[Cu(L-LysO)2] | 39691-88-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [Cu(L-LysO)2]
• 英文别名: L-lysine ; copper (II)-salt；L-Lysin; Kupfer(II)-Salz
• CAS: 39691-88-8
• 化学式: 2C₆H₁₃N₂O₂*Cu
• 分子量: 353.909
• InChiKey: ZVISADMYNPWUHR-JEDNCBNOSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.81
• 重原子数：
  11.0
• 可旋转键数：
  5.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  92.17
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  [Cu(L-LysO)2] 在 钯 氢气 作用下， 以 叔丁醇 为溶剂， 生成 EPSILON-(GAMMA-L-谷氨酰)-L-赖氨酸
  参考文献：
  名称：

  Zahn,H.; Paetzold,W., Chemische Berichte, 1963, vol. 96, p. 2566 - 2576

  摘要：

  DOI：
• 作为产物：
  描述：

  L-赖氨酸 、 copper(II) nitrate 以 水 为溶剂， 生成 [Cu(L-LysO)H]2+ 、 [Cu(L-LysO)H]2+ 、 [Cu(L-LysO)2H]+ 、 [Cu(L-LysO)2]
  参考文献：
  名称：

  Copper(II) complexes with l-lysine and l-ornithine: is the side-chain involved in the coordination?

  摘要：

  The involvement of the omega -NH2 terminal group of L-lysine and L-ornithine in the complexation of Cu(II) was investigated by means of potentiometry, calorimetry, UV-Vis and ESR. The thermodynamic parameters (DeltaG(0), DeltaH(0) and DeltaS(0)) obtained by combining the potentiometric and calorimetric data show that the two ligands complex copper(II) in a different manner, indicating that the omega -NH2 terminal group is involved in ornithine complexes only. UV-Vis and ESR spectra further support the involvement of ornithine omega -NH2 and provide details on the complexation geometries of the complexes of the two amino acids. (C) 2000 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0040-6031(00)00633-x

文献信息

• A fluoride ion deprotection strategy in peptide synthesis. Combination with selective deprotection using the dilute methanesulfonic acid of .ALPHA.-amino protecting groups.
  作者：Yoshiaki Kiso、Tooru Kimura、Yoichi Fujiwara、Masanori Shimokura、Akiko Nishitani

  DOI：10.1248/cpb.36.5024

  日期：——

  We have developed a novel orthogonal protection methodology in peptide synthesis which involves two classes of acid-labile‘temporary’Nα-protecting groups and acidstable but fluoride ion-labile‘permanent’protecting groups. This fluoride ion final deprotection strategy was successfully applied to the synthesis of bradykinin potentiating peptide 5a in combination with selective deprotection using dilute methanesulfonic acid of the Nα-t-butoxycarbonyl group on the acid-stable phenacyl ester linkage-resin cleavable with fluoride ion. The more acid-labile Nα-p-methoxybenzyloxycarbonyl group on the p-(carbamoylmethyl)-benzyl ester linkage-resin was also used.

  我们开发了一种在肽合成中新型的正交保护方法，包括两类酸敏感的“临时”Nα-保护基团和酸稳定但对氟离子敏感的“永久”保护基团。这个氟离子最终去保护策略成功应用于布拉迪激肽增强肽5a的合成，结合使用稀甲烷磺酸选择性去保护酸稳定的苯乙酰酯连接体上的Nα-t-丁氧羰基基团，该连接体可被氟离子裂解。同时，酸敏感的Nα-p-甲氧基苄氧羰基基团也被应用于p-(氨基甲基)-苯甲酯连接体上的树脂。
• Solid phase synthesis of liquid crystalline oligopeptides
  作者：Peter A. G. Cormack、Barry D. Moore、David C. Sherrington

  DOI：10.1039/cc9960000353

  日期：——

  Structurally well-defined liquid crystalline oligopeptides based upon a side-chain -mesogenically substituted L-lysine residue are prepared via solid phase peptide synthesis (SPPS).

  通过固相肽合成（SPPS）制备基于侧链介晶取代的L-赖氨酸残基的结构明确的液晶寡肽。
• SYNTHESIS OF SOME PEPTIDES OF ε-N-ACETYL-<scp>L</scp>-LYSINE
  作者：Leo Benoiton

  DOI：10.1139/v63-246

  日期：1963.7.1

  ε-N-Acetyl-L-lysinamide, α-N-glycyl-ε-N-acetyl-L-lysine, ε-N-acetyl-L-lysylglycine, α-N-glycyl-ε-N-acetyl-L-lysylglycine, and ε-N-acetylglycyl-L-lysine have been synthesized for testing as substrates for the enzyme ε-lysine acylase.

  ε-N-乙酰-L-赖氨酰胺，α-N-甘氨酰-ε-N-乙酰-L-赖氨酸，ε-N-乙酰-L-赖氨酰甘氨酸，α-N-甘氨酰-ε-N-乙酰-L-赖氨酰甘氨酸和ε-N-乙酰甘氨酰-L-赖氨酸已经被合成，用于测试作为ε-赖氨酸酰化酶的底物。
• N.omega.-Alkoxycarbonylation of .alpha.,.omega.-diamino acids with 2-(trimethylsilyl)ethyl 4-nitrophenyl carbonate
  作者：Andre Rosowsky、Joel E. Wright

  DOI：10.1021/jo00157a034

  日期：1983.5
• Copper(II) complexes with l-lysine and l-ornithine: is the side-chain involved in the coordination?
  作者：Chiara Conato、Annalinda Contino、Giuseppe Maccarrone、Antonio Magrı̀、Maurizio Remelli、Giovanni Tabbı̀

  DOI：10.1016/s0040-6031(00)00633-x

  日期：2000.11

  The involvement of the omega -NH2 terminal group of L-lysine and L-ornithine in the complexation of Cu(II) was investigated by means of potentiometry, calorimetry, UV-Vis and ESR. The thermodynamic parameters (DeltaG(0), DeltaH(0) and DeltaS(0)) obtained by combining the potentiometric and calorimetric data show that the two ligands complex copper(II) in a different manner, indicating that the omega -NH2 terminal group is involved in ornithine complexes only. UV-Vis and ESR spectra further support the involvement of ornithine omega -NH2 and provide details on the complexation geometries of the complexes of the two amino acids. (C) 2000 Elsevier Science B.V. All rights reserved.