Z-Ala-Phe-OEt | 2953-41-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-Ala-Phe-OEt
• 英文别名: carbobenzoxy-L-alanyl-L-phenylalanine ethyl ester；ethyl (2S)-3-phenyl-2-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoate
• CAS: 2953-41-5
• 化学式: C₂₂H₂₆N₂O₅
• 分子量: 398.459
• InChiKey: QQHNZZAZZVXEJM-LPHOPBHVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  93.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Z-Ala-Phe-OEt 在 sodium hydroxide 作用下， 生成 苄氧羰基-L-丙氨酰-L-苯丙氨酸
  参考文献：
  名称：

  Bergmann; Fruton, Journal of Biological Chemistry, 1942, vol. 145, p. 247,251

  摘要：

  DOI：
• 作为产物：
  描述：

  苄氧羰基-L-丙氨酸 在 溶剂黄146 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 生成 Z-Ala-Phe-OEt
  参考文献：
  名称：

  Fujino,M.; Nishimura,O., Chemical and pharmaceutical bulletin, 1969, vol. 17, p. 1937 - 1941

  摘要：

  DOI：

文献信息

• A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
  作者：Ian R. Baxendale、Steven V. Ley、Christopher D. Smith、Geoffrey K. Tranmer

  DOI：10.1039/b612197g

  日期：——

  A general flow process for the multi-step assembly of peptides has been developed and this procedure has been used to successfully construct a series of Boc, Cbz and Fmoc N-protected dipeptides in excellent yields and purities, including an extension of the method to enable the preparation of a tripeptide derivative.

  已经开发出一种用于多步骤肽组装的一般流程，该程序已成功用于构建一系列高收率和高纯度的Boc、Cbz和Fmoc N-保护的二肽，包括将该方法扩展至制备三肽衍生物。
• Aziridine-Mediated Ligation at Phenylalanine and Tryptophan Sites
  作者：Kiran Bajaj、Rajeev Sakhuja

  DOI：10.1002/asia.201700538

  日期：2017.8.4

  An efficient approach towards peptide synthesis that allows easy access to variety of small peptides via one-pot aziridine-mediated ligation/desulfurization strategy has been described. The protocol afforded a library of phenylalanine- and tryptophan-containing α-peptides in good yields by regioselective ring-opening of aziridine-3-aryl-2-carboxylates with peptide thioacids, followed by desulfurization

  已经描述了一种有效的肽合成方法，该方法允许通过一锅氮丙啶介导的连接/脱硫策略轻松获得各种小肽。该方案通过用肽硫代酸对氮丙啶-3-芳基-2-羧酸酯的区域选择性开环，然后进行脱硫，以高收率提供了含苯丙氨酸和色氨酸的α-肽文库。
• Derivatives of dipeptide and their use in determining the activity of
  申请人：Fujirebio Kabushiki Kaisha

  公开号：US04551272A1

  公开（公告）日：1985-11-05

  Derivatives of dipeptide having the following general formula and their use as substrates for colorimetrically or spectrophotometrically measuring the activity of carboxypeptidase A: ##STR1## wherein X is OH in ortho or para position, or NH.sub.2 or CH.sub.3 O in para position, Y is ##STR2##

  二肽衍生物具有以下一般式并且它们可作为颜色测定或光谱测定羧肽酶A活性的底物： ##STR1## 其中X在邻位或对位上为OH，或者在对位上为NH.sub.2或CH.sub.3 O，Y为 ##STR2##
• Dipeptide derivatives and their use in determining the activity of carboxypeptidase A
  申请人：FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC.

  公开号：EP0150227A1

  公开（公告）日：1985-08-07

  Dipeptide derivatives useful as substrates for colourimetrically or spectrophotometrically measuring the activity of carboxypeptidase A have the following general formula wherein X is OH in the ortho or para position, or NH2 or CH30 in the para position, Y is or

  可用作比色法或分光光度法测量羧肽酶 A 活性的底物的二肽衍生物具有以下通式 其中 X 是位于正位或对位的 OH，或位于对位的 NH2 或 CH30，Y 是或
• HMDO-Promoted Peptide and Protein Synthesis in Ionic Liquids
  作者：Jianli Duan、Yao Sun、Hao Chen、Guofu Qiu、Haibing Zhou、Ting Tang、Zixin Deng、Xuechuan Hong

  DOI：10.1021/jo400797t

  日期：2013.7.19

  Hexamethyldisiloxane (HMDO) has been developed to efficiently promote the metal-free direct coupling of an amino function of one cysteine-free peptide or protein and a C-terminal thioester of the second peptide in ionic liquids. The amide-coupling reaction proceeds smoothly under mild conditions to afford the corresponding products in good to excellent yields (63-94%). Peptide couplings were also achieved using in-situ-generated thioesters by the thioesterification of oxo esters.