(3R)-1-benzyl-3-(4-methoxyphenyl)-3-methylpyrrolidine-2,5-dione | 889102-18-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (3R)-1-benzyl-3-(4-methoxyphenyl)-3-methylpyrrolidine-2,5-dione
• CAS: 889102-18-5
• 化学式: C₁₉H₁₉NO₃
• 分子量: 309.365
• InChiKey: PLDMLGQJCAVCKH-LJQANCHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3R)-1-benzyl-3-(4-methoxyphenyl)-3-methylpyrrolidine-2,5-dione 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 25.0h， 生成
  参考文献：
  名称：

  Rhodium-Catalyzed Asymmetric Construction of Quaternary Carbon Stereocenters:  Ligand-Dependent Regiocontrol in the 1,4-Addition to Substituted Maleimides

  摘要：

  A rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to substituted maleimides has been described. The regioselectivity in this reaction is controlled by the choice of ligand (dienes or bisphosphines), and 1,4-adducts with a quaternary stereocenter can be obtained with high regio- and enantioselectivity by the use of (R)-H8-binap.

  DOI：

  10.1021/ja061430d
• 作为产物：
  描述：

  柠康酸酐 在 氢氧化钾 、 bis(ethylene)rhodium(I) chloride dimer 、 溶剂黄146 、 C.I.酸性棕21 作用下， 以 1,4-二氧六环 为溶剂， 反应 7.0h， 生成 (3R)-1-benzyl-3-(4-methoxyphenyl)-3-methylpyrrolidine-2,5-dione
  参考文献：
  名称：

  Rhodium-Catalyzed Asymmetric Construction of Quaternary Carbon Stereocenters:  Ligand-Dependent Regiocontrol in the 1,4-Addition to Substituted Maleimides

  摘要：

  A rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to substituted maleimides has been described. The regioselectivity in this reaction is controlled by the choice of ligand (dienes or bisphosphines), and 1,4-adducts with a quaternary stereocenter can be obtained with high regio- and enantioselectivity by the use of (R)-H8-binap.

  DOI：

  10.1021/ja061430d

文献信息

• Rhodium-Catalyzed Asymmetric Construction of Quaternary Carbon Stereocenters:  Ligand-Dependent Regiocontrol in the 1,4-Addition to Substituted Maleimides
  作者：Ryo Shintani、Wei-Liang Duan、Tamio Hayashi

  DOI：10.1021/ja061430d

  日期：2006.5.1

  A rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to substituted maleimides has been described. The regioselectivity in this reaction is controlled by the choice of ligand (dienes or bisphosphines), and 1,4-adducts with a quaternary stereocenter can be obtained with high regio- and enantioselectivity by the use of (R)-H8-binap.