Antimon-triacetat

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Antimon-triacetat
• 英文别名: Diacetyloxystibanyl acetate
• 化学式: C₆H₉O₆Sb
• 分子量: 298.884
• InChiKey: JVLRYPRBKSMEBF-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  -4.11
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  120
• 氢给体数：
  0
• 氢受体数：
  6

ADMET

代谢

锑在人体内广泛分布。头发和皮肤含有最高的锑水平。肾上腺、肺、大肠、气管、小脑和肾脏也含有相对较高的锑。血液是将吸收的锑运输到身体各个组织隔室的主要载体。锑是一种金属，因此不会发生分解代谢。锑可以与巯基和磷酸共价相互作用，以及与许多内源性配体（例如，蛋白质）进行可逆的绑定相互作用。目前尚不清楚这些相互作用在毒理学上是否具有重要意义。锑通过尿液和粪便排出。部分粪便中的锑可能代表未被吸收的锑，这些锑通过粘液纤毛活动从肺部清除到食管，再进入胃肠道。（L741）

Antimony is widely distributed throughout the body. The hair and skin contain the highest levels of antimony. The adrenal glands, lung, large intestine, trachea, cerebellum, and kidneys also contain relatively high levels of antimony. Blood is the main vehicle for the transport of absorbed antimony to various tissue compartments of the body. Antimony is a metal and, therefore, does not undergo catabolism. Antimony can covalently interact with sulfhydryl groups and phosphate, as well as numerous reversible binding interactions with endogenous ligands (e.g., proteins). It is not known if these interactions are toxicologically significant. Antimony is excreted via the urine and feces. Some of the fecal antimony may represent unabsorbed antimony that is cleared from the lung via mucociliary action into the esophagus to the gastrointestinal tract. (L741)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

吸入数据表明心肌是锑中毒的目标。锑可能通过干扰糖原分解和糖异生途径的酶来影响循环中的葡萄糖。锑的作用机制尚不清楚。然而，一些研究表明，锑与巯基团结合，包括一些对组织呼吸重要的酶中的巯基团。BAL的解毒作用取决于其阻止或打断锑与关键酶结合的能力。此外，死亡原因被认为是与急性砷中毒基本相同。(T18, L741, A238)

The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes of the glycogenolysis and gluconeogenesis pathways. The mechanism of action of antimony remains unclear. However, some studies suggest that antimony combines with sulfhydryl groups including those in several enzymes important for tissue respiration. The antidotal action of BAL depends on its ability to prevent or break the union between antimony and vital enzymes. Moreover, the The cause of death is believed to be essentially the same as that in acute arsenic poisoning. (T18, L741, A238)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

无致癌性迹象（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity (not listed by IARC). (L135)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

皮肤接触锑可以导致锑斑（围绕汗腺和皮脂腺的丘疹和脓疱）。锑中毒还可能导致肺尘埃沉着病。吸入锑可能导致肺部功能改变和其他影响，包括慢性支气管炎、慢性肺气肿、活动性肺结核、胸膜粘连和刺激。锑中毒还可能导致血压升高。心肌抑制、血管扩张和体液流失可能导致低血压、电解质紊乱和急性肾衰竭的休克。脑水肿、昏迷、抽搐和死亡也是可能的。（L741）

Dermal exposure to antimony can cause antimony spots (papules and pustules around sweat and sebaceous glands). Antimony poisoning can also lead to pneumoconiosis. Alterations in pulmonary function and other effects including chronic bronchitis, chronic emphysema, inactive tuberculosis, pleural adhesions, and irritation can result from inhalation of antimony. Increased blood pressure can also result from antimony poisoning. Myocardial depression, vasodilation and fluid loss may cause shock with hypotension, electrolyte disturbances and acute renal failure. Cerebral oedema, coma, convulsions, and death are possible. (L741)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

吸入（L741）；口服（L741）；皮肤给药（L741）

Inhalation (L741) ; oral (L741) ; dermal (L741)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

腹部疼痛、呕吐、腹泻可能是由吸入锑引起的。呼吸困难、头痛、呕吐、咳嗽、结膜炎和鼻出血脓性分泌物可能是由吸入暴露引起的。皮肤或眼睛接触可能会导致暴露表面疼痛和发红。（T64, L741）

Abdominal pain, vomiting, diarrhea can result from inhalation of antimony. Dyspnea, headache, vomiting,cough, conjunctivitis, and bloody purulent discharge from nose can result from inhalation exposure. Skin or eye contact can cause pain and redness of the exposed surface. (T64, L741)

来源:Toxin and Toxin Target Database (T3DB)

反应信息

• 作为反应物：
  描述：

  Antimon-triacetat 生成 antimony trioxide
  参考文献：
  名称：

  IVERS-TIFFEE, ELLEN;SEITZ, KATHARINA, AMER. CERAM. SOC. BULL., 66,(1987) N 9, 1384-1388

  摘要：

  DOI：
• 作为产物：
  描述：

  三苯基锑 、 溶剂黄146 在 copper(II) nitrate 作用下， 以 甲苯 为溶剂， 生成 Antimon-triacetat
  参考文献：
  名称：

