N-乙基邻甲苯磺酰胺 | 1077-56-1

• 物质功能分类: 化学试剂 - 有机试剂 - 酰胺
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: N-乙基邻甲苯磺酰胺
• 中文别名: N-乙基-2-甲基苯磺酰胺；乙基甲苯磺酰胺
• 英文名称: N-Ethyl(o-methyl)benzenesulfonamide
• 英文别名: N-ethyl-o-toluenesulfonamide；N-ethyl ortho-toluene sulfonamide；N-ethyl-2-methylbenzenesulfonamide
• CAS: 1077-56-1
• 化学式: C₉H₁₃NO₂S
• 分子量: 199.274
• InChiKey: NATWUQFQFMZVMT-UHFFFAOYSA-N

物化性质

• 熔点：
  18
• 沸点：
  317.2±35.0 °C(Predicted)
• 密度：
  1.153±0.06 g/cm3(Predicted)
• 闪点：
  345
• 物理描述：
  Liquid

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• TSCA：
  TSCA listed
• WGK Germany：
  3
• 海关编码：
  2935009090
• 安全说明：
  S26,S36

反应信息

• 作为反应物：
  描述：

  N-乙基邻甲苯磺酰胺 在 chromium(VI) oxide 、 高碘酸 作用下， 以 乙腈 为溶剂， 反应 8.0h， 以12%的产率得到2-乙基-1,1-二氧代-1,2-苯并噻唑-3-酮
  参考文献：
  名称：

  Oxidative cyclization of N-alkyl-o-methyl-arenesulfonamides to biologically important saccharin derivatives

  摘要：

  Various biologically important saccharin skeletons and their N-alkyl derivatives have been efficiently prepared by chromium(VI) oxide catalyzed H5IO6 oxidation of N-alkyl-o-methyl-arenesulfonamides in acetonitrile. N-tert-Butyl saccharin skeletons were easily prepared by H5IO6-CrO3 oxidation of N-tert-butyl-o-methyl arenesulfonamides in the presence of acetic anhydride. The method that furnished the novel fluoro and trifluoromethyl substituted saccharin skeletons is characterized by two steps, a simple work-up procedure, a single purification and good overall yields from substituted toluene derivatives. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.05.038
• 作为产物：
  描述：

  乙胺盐酸盐 、 邻甲苯磺酰氯 在 potassium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 1.0h， 生成 N-乙基邻甲苯磺酰胺
  参考文献：
  名称：

  铜催化的三氟甲基化和芳族磺酰基基团链烯烃的环化反应，用于构建1,2-苯并噻嗪烷二氧化物类化合物。

  摘要：

  多才多艺的系统：已开发出一种有效的铜催化串联的三氟甲基化/电子缺陷型芳香环的环。该方法提供了一种在温和的条件下合成三氟甲基化的1,2-苯并噻嗪烷二氧化物的强大而直接的方法（请参见方案）。通过一系列动力学实验和同位素标记研究研究了该机制。

  DOI：

  10.1002/chem.201303623

文献信息

• [EN] 2-CYANOISOINDOLINE DERIVATIVES FOR TREATING CANCER<br/>[FR] DÉRIVÉS DE 2-CYANOISOINDOLINE POUR LE TRAITEMENT DU CANCER
  申请人：MISSION THERAPEUTICS LTD

  公开号：WO2017158388A1

  公开（公告）日：2017-09-21

  The invention relates to novel compounds of formula I which are inhibitors of deubiquitylating enzymes (DUBs) and/or desumoylating enzymes. In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 7 or ubiquitin specific peptidase 7 (USP7). The invention further relates to methods for the preparation of these compounds and to their use in the treatment of cancer.

  这项发明涉及公式I的新化合物，这些化合物是去泛素化酶（DUBs）和/或去泛素化酶的抑制剂。具体来说，该发明涉及抑制泛素C端水解酶7或泛素特异性肽酶7（USP7）。该发明还涉及这些化合物的制备方法以及它们在癌症治疗中的应用。
• Infrared Spectra of Phenylsulfonyl Derivatives. (4). The Infrared Spectra of N-Acylsulfonamide Derivatives. (Organic Analysis. XLVIII)
  作者：Yo Ueda、Hiroshige Yano、Tsutomu Momose

  DOI：10.1248/cpb.12.5

  日期：——

  The splitting phenomenon of the carbonyl absorptions and the shifts of S-N stretching vibrations to a longer wave length region of some N-acyl-N-substituted-sulfonamide derivatives measured in solid state were described. Tertiary sulfonamides had their SO2 stretching vibrations at a shorter wave length region than secondary sulfonamides. N-Acetyl-N-alkylmethane (or ethane) sulfonamide showed strong C-N stretching vibrations of the group N-CH2-R at about 1125cm-1. N-Acyl-N-substituted-sulfonamide derivatives had very strong asymmetric stretching vibrations of the group C-CO-N at 1250∼1290cm-1. Synthesis of some sulfonamide derivatives is also described.

