methyl 4-methyl-3-oxohexanoate | 90113-54-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: methyl 4-methyl-3-oxohexanoate
• CAS: 90113-54-5
• 化学式: C₈H₁₄O₃
• 分子量: 158.197
• InChiKey: XAXXMCKRKUYHNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 4-methyl-3-oxohexanoate 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 28.0h， 生成
  参考文献：
  名称：

  Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes

  摘要：

  GPR142 is a G protein-coupled receptor that is predominantly expressed in pancreatic beta-cells. GPR142 agonists stimulate insulin secretion in the presence of high glucose concentration, so that they could be novel insulin secretagogues with reduced or no risk of hypoglycemia. We report here the optimization of HTS hit compound 1 toward a proof of concept compound 33, which showed potent glucose lowering effects during an oral glucose tolerance test in mice and monkeys.

  DOI：

  10.1021/ml400186z
• 作为产物：
  描述：

  2-甲基丁酰氯 在 吡啶 作用下， 以 氯仿 为溶剂， 反应 3.0h， 生成 methyl 4-methyl-3-oxohexanoate
  参考文献：
  名称：

  A new approach to the synthesis of 3,6- and 5,6-dialkyl derivatives of 4-hydroxy-2-pyrone. Synthesis of rac-germicidin

  摘要：

  A new approach to the synthesis of 3,6- and 5,6-dialkyl-4-hydroxy-2-pyrones has been developed. The method includes the formation of acylated Meldrum's acids (5-(2-alkyl-3-oxoacyl)-2,2-dimethyl-1,3-dioxane-4,6-diones) followed by their thermal transformation. Introduction of 3-alkyl substituents was accomplished by acylation of 4-hydroxy-2-pyrones and ionic hydrogenation of the 3-acyl derivatives obtained. The effectiveness of this new approach has been demonstrated in the synthesis of rac-germicidin, an autoregulative germination inhibitor of Streptomyces viridochromogenes NRRL B-1551. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00150-7

文献信息

• WO2020113209A5
  申请人：——

  公开号：WO2020113209A5

  公开（公告）日：2022-12-08
• METHODS AND COMPOSITIONS FOR CONSUMABLES
  申请人：Impossible Foods Inc.

  公开号：EP2943078A1

  公开（公告）日：2015-11-18
• PANTETHEINE DERIVATIVES AND USES THEREOF
  申请人：Comet Therapeutics, Inc.

  公开号：EP3887353A1

  公开（公告）日：2021-10-06
• [EN] METHODS AND COMPOSITIONS FOR CONSUMABLES<br/>[FR] PROCÉDÉS ET COMPOSITIONS UTILISABLES EN VUE DE LA PRODUCTION DE PRODUITS COMESTIBLES
  申请人：MARAXI INC

  公开号：WO2014110539A1

  公开（公告）日：2014-07-17

  Methods and compositions for the production of non-meat consumable products are described herein. A meat substitute is described which is constructed from a muscle analog, a fat analog, and a connective tissue analog.
• [EN] PANTETHEINE DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE PANTÉTHÉINE ET LEURS UTILISATIONS
  申请人：COMET THERAPEUTICS INC

  公开号：WO2020113209A1

  公开（公告）日：2020-06-04

  The present disclosure relates to compounds of Formula (I), (II), or (II'): (I), (II), (II'), and pharmaceutically acceptable salts or solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the compounds and therapeutic and diagnostic uses of the compounds and pharmaceutical compositions.