6-(1,1′-biphenyl-4-yloxy)hexan-1-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-(1,1′-biphenyl-4-yloxy)hexan-1-ol
• 英文别名: 6-[(4-phenyl)-phenoxy]-1-hexanol；6-(4-phenylphenoxy)hexan-1-ol
• 化学式: C₁₈H₂₂O₂
• 分子量: 270.371
• InChiKey: JEEKYDUFGJQLHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(1,1′-biphenyl-4-yloxy)hexan-1-ol 在 草酰氯 、 二甲基亚砜 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 2-[2-hydroxy-7-(4-phenyl)phenoxyheptyl]-6-methoxy-3,5-dimethyl-4H-pyran-4-one
  参考文献：
  名称：

  Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors

  摘要：

  Verticipyrone has recently been isolated from the culture broth of Verticillium sp. and shown to inhibit NADH fumarate reductase, as well as NADH oxidoreductase ( complex I) of the mitochondrial electron transport chain. In order to assess the structural elements in verticipyrone essential for complex I inhibitor, 15 structural analogues were prepared and analyzed for their effects on mitochondrial NADH oxidoreductase and NADH oxidase activities. Also measured were the abilities of several of the analogues to inhibit respiration as judged by a shift to glycolysis, and to inhibit the growth of several mammalian cell lines. The nature of the pyrone ring was shown to be important to potency of inhibition, as was the length and nature of substituents in the side chain of the analogues. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.03.070
• 作为产物：
  描述：

  6-溴正己醇 、 对羟基联苯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以57%的产率得到6-(1,1′-biphenyl-4-yloxy)hexan-1-ol
  参考文献：
  名称：

  Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors

  摘要：

  Verticipyrone has recently been isolated from the culture broth of Verticillium sp. and shown to inhibit NADH fumarate reductase, as well as NADH oxidoreductase ( complex I) of the mitochondrial electron transport chain. In order to assess the structural elements in verticipyrone essential for complex I inhibitor, 15 structural analogues were prepared and analyzed for their effects on mitochondrial NADH oxidoreductase and NADH oxidase activities. Also measured were the abilities of several of the analogues to inhibit respiration as judged by a shift to glycolysis, and to inhibit the growth of several mammalian cell lines. The nature of the pyrone ring was shown to be important to potency of inhibition, as was the length and nature of substituents in the side chain of the analogues. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.03.070

文献信息

• Dynamic Anti-Icing Coatings: Complex, Amphiphilic Hyperbranched Fluoropolymer Poly(ethylene glycol) Cross-Linked Networks with an Integrated Liquid Crystalline Comonomer
  作者：Jennifer S. Zigmond、Adriana Pavía-Sanders、Joel D. Russell、Karen L. Wooley

  DOI：10.1021/acs.chemmater.6b02013

  日期：2016.8.9

  Amphiphilic hyperbranched fluoropolymer coatings incorporating liquid crystalline moieties and poly(ethylene glycol) cross-linkers were found to demonstrate noteworthy anti-icing properties. A series of amphiphilic networks was synthesized through variation of the polymer molecular weights and hydrophilic/hydrophobic component ratios. These innovative materials show a remarkable reduction in the free

  发现结合了液晶部分和聚（乙二醇）交联剂的两亲性超支化含氟聚合物涂料显示出值得注意的防冰性能。通过改变聚合物的分子量和亲水/疏水组分的比例合成了一系列两亲网络。这些创新的材料显示出通过差示扫描量热法测得的自由水熔融转变（T m）温度（-10°C）显着降低，并且对于干燥和水溶胀的系统，水接触角增加。该有序参数的添加产生了独特的涂层形貌，可以通过偏振光学显微镜和3D光学显微镜将其可视化，同时保持整体的宏观均匀性。
• Waveplate and optical devices formed using mesogen-containing polymer
  申请人：Purchase Ken

  公开号：US20050100265A1

  公开（公告）日：2005-05-12

  Waveplate, planar lightwave circuit incorporating the waveplate, and method of making an optical device. The waveplate is formed of a mesogen-containing polymer film having a backbone and sidechains containing mesogen groups. The waveplate may be formed by producing a mesogen-containing polymer film having a nonzero birefringence of suitable dimensions for insertion into a planar lightwave circuit. The waveplate may be so inserted into an optical circuit of a planar lightwave circuit so that an optical signal traversing the waveplate is changed, for instance, to have two polarization states.