  Dodonov, V. A.; Gushchin, A. V.; Bolotova, O. P., Journal of general chemistry of the USSR, 1990, vol. 60, p. 1858 - 1862

  摘要：

  DOI：

文献信息

• Aminolysis of Triphenylantimony Dicarboxylates and Its Application to Catalytic Amidation
  作者：Ryoki Nomura、Takao Wada、Yasuhiro Yamada、Haruo Matsuda

  DOI：10.1246/cl.1986.1901

  日期：1986.11.5

  Triphenylantimony dicarboxylates (Ph3Sb(O2CR)2, where R=Me, CF3, Ph and CH2NH-Z) readily reacted with amines (R′NH2, where R′=n-C6H13, s-Bu, C6H11, and Ph) to afford corresponding amides and triphenylstibine oxide in fairly good yields. The amidation of RCO2H with R′NH2 was also catalyzed by the orgnoantimony compounds.

  三苯基锑二羧酸盐（Ph3Sb(O2CR)2，其中 R=Me、CF3、Ph 和 CH2NH-Z）容易与胺（R'NH2，其中 R'=n-C6H13、s-Bu、C6H11 和 Ph）反应得到相应的酰胺和三苯基氧化锑，收率相当好。RCO2H与R'NH2的酰胺化也由有机锑化合物催化。
• Modified copolyesters and optical films including modified copolyesters
  申请人：Hebrink J. Timothy

  公开号：US20060084780A1

  公开（公告）日：2006-04-20

  Modified copolyesters having relatively low refractive indices and relatively high glass transition temperatures are disclosed. These modified copolyesters can be used in forming one or more layers in an optical film, such as a multilayer polymer film.

  本发明揭示了具有相对较低折射率和相对较高玻璃转移温度的改性共聚酯。这些改性共聚酯可以用于形成光学薄膜中的一个或多个层，例如多层聚合物薄膜。
• Catalyst and process for selective hydrogenation
  申请人：Lowe M. David

  公开号：US20050113614A1

  公开（公告）日：2005-05-26

  A selective hydrogenation catalyst composition comprises at least two different metal components selected from Groups 8 to 10 of the Periodic Table of Elements, one of which may be rhodium, and at least one metal component selected from Group 13 of the Periodic Table of Elements, such as indium.

  一种选择性加氢催化剂组成物包括至少来自元素周期表8至10族的至少两种不同金属组分，其中一种可以是铑，以及来自元素周期表13族的至少一种金属组分，例如铟。
• MODIFIED COPOLYESTERS AND OPTICAL FILMS INCLUDING MODIFIED COPOLYESTERS
  申请人：Hebrink Timothy J.

  公开号：US20080145666A1

  公开（公告）日：2008-06-19

  Modified copolyesters having relatively low refractive indices and relatively high glass transition temperatures are disclosed. These modified copolyesters can be used in forming one or more layers in an optical film, such as a multilayer polymer film.

  本发明揭示了具有相对较低折射率和相对较高玻璃化转变温度的改性共聚酯。这些改性共聚酯可用于形成光学薄膜中的一个或多个层，例如多层聚合物薄膜。
• Low-Bandgap Cs₄CuSb₂Cl₁₂Layered Double Perovskite: Synthesis, Reversible Thermal Changes, and Magnetic Interaction
  作者：Nancy Singhal、Rayan Chakraborty、Prasenjit Ghosh、Angshuman Nag

  DOI：10.1002/asia.201800635

  日期：2018.8.16

  response of CuII d9 electrons controlling the optoelectronic properties. A simple grinding of precursor salts at ambient conditions provides a stable and scalable product. CCSC is stable in water/acetone solvent mixtures (≈30 % water) and many other polar solvents unlike Pb‐halide perovskites. It decomposes to Cs3Sb2Cl9, Cs2CuCl4, and SbCl3 at 210 °C, but the reaction can be reversed back to produce CCSC

  现在正在研究具有通式A 2 M'（I）M III X 6（A和M为金属离子，X = Cl，Br，I）的双钙钛矿（DPs）作为卤化钙钛矿的潜在替代品。太阳能电池和其他光电应用。然而，这些DP通常遭受宽（≈3eV）和/或间接带隙的困扰。2017年，报道了一种新的结构变体，即用二价Cu II离子代替M'（I）的层状卤化物DP Cs 4 CuSb 2 Cl 12（CCSC），其带隙约为1 eV。在这里，我们报告CCSC的机械化学合成，其热和化学稳定性以及Cu II d 9的磁响应。电子控制光电特性。在环境条件下对前体盐进行简单研磨即可提供稳定且可扩展的产品。CCSC在水/丙酮混合溶剂（约30％的水）和许多其他极性溶剂中稳定，与Pb-卤化物钙钛矿不同。分解为Cs 3 Sb 2 Cl 9，Cs 2 CuCl 4和SbCl 3在210°C下进行反应，但反应可以逆转以在较低的温度和较高的湿度下产生CCSC

表征谱图