2-hydroxy-5-iodo-N-phenylbenzamide | 2441-58-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-5-iodo-N-phenylbenzamide
• CAS: 2441-58-9
• 化学式: C₁₃H₁₀INO₂
• 分子量: 339.132
• InChiKey: OGEXIPVUPBXZGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-hydroxy-5-iodo-N-phenylbenzamide 在 sodium tetrahydroborate 、 palladium diacetate 、 magnesium sulfate 、 potassium hydroxide 作用下， 以 四氢呋喃 、 水 、 丙酮 为溶剂， 生成
  参考文献：
  名称：

  一系列新型水杨酰苯胺作为EGFR蛋白酪氨酸激酶抑制剂的合成及生物学评价

  摘要：

  摘要进行了两个水杨酰苯胺衍生物对EGFR和ErbB-2酪氨酸激酶抑制活性的合成和生物学评价。在测试的化合物中，苯胺环上具有一个额外的芳基取代基的化合物对EGFR酪氨酸激酶抑制具有活性（7a – c和13a，13c，13d，13f）。抑制活性都在低微摩尔或亚微摩尔范围内。另外，发现化合物13a对EGFR和ErbB-2酪氨酸激酶均具有双重抑制活性（1.654±1.280和7.134±1.265μmol/ L）。

  DOI：

  10.1016/j.cclet.2012.03.016
• 作为产物：
  描述：

  5-碘水杨酸 在 草酰氯 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 2-hydroxy-5-iodo-N-phenylbenzamide
  参考文献：
  名称：

  Design, Synthesis, and Biological Activities of Closantel Analogues: Structural Promiscuity and Its Impact on Onchocerca volvulus

  摘要：

  Onchocerciasis, or river blindness, is a neglected tropical disease that affects more than 37 million people worldwide, primarily in Africa and Central and South America. We have disclosed evidence that the larval-stage-specific chitinase, OvCHT1, may be a potential biological target for affecting nematode development. On the basis of screening efforts, closantel, a known anthelmintic drug, was discovered as a potent and highly specific OvCHT1 inhibitor. Originally, closantel's anthelmintic mode of action was believed to rely solely on its role as a proton ionophore; thus, the impact of each of its biological activities on O. volvulus L3 molting was investigated. Structure activity relationship studies on an active closantel fragment are detailed, and remarkably, by use of a simple salicylanilide scaffold, compounds acting only as protonophores or chitinase inhibitors were identified. From these data, unexpected synergistic protonophore and chitinase inhibition activities have also been found to be critical for molting in O. volvulus L3 larvae.

  DOI：

  10.1021/jm200364n

文献信息

• Biocide compositions and methods and systems employing same
  申请人：——

  公开号：US20020014178A1

  公开（公告）日：2002-02-07

  The present invention relates to biocides, more particularly salicylanilide compositions, preferably substituted salicylanilide compositions, useful in biocide compositions, bacteria-reducing systems, biocide products and bacteria-reducing methods.

  本发明涉及杀菌剂，尤其是水杨酰苯胺组合物，最好是取代的水杨酰苯胺组合物，可用于杀菌剂组合物、细菌减少系统、杀菌剂产品和细菌减少方法。
• Antibacterial agents and compositions, methods and systems employing same
  申请人：——

  公开号：US20020068014A1

  公开（公告）日：2002-06-06

  The present invention relates to antibacterial agents, more particularly salicylanilide substituted compositions, preferably monosubstituted salicylanilide compositions, most preferably monohalogenated salicylanilide compositions, useful in antibacterial compositions, bacteria-reducing systems, antibacterial products and bacteria-reducing methods.

  本发明涉及抗菌剂，尤其是水杨酰苯胺取代的组合物，最好是单取代水杨酰苯胺组合物，最优选的是单卤代水杨酰苯胺组合物，可用于抗菌组合物、细菌减少系统、抗菌产品和细菌减少方法。
• BIOCIDE COMPOSITIONS AND METHODS AND SYSTEMS EMPLOYING SAME
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP1349453A2

  公开（公告）日：2003-10-08
• [EN] BIOCIDE COMPOSITIONS AND METHODS AND SYSTEMS EMPLOYING SAME<br/>[FR] COMPOSITIONS DE BIOCIDES, ET PROCEDES ET SYSTEMES UTILISANT CES COMPOSITIONS
  申请人：PROCTER & GAMBLE

  公开号：WO2002005643A2

  公开（公告）日：2002-01-24

  The present invention relates to biocides, more particularly salicylanilide compositions, preferably substituted salicylanilide compositions, useful in biocide compositions, bacteria-reducing systems, biocide products and bacteria-reducing methods.