2-trimethylsilylethyl (E)-2-methylbut-2-enoate | 920756-88-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-trimethylsilylethyl (E)-2-methylbut-2-enoate
• CAS: 920756-88-3
• 化学式: C₁₀H₂₀O₂Si
• 分子量: 200.353
• InChiKey: MJHKDXNTVZTYQH-RMKNXTFCSA-N

物化性质

• 沸点：
  236.1±23.0 °C(Predicted)
• 密度：
  0.885±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.83
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-trimethylsilylethyl (E)-2-methylbut-2-enoate 在 4-二甲氨基吡啶 、 AD-mix-α 作用下， 以 二氯甲烷 、 水 、 叔丁醇 为溶剂， 反应 2.0h， 生成 threo-trimethylsilylethyl 3-acetoxy-2-hydroxy-2-methylbutanoate
  参考文献：
  名称：

  Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica

  摘要：

  Four phenylpropanoids and a thapsigargin analogue have been isolated from the fruits of Thapsia garganica. A spectroscopic method for elucidating the relative stereochemistry at the two pairs of stereogenic centers in the phenylpropanoids has been developed. The phenylpropanoids were found to be potent cytotoxins. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2006.10.005
• 作为产物：
  描述：

  惕格酸 、 2-(三甲硅基)乙醇 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 反应 18.0h， 以67%的产率得到2-trimethylsilylethyl (E)-2-methylbut-2-enoate
  参考文献：
  名称：

  Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica

  摘要：

  Four phenylpropanoids and a thapsigargin analogue have been isolated from the fruits of Thapsia garganica. A spectroscopic method for elucidating the relative stereochemistry at the two pairs of stereogenic centers in the phenylpropanoids has been developed. The phenylpropanoids were found to be potent cytotoxins. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2006.10.005

文献信息

• Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica
  作者：Huizhen Liu、Kent Gunnertoft Jensen、Linh My Tran、Ming Chen、Lin Zhai、Carl Erik Olsen、Helmer Søhoel、Samuel R. Denmeade、John T. Isaacs、S. Brøgger Christensen

  DOI：10.1016/j.phytochem.2006.10.005

  日期：2006.12

  Four phenylpropanoids and a thapsigargin analogue have been isolated from the fruits of Thapsia garganica. A spectroscopic method for elucidating the relative stereochemistry at the two pairs of stereogenic centers in the phenylpropanoids has been developed. The phenylpropanoids were found to be potent cytotoxins. (c) 2006 Elsevier Ltd. All rights reserved.