tert-butyl N-[(2S)-1-oxo-1-(2-propan-2-yloxyethylamino)propan-2-yl]carbamate | 1161436-04-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl N-[(2S)-1-oxo-1-(2-propan-2-yloxyethylamino)propan-2-yl]carbamate
• CAS: 1161436-04-9
• 化学式: C₁₃H₂₆N₂O₄
• 分子量: 274.36
• InChiKey: LPUIWQWWCFVXKM-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-叔丁氧羰基-L-丙氨酸 、 2-isopropoxyethan-1-amine hydrochloride 在 咪唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 tert-butyl N-[(2S)-1-oxo-1-(2-propan-2-yloxyethylamino)propan-2-yl]carbamate
  参考文献：
  名称：

  ALPHA-AMINO-N-SUBSTITUTED AMIDES, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USES THEREOF

  摘要：

  公开号：

  EP2233467B1

文献信息

• Alpha-Amino-N-Substituted Amides, Pharmaceutical Composition Containing Them and Uses Thereof
  申请人：Nan Fajun

  公开号：US20110021624A1

  公开（公告）日：2011-01-27

  Disclosed are a series of α-amino-N-substituted amide compounds having a structure of the following formula, the pharmaceutically acceptable salts thereof, and the pharmaceutical composition comprising the same. The α-amino-N-substituted amide compounds or the pharmaceutically acceptable salts thereof according to the present invention have anti-tumor and/or anti-cancer activities in vivo and in vitro, can effectively depress the growth of various tumor cells and/or cancer cells, and thus can be used in preparing drugs for treating tumors and/or cancers.
• SUBSTITUTED BENZIMIDAZOLIUM COMPOUNDS USEFUL IN THE TREATMENT OF RESPIRATORY DISEASES
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20180105512A1

  公开（公告）日：2018-04-19

  The present invention relates to compounds of formula (I), or the tautomers or pharmacologically acceptable acid addition salts thereof, characterized by a topological polar surface area value (TPSA) of at least 145, wherein R 1 , R 2 , R 3 , R 4 , X, and Z − have one of the meanings as defined in the specification, to the use of compounds of formula (I) as a medicament, to pharmaceutical composition comprising at least one compound of formula (I), as well as to medicament combinations containing one or more compounds of formula (I).
• US8470763B2
  申请人：——

  公开号：US8470763B2

  公开（公告）日：2013-06-25
• ALPHA-AMINO-N-SUBSTITUTED AMIDES, PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USES THEREOF
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：EP2233467B1

  公开（公告）日：2012-09-19