(2E,8E)-10-((E)-2-methylbut-2-enoyloxy)deca-2,8-diene-4,6-diynoic acid methyl ester | 1192834-80-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2E,8E)-10-((E)-2-methylbut-2-enoyloxy)deca-2,8-diene-4,6-diynoic acid methyl ester
• 英文别名: methyl (2E,8E)-10-[(E)-2-methylbut-2-enoyl]oxydeca-2,8-dien-4,6-diynoate
• CAS: 1192834-80-2
• 化学式: C₁₆H₁₆O₄
• 分子量: 272.301
• InChiKey: BYGJMPLSVFUVSR-NSVSABEVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  惕格酸 、 (2E,8E)-10-hydroxydeca-2,8-diene-4,6-diynoic acid methyl ester 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以79%的产率得到(2E,8E)-10-((E)-2-methylbut-2-enoyloxy)deca-2,8-diene-4,6-diynoic acid methyl ester
  参考文献：
  名称：

  Synthesis of isomeric polyacetylenes based on natural hydroxy matricaria esters

  摘要：

  The construction of a library of natural and related polyacetylenes using a convergent synthetic strategy based on a palladium mediated cross-coupling reaction is described. The systematic synthetic study led to all possible alkene isomers of the hydroxy matricaria esters 29-32, and the corresponding tiglates 1-4. The synthesis of many of these compounds is described for the first time. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.07.082

文献信息

• Synthesis of isomeric polyacetylenes based on natural hydroxy matricaria esters
  作者：Solange Garrais、Jennifer Turkington、William P.D. Goldring

  DOI：10.1016/j.tet.2009.07.082

  日期：2009.10

  The construction of a library of natural and related polyacetylenes using a convergent synthetic strategy based on a palladium mediated cross-coupling reaction is described. The systematic synthetic study led to all possible alkene isomers of the hydroxy matricaria esters 29-32, and the corresponding tiglates 1-4. The synthesis of many of these compounds is described for the first time. (C) 2009 Elsevier Ltd. All rights reserved.