total synthesis of the 34-hydroxyasimicin and its 3-(4-benzoylphenyl)propionate ester was achieved by means of a convergent synthetic strategy. This ester, which contains eight asymmetric centers, represents the first photoaffinity-labeling agent that is derived from an Annonaceous acetogenin. The key transformations in the synthesis include the Sharpless asymmetric dihydroxylation reaction, the Wittig
通过收敛的合成策略实现了3
4-羟基阿米霉素及其3-(
4-苯甲酰基苯基)
丙酸酯的不对称全合成。该
酯包含八个不对称中心,代表第一种衍生自无核产
乙酸原的光亲和标记剂。合成过程中的关键转变包括Sharpless不对称二羟基化反应,Wittig
烯烃化反应,
氧化rh(vii)的
氧化环化反应,Williamson醚化反应以及
钯催化的交叉偶联反应。