N-[(β-D-galactopyranosyl)-(1->4)-(β-D-glucopyranosyloxy-carbonyl)]glycyldioctadecylamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[(β-D-galactopyranosyl)-(1->4)-(β-D-glucopyranosyloxy-carbonyl)]glycyldioctadecylamide
• 英文别名: [(2S,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl] N-[2-(dioctadecylamino)-2-oxoethyl]carbamate
• 化学式: C₅₁H₉₈N₂O₁₃
• 分子量: 947.345
• InChiKey: QKBGISUUVJOMHH-NUGLBZMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.9
• 重原子数：
  66
• 可旋转键数：
  42
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  228
• 氢给体数：
  8
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  2,3,6,2',3',4',6'-hepta-O-acetyl-lactose 在 吡啶 、 sodium methylate 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 10.0h， 生成 N-[(β-D-galactopyranosyl)-(1->4)-(β-D-glucopyranosyloxy-carbonyl)]glycyldioctadecylamide
  参考文献：
  名称：

  SYNTHESIS OF NEW GALACTOSYL AND LACTOSYL CARBAMATE-CONTAINING GLYCOLIPIDS

  摘要：

  An efficient synthesis of mono-, di- and tetrasaccharides linked to a lipid has been developed. Galactose or lactose was covalently coupled to a glycyldioctadecylamide, via well-defined chemical steps, in both an alpha and beta anomeric configuration. The multiantennary galactosyl ligands were obtained using 1,3-diamino-2-propanol as a scaffold.

  DOI：

  10.1081/car-100108661

文献信息

• SYNTHESIS OF NEW GALACTOSYL AND LACTOSYL CARBAMATE-CONTAINING GLYCOLIPIDS
  作者：Michel Azoulay、Virginie Escriou、Jean-Claude Florent、Claude Monneret

  DOI：10.1081/car-100108661

  日期：2001.12.31

  An efficient synthesis of mono-, di- and tetrasaccharides linked to a lipid has been developed. Galactose or lactose was covalently coupled to a glycyldioctadecylamide, via well-defined chemical steps, in both an alpha and beta anomeric configuration. The multiantennary galactosyl ligands were obtained using 1,3-diamino-2-propanol as a scaffold.