  波片、结合波片的平面光波电路以及制造光学器件的方法。该波片由含有基干和侧链的介质基团的聚合物薄膜形成。可以通过制备具有适当尺寸的非零双折射率的介质基团聚合物薄膜来形成波片，并将其插入平面光波电路的光学电路中，使通过波片的光信号发生变化，例如具有两种极化状态。
• Aryloxy alkanols as anti-retrovirus agents
  申请人：Merrell Dow Pharmaceuticals Inc.

  公开号：US05177108A1

  公开（公告）日：1993-01-05

  Aryloxyalkanol derivatives having the formula Ar--O(CH.sub.2).sub.n OH wherein n is an integer from 3 to 8 and Ar is (1) 1- or 2-naphthylenyl, (2) phenyl optionally substituted by from 1 to 3 C.sub.1-4 lower alkyl groups, or (3) a diphenyl moiety of structure ##STR1## wherein Y is a bond, CH.sub.2 or CH.sub.2 O, and esters thereof have antiretrovirus activity and are effective in a method for treatment of a retrovirus infection.

  具有以下公式的Aryloxyalkanol衍生物：Ar--O(CH.sub.2).sub.n OH，其中n为3到8的整数，Ar为（1）1-或2-萘基，（2）苯基，可选地被1至3个C.sub.1-4低烷基取代，或（3）结构为##STR1##的二苯基基团，其中Y为键，CH.sub.2或CH.sub.2 O，以及其酯具有抗逆转录病毒活性，并且在逆转录病毒感染的治疗方法中有效。
• Waveplate and optical circuit formed from mesogen-containing polymer
  申请人：——

  公开号：US20040013337A1

  公开（公告）日：2004-01-22

  Waveplates formed of mesogen-containing polymers and planar lightwave circuits containing such waveplates. Polymers have sidechains containing mesogens such as biphenyl-containing groups. Polymers may have a glass transition temperature between 100 C. and 300 C., and polymers may be stretched in excess of 150% to increase birefringence of polymer and provide thin films. Waveplates formed of stretched polymer films may have high biaxial birefringence.

  由含有介质基团的聚合物形成的波片和包含这种波片的平面光波电路。该聚合物具有含有二苯基基团等介质的侧链。聚合物的玻璃转移温度可能在100°C到300°C之间，并且聚合物可拉伸超过150％，以增加聚合物的双折射并提供薄膜。由拉伸聚合物薄膜形成的波片可能具有高双轴双折射率。
• Polymerizable liquid crystal composition and optically anisotropic medium
  申请人：Kawamura Jyoji

  公开号：US20070170394A1

  公开（公告）日：2007-07-26

  A polymerizable liquid crystal composition includes a liquid crystal compound having a polymerizable group, wherein the composition includes from 0.1 to 6.0% by weight of a (meth)acrylic copolymer (H), which 1) has a side chain containing a fluorine group, and a side chain containing a group represented by a general formula (h): 2) has a fluorine group content of 3 to 30% by weight, 3) has a ratio of side chains containing the group represented by the general formula (h) relative to the combined total of all side chains that falls within a range from 9 to 95 mol %, and 4) has a weight average molecular weight within a range from 10,000 to 300,000.

  一种可聚合液晶组合物，包括具有聚合基团的液晶化合物，其中该组合物包括0.1至6.0重量％的（甲基）丙烯酸共聚物（H），该共聚物：1）具有含有氟基的侧链和含有通式（h）所代表的基团的侧链；2）具有3至30重量％的氟含量；3）具有含有通式（h）所代表的基团的侧链与所有侧链的总和的比率在9至95摩尔％的范围内；4）具有10,000至300,000范围内的重均分子量。