N,N-二(羧甲基)甘氨酸铅(2+)盐 | 53113-59-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N,N-二(羧甲基)甘氨酸铅(2+)盐
• 英文名称: 2-(4,8-dioxo-1,3,6,2λ2-dioxazaplumbocan-6-yl)acetic acid
• CAS: 53113-59-0
• 化学式: C₆H₇NO₆*Pb
• 分子量: 396.325
• InChiKey: HOUDIAKCTRMSHT-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.51
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  7

ADMET

毒理性

• 致癌性证据

A3; 已确认的动物致癌物，对人类的相关性未知。

A3; Confirmed animal carcinogen with unknown relevance to humans.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

铅、铅化合物：合理预期为人类致癌物

Lead, lead compounds: Reasonably anticipated to be a human carcinogen

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

神经毒素 - 主要影响运动功能 职业性肝毒素 - 次级肝毒素：职业环境中潜在毒性效应的判断基于人类摄入或动物实验的中毒案例。 肾毒素 - 该化学物质在职业环境中可能对肾脏有毒。 生殖毒素 - 对生殖系统有毒的化学物质，包括对后代缺陷和男性或女性生殖功能的损害。生殖毒性包括发育效应。参见生殖毒性风险评估指南。

Neurotoxin - Predominantly motor Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting. Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

立即急救：确保已经进行了充分去污。如果患者停止呼吸，开始人工呼吸，最好使用需求阀复苏器、气囊面罩装置或口袋面罩，按训练进行操作。根据需要执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果发生呕吐，让患者前倾或置于左侧（如果可能的话，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗帮助。/铅及其相关化合物/

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Lead and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

基本治疗：建立专利气道（如需要，使用口咽或鼻咽气道）。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测休克并如有必要进行治疗……预见癫痫发作并如有必要进行治疗……对于眼睛污染，立即用水冲洗眼睛。在转运过程中，用0.9%的生理盐水（NS）持续冲洗每只眼睛……不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……给予活性炭……/铅及其相关化合物/

Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Administer activated charcoal ... . /Lead and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  N,N-二(羧甲基)甘氨酸铅(2+)盐 、 potassium hydroxide 以 水 为溶剂， 以100%的产率得到N,N-Bis(carboxymethyl)glycine lead(2+) potassium salt (1:1:1)
  参考文献：
  名称：

  Bogatyrev, A. B.; Shokhor, I. N.; Burkat, G. K., Journal of applied chemistry of the USSR, 1981, vol. 54, p. 1701 - 1705

  摘要：

  DOI：
• 作为产物：
  描述：

  {Pb(C6H6NO6)}(1-) 以 溶剂黄146 为溶剂， 生成 N,N-二(羧甲基)甘氨酸铅(2+)盐
  参考文献：
  名称：

  Bogatyrev, A. B.; Shokhor, I. N.; Burkat, G. K., Journal of applied chemistry of the USSR, 1981, vol. 54, p. 1701 - 1705

  摘要：

  DOI：