective synthesis of cyclic and acyclic enol ethers; the effect of base and electrophilic agent was studied.

  DOI：

  10.1021/jo00097a006

文献信息

• POLYMER PARTICLES OR NANO-VECTORS AND USE THEREOF AS A DRUG AND/OR DIAGNOSTIC AGENT
  申请人：Bertrand Philippe

  公开号：US20140219925A1

  公开（公告）日：2014-08-07

  Novel polymer nanovectors or particles and use thereof as medication and/or diagnostic agents.

  新型聚合物纳米载体或颗粒及其作为药物和/或诊断试剂的用途。
• Stimulateable Polymer Particles Exhibiting Reactive Functions, Method for the Production and the Use Thereof
  申请人：Sabaut-Heroguez Valerie

  公开号：US20090123555A1

  公开（公告）日：2009-05-14

  The invention relates to spherical particles formed by polymer chains containing approximately from 30 to 10000 monomer units derived from monocyclic polycyclic alkene polymerization, wherein at least one monomer unit is substituted by an R chain including ethylene polyoxide which is optionally covalently linked to the polymer units through a hydrolyzable bridge and substituted by a reactive function, optionally engaged in a link with an active principle or a biological molecule such as protein, wherein the chain R is covalently linked to the monomer units. The use of the inventive spherical particles for preparing pharmaceutical and cosmetic compositions or surface coatings is also disclosed.

  该发明涉及由聚合物链形成的球形颗粒，其中该聚合物链含有大约30至10000个单体单位，这些单体单位来自单环多环烯烃聚合物化，其中至少一个单体单位被R链取代，该R链包括乙烯聚氧化物，该乙烯聚氧化物可以通过可水解的桥连接到聚合物单元，并且被反应性功能取代，可选择地与活性原理或生物分子（如蛋白质）结合，其中链R与单体单位以共价键连接。该创新球形颗粒用于制备制药和化妆品配方或表面涂层。
• POLYMER PARTICLES AND BIOMATERIALS COMPRISING THE SAME
  申请人：UNIVERSITE DE BORDEAUX

  公开号：US20170360947A1

  公开（公告）日：2017-12-21

  The present invention relates to polymer particles comprising antibiotics which are deliverable in situ, as well as a method of preparation thereof. The present invention also relates to bioactive biomaterials for the controlled delivery of antibiotics comprising support materials having such polymer particles on their surface. The invention also relates to implants, prostheses, stents, lenses or cements as well as any pharmaceutical composition comprising said biomaterials.

  本发明涉及聚合物颗粒，其中包含可以在现场释放的抗生素，以及其制备方法。本发明还涉及用于控制性释放抗生素的生物活性生物材料，其中包括具有这种聚合物颗粒的支撑材料表面。本发明还涉及植入物、假体、支架、镜片或水泥，以及任何包含所述生物材料的制药组合物。
• Polymer particles and biomaterials comprising the same
  申请人：UNIVERSITE DE BORDEAUX

  公开号：EP3034538A1

  公开（公告）日：2016-06-22

  The present invention relates to polymer particles comprising antibiotics which are deliverable in situ, as well as a method of preparation thereof. The present invention also relates to bioactive biomaterials for the controlled delivery of antibiotics comprising support materials having such polymer particles on their surface. The invention also relates to implants, prostheses, stents, lenses or cements as well as any pharmaceutical composition comprising said biomaterials.

  本发明涉及含有可就地递送抗生素的聚合物颗粒及其制备方法。本发明还涉及用于控制抗生素递送的生物活性生物材料，包括表面具有此类聚合物颗粒的支撑材料。本发明还涉及植入物、假体、支架、镜片或水泥以及任何包含上述生物材料的药物组合物。
• Goodman Richard M., Kishi Yoshito, J. Org. Chem., 18 (1994) N 59, S 5125-5127
  作者：Goodman Richard M., Kishi Yoshito

  DOI：——

  日期：——