  在固态下测得的某些N-酰基-N-取代磺酰胺衍生物的羰基吸收分裂现象以及S-N伸缩振动向长波长区域的位移均有所描述。三级磺酰胺的SO2伸缩振动比二级磺酰胺位于更短的波长区域。N-乙酰基-N-烷基甲烷(或乙烷)磺酰胺在约1125cm-1处显示出强烈的N-CH2-R基团的C-N伸缩振动。N-酰基-N-取代磺酰胺衍生物在1250∼1290cm-1处具有非常强烈的C-CO-N基团的不对称伸缩振动。此外，还描述了一些磺酰胺衍生物的合成。
• POLYCONDENSATE, COMPOSITION, TREATMENT PROCESS, AND PREPARATION PROCESS
  申请人：Rodriguez Ivan

  公开号：US20080069786A1

  公开（公告）日：2008-03-20

  Polycondensate, composition containing it, especially a nail varnish composition, and process for preparation. The polycondensate may be obtained by reacting: a polyol comprising 3 to 6 hydroxyl groups; a saturated or unsaturated non-aromatic monocarboxylic acid; an aromatic monocarboxylic acid containing 7 to 11 carbon atoms; and a saturated or unsaturated, or even aromatic, linear, branched and/or cyclic polycarboxylic acid, comprising at least two carboxylic groups COOH; and/or a cyclic anhydride of such a polycarboxylic acid.

  聚缩酸酯、含有该聚缩酸酯的组合物，特别是指一种指甲油组合物，以及其制备方法。该聚缩酸酯可通过以下反应获得：包含3至6个羟基的多元醇；饱和或不饱和的非芳香族一元羧酸；含有7至11个碳原子的芳香族一元羧酸；以及含有至少两个羧基COOH的饱和或不饱和，甚至是芳香族的线性、分支和/或环状多羧酸；和/或这种多羧酸的环状酐。
• [EN] 3,6-DISUBSTITUTED AZABICYCLO HEXANE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS<br/>[FR] DERIVES DE 3,6-DISUBSTITUES AZABICYCLO HEXANE UTILISES EN TANT QU'ANTAGONISTES DU RECEPTEUR DE MUSCARINIQUE
  申请人：RANBAXY LAB LTD

  公开号：WO2004067510A1

  公开（公告）日：2004-08-12

  This invention generally relates to derivatives of 3,6 disubstituted azabicyclo hexanes.The compounds of this invention can function as muscarinic receptor antagonists and can be used for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors.The invention also relates to pharmaceutical compositions containing the compounds of the present invention and the methods of treating the diseases mediated through muscarinic receptors.

  这项发明通常涉及3,6-二取代氮杂环己烷衍生物。本发明的化合物可以作为毒蕈碱受体拮抗剂发挥作用，并可用于治疗通过毒蕈碱受体介导的呼吸道、泌尿道和消化系统的各种疾病。该发明还涉及含有本发明化合物的药物组合物以及治疗通过毒蕈碱受体介导的疾病的方法。
• Two-coat cosmetic product, cosmetic process of using thereof and makeup kit containing this product
  申请人：Blin Xavier

  公开号：US20050095213A1

  公开（公告）日：2005-05-05

  The present disclosure relates to a cosmetic product comprising at least one first and at least one second composition, the first composition comprising, in a cosmetically acceptable organic liquid medium, at least one film-forming linear ethylenic block polymer, and the second composition comprising a cosmetically acceptable medium. The present disclosure also relates to a makeup process and to a makeup kit containing the product. This product can be, for example, a lipstick, a mascara or a nail varnish.

  本公开涉及一种化妆品产品，包括至少一种第一组分和至少一种第二组分，其中第一组分在化妆上可接受的有机液体介质中包含至少一种成膜线性乙烯基块聚合物，第二组分包含化妆上可接受的介质。本公开还涉及一种化妆过程和包含该产品的化妆品套装。该产品可以是口红、睫毛膏或指甲油等。