12-(2-Oxo-2λ5-[1,3,2]dioxaphospholan-2-yloxy)-dodecanoic acid 4-vinyl-benzyl ester | 1313606-85-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 12-(2-Oxo-2λ5-[1,3,2]dioxaphospholan-2-yloxy)-dodecanoic acid 4-vinyl-benzyl ester
• 英文别名: 12-(2-Oxo-2λ5-[1,3,2]dioxaphospholan-2-yloxy)-dodecanoic acid 4-vinyl-benzyl ester；(4-Ethenylphenyl)methyl 12-[(2-oxo-1,3,2lambda5-dioxaphospholan-2-yl)oxy]dodecanoate；(4-ethenylphenyl)methyl 12-[(2-oxo-1,3,2λ5-dioxaphospholan-2-yl)oxy]dodecanoate
• CAS: 1313606-85-7
• 化学式: C₂₃H₃₅O₆P
• 分子量: 438.501
• InChiKey: VAFONEFCHCMPQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  30
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  12-(2-Oxo-2λ5-[1,3,2]dioxaphospholan-2-yloxy)-dodecanoic acid 4-vinyl-benzyl ester 、 三甲胺 以 乙腈 为溶剂， 反应 24.0h， 以25%的产率得到
  参考文献：
  名称：

  C-Reactive protein-directed immobilization of phosphocholine ligands on a solid surface

  摘要：

  在苯乙烯-水界面吸附的C-反应蛋白（CRP）与其可聚合的磷酸胆碱配体的复合物被聚合。所得分子印迹聚合物（MIP）对CRP的结合亲和力与固定化的抗CRP抗体相当。基于MIP的夹心免疫分析法已被用于人血清中CRP的测定。

  DOI：

  10.1039/c1cc15079k
• 作为产物：
  描述：

  4-氯甲基苯乙烯 在 potassium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 生成 12-(2-Oxo-2λ5-[1,3,2]dioxaphospholan-2-yloxy)-dodecanoic acid 4-vinyl-benzyl ester
  参考文献：
  名称：

  C-Reactive protein-directed immobilization of phosphocholine ligands on a solid surface

  摘要：

  在苯乙烯-水界面吸附的C-反应蛋白（CRP）与其可聚合的磷酸胆碱配体的复合物被聚合。所得分子印迹聚合物（MIP）对CRP的结合亲和力与固定化的抗CRP抗体相当。基于MIP的夹心免疫分析法已被用于人血清中CRP的测定。

  DOI：

  10.1039/c1cc15079k

文献信息

• MOLECULARLY PRINTED POLYMER FOR DETECTING THE PENTRAXIN, AND METHOD FOR PREPARING SAME
  申请人：Jeong Sang Won

  公开号：US20120128536A1

  公开（公告）日：2012-05-24

  The present disclosure relates to a molecularly imprinted structure for detection of a pentraxin protein and a method for preparing the same by synthesizing a reactive group-pentraxin protein ligand complex specifically reacting with the pentraxin protein and being polymerizable with a crosslink agent to detect a pentraxin protein by using the complex. The present disclosure also provides a chip for detection of a C-reactive protein and a method for preparing the same, the chip including a molecularly imprinted layer having excellent sensitivity to a C-reactive protein and an improved binding force to a metal substrate by using click chemistry.

  本公开涉及一种分子印迹结构，用于检测Pentraxin蛋白质，并通过合成与Pentraxin蛋白质特异性反应且可与交联剂聚合的反应基-Pentraxin蛋白质配体复合物来制备该结构的方法，以使用该复合物检测Pentraxin蛋白质。本公开还提供了一种C-反应蛋白检测芯片及其制备方法，该芯片包括具有对C-反应蛋白质具有良好灵敏度且使用点击化学法改善对金属基板的结合力的分子印迹层。
• MOLECULARLY IMPRINTED POLYMER FOR DETECTION OF PENTRAXIN PROTEIN AND METHOD FOR PREPARING THE SAME
  申请人：Daegu Gyeongbuk Institute of Science and Technology

  公开号：US20150241449A1

  公开（公告）日：2015-08-27

  The present disclosure relates to a molecularly imprinted structure for detection of a pentraxin protein and a method for preparing the same by synthesizing a reactive group-pentraxin protein ligand complex specifically reacting with the pentraxin protein and being polymerizable with a crosslink agent to detect a pentraxin protein by using the complex. The present disclosure also provides a chip for detection of a C-reactive protein and a method for preparing the same, the chip including a molecularly imprinted layer having excellent sensitivity to a C-reactive protein and an improved binding force to a metal substrate by using click chemistry.
• US9034258B2
  申请人：——

  公开号：US9034258B2

  公开（公告）日：2015-05-19
• US9664691B2
  申请人：——

  公开号：US9664691B2

  公开（公告）日：2017-05-30
• [EN] MOLECULARLY PRINTED POLYMER FOR DETECTING THE PENTRAXIN PROTEIN, AND METHOD FOR PREPARING SAME<br/>[FR] POLYMÈRE À EMPREINTE MOLÉCULAIRE POUR LA DÉTECTION DE LA PROTÉINE PENTRAXINE, ET SON PROCÉDÉ DE PRÉPARATION
  申请人：DAEGU GYEONGBUK INST SCIENCE

  公开号：WO2011081272A1

  公开（公告）日：2011-07-07

  본 발명은 펜트락신 단백질 검출용 분자각인체 및 그 제조방법에 관한 것으로, 더욱 구체적으로 반응기(R)와 펜트락신 단백질 리간드(L)가 결합된 반응기-펜트락신 단백질 리간드(L-S-R)를 제조하고, 이를 펜트락신 단백질과 반응시킨 후 가교제 및 개시제를 혼합하고 광중합 또는 열중합 반응시켜 펜트락신 단백질로 분자각인된 리간드가 결합된 중합체를 제조하는 것을 포함하는 펜트락신 단백질 검출용 분자각인 고분자의 제조방법에 관한 것이다. 본 발명에 따르면, 펜트락신 단백질 리간드(L)를 직접 반응성 표면에 중합할 수 있도록 디자인된 반응기-펜트락신 단백질 리간드(L-S-R)를 분자각인된 형태로 반응성 표면에서 화학반응시킴으로써, 펜트락신 단백질이 보다 특이적으로 반응할 수 있는 분자각인체를 제조할 수 있다. 본 발명의 반응기-펜트락신 단백질 리간드(L-S-R)를 이용하여 다양한 형태의 중합반응 또는 화학반응에 적용할 수 있으며, 단일 펜트락신 단백질 리간드 보다 강한 결합력을 갖도록 배열된 분자각인 펜트락신 단백질 리간드를 이용하여 펜트락신 단백질의 검출을 보다 용이하게 할 수 있다.