4-[methoxy-[(E)-4-methyl-5-(oxan-2-yloxy)pent-3-enyl]phosphoryl]morpholine | 1056987-32-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-[methoxy-[(E)-4-methyl-5-(oxan-2-yloxy)pent-3-enyl]phosphoryl]morpholine
• CAS: 1056987-32-6
• 化学式: C₁₆H₃₀NO₅P
• 分子量: 347.392
• InChiKey: QFUAZEGFNKETTK-GIDUJCDVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-[methoxy-[(E)-4-methyl-5-(oxan-2-yloxy)pent-3-enyl]phosphoryl]morpholine 在 四丁基氢氧化铵 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  [EN] NOVEL POLYMORPHIC FORM OF CHDMAPP, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
  [FR] NOUVELLE FORME POLYMORPHE DE CHDMAPP, SON PROCÉDÉ DE PRÉPARATION, ET COMPOSITION PHARMACEUTIQUE LA CONTENANT

  摘要：

  本发明涉及(2E)-1-羟基-2-甲基戊-2-烯基焦磷酸二钠(CHDMAPP-Na2)的新型多晶形态、其制备方法以及含有它们的药物组合物。

  公开号：

  WO2010029062A1
• 作为产物：
  描述：

  一氧化异戊二烯 在 4-甲基苯磺酸吡啶 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 生成 4-[methoxy-[(E)-4-methyl-5-(oxan-2-yloxy)pent-3-enyl]phosphoryl]morpholine
  参考文献：
  名称：

  [EN] ADJUVANT COMPOSITION AND METHODS FOR ITS USE
  [FR] COMPOSITION ADJUVANTE ET METHODES D'UTILISATION CORRESPONDANTES

  摘要：

  本发明涉及一种改善疫苗效力的疫苗佐剂。更具体地说，本发明涉及将ϜδT淋巴细胞激活剂用作疫苗佐剂，以促进和增强特定抗原的免疫反应，以及包含ϜδT淋巴细胞激活剂的疫苗组合物。

  公开号：

  WO2005102385A1

文献信息

• [EN] COMPOSITION AND METHOD FOR THE TREATMENT OF CARCINOMA<br/>[FR] COMPOSITION ET PROCEDE POUR LE TRAITEMENT DE CARCINOME
  申请人：INNATE PHARMA

  公开号：WO2005077411A3

  公开（公告）日：2006-04-13
• Composition and method for the treatment of carcinoma
  申请人：Romagne Francois

  公开号：US20070134273A1

  公开（公告）日：2007-06-14

  The present invention relates to compositions and methods useful for treating a carcinoma or viral infection in mammals, including humans. The methods and compositions typically comprise use of an immunogenic or immunomodulatory compound, and a gamma delta T cell activator, such that the composition is effective for treating a carcinoma or viral infection. In a preferred aspect of the invention, the methods comprise use of a gamma delta T cell activator and a Mycobacterium antigen, which for example is an attenuated strain of Mycobacterium bovis ( Bacillus Calmette-Guerin (BCG)).
• Adjuvant Composition and Methods for Its Use
  申请人：Tiollier Jerome

  公开号：US20070218086A1

  公开（公告）日：2007-09-20

  The present invention is directed to a vaccine adjuvant which improves the vaccine potency. More specifically, the present invention is directed to the use of a γδT lymphocyte activator as vaccine adjuvant to promote and enhance antigen specific immunological responses, as well as a vaccine composition comprising a γδT lymphocyte activator.
• [EN] ADJUVANT COMPOSITION AND METHODS FOR ITS USE<br/>[FR] COMPOSITION ADJUVANTE ET METHODES D'UTILISATION CORRESPONDANTES
  申请人：INNATE PHARMA

  公开号：WO2005102385A1

  公开（公告）日：2005-11-03

  The present invention is directed to a vaccine adjuvant which improves the vaccine potency. More specifically, the present invention is directed to the use of a ϜδT lymphocyte activator as vaccine adjuvant to promote and enhance antigen specific immunological responses, as well as a vaccine composition comprising a ϜδT lymphocyte activator.

  本发明涉及一种改善疫苗效力的疫苗佐剂。更具体地说，本发明涉及将ϜδT淋巴细胞激活剂用作疫苗佐剂，以促进和增强特定抗原的免疫反应，以及包含ϜδT淋巴细胞激活剂的疫苗组合物。
• [EN] NOVEL POLYMORPHIC FORM OF CHDMAPP, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME<br/>[FR] NOUVELLE FORME POLYMORPHE DE CHDMAPP, SON PROCÉDÉ DE PRÉPARATION, ET COMPOSITION PHARMACEUTIQUE LA CONTENANT
  申请人：INNATE PHARMA

  公开号：WO2010029062A1

  公开（公告）日：2010-03-18

  The present invention relates to novel polymorphs of (2E)-1-hydroxy-2-methylpent-2-enyl-pyrophosphonate disodium (CHDMAPP-Na2), to the process for preparing them and to the pharmaceutical compositions containing them.

  本发明涉及(2E)-1-羟基-2-甲基戊-2-烯基焦磷酸二钠(CHDMAPP-Na2)的新型多晶形态、其制备方法以及含有它们的药物组合物。