methyl laureohydroxamic acid | 52753-89-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl laureohydroxamic acid
• 英文别名: N-Hydroxy-N-methyldodecaneamide；N-Lauroyl-N-methyl-hydroxamsaeure；N-Methyl-N-lauroyl-hydroxamsaeure；Dodecanamide, N-hydroxy-N-methyl-；N-hydroxy-N-methyldodecanamide
• CAS: 52753-89-6
• 化学式: C₁₃H₂₇NO₂
• 分子量: 229.363
• InChiKey: LLRGNQSEJWROPH-UHFFFAOYSA-N

物化性质

• 沸点：
  329.1±25.0 °C(Predicted)
• 密度：
  0.936±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-甲基羟胺 、 alkaline earth salt of/the/ methylsulfuric acid 在 Lipozyme TL IM 作用下， 以 正己烷 、 水 为溶剂， 反应 72.0h， 生成 methyl oleohydroxamic acid 、 N-羟基-N-甲基十四烷酰胺 、 methyl laureohydroxamic acid
  参考文献：
  名称：

  Enzymatic Synthesis of Fatty Hydroxamic Acid Derivatives Based on Palm Kernel Oil

  摘要：

  使用 Lipozyme TL IM 催化剂在双相介质中合成脂肪羟肟酸衍生物，棕榈仁油溶于正己烷，羟胺衍生物溶于水：(1) N-甲基脂肪羟肟酸 (MFHAs)；(2) N-异丙基脂肪羟肟酸 (IPFHAs) 和 (3) N-苄基脂肪羟肟酸 (BFHAs) 分别由棕榈仁油和 N-甲基羟胺 (N-MHA)、N-异丙基羟胺 (N-IPHA) 和 N-苄基羟胺 (N-BHA) 反应合成。最后，通过颜色测试、元素分析、傅立叶变换红外光谱和 1H-NMR 光谱对分离后的产品进行表征。为了获得最高的产品转化率，在其他反应参数保持不变的情况下，通过改变反应物的比例获得了最佳的反应物摩尔比。合成 MFHA 时，N-MHA/棕榈仁油的最佳摩尔比为 6/1，最高转化率为 77.8%；合成 IPFHA 时，N-IPHA/棕榈仁油的最佳摩尔比为 7/1，最高转化率为 65.4%；合成 BFHA 时，N-BHA/棕榈仁油的最佳摩尔比为 7/1，最高转化率为 61.7%。

  DOI：

  10.3390/molecules16086634

文献信息

• Hydroxamate bleach stabilizer
  申请人：MONSANTO COMPANY

  公开号：EP0384912A2

  公开（公告）日：1990-08-29

  There are disclosed compositions comprising peroxygen containing bleach systems containing a bleach stabilizing amount of compound represented by the formula wherein R is selected from the group consisting of optionally substituted straight and branched chained alkyl C₁-₂₁, alkenyl C₁-₂₁, hydrogen, and optionally substituted phenyl groups, and wherein each R˝ is independently selected from groups consisting of hydrogen, alkyl C₁-₂₁ and alkenyl C₁-₂₁, provided that the total number of carbons in both R˝ groups is not greater than 21, each X is independently selected from hydrogen and SO₃ and Z is selected from the group consisting of hydroxy, alkoxy C₁-5 and alkenoxy C₁-₅, -O⁻M⁺, -NR₂‴ wherein each R‴ is independently selected from the group consisting of hydrogen, alkyl C₁-₅ or alkenyl C₁-₅, and R′ is selected from the group consisting of hydrogen, optionally substituted straight and branched chained alkyl C₁-₂₁, alkenyl C₁-₂₁ and an optionally substituted phenyl group, provided only one of R and R′ is hydrogen said stabilizer having a hydrophile-lipophile (HLB) balance within the same range as the HLB of said compounds wherein R is an unsubstituted C₁-₂₁ alkyl group and R′ is hydrogen or an unsubstituted C₁-₆ alkyl group, M is selected from hydrogen and a non-­interfering cation, and further provided that when M⁺ represents hydrogen and the composition contains a detergent active agent, the bleaching agent is selected from an inorganic peroxy compounds and bleach activator combination or an organic peroxy acid.

  本发明公开了由含过氧的漂白剂体系组成的组合物，该体系含有一定量的漂白剂稳定剂，该化合物由式表示 其中 R 选自任选取代的直链和支链烷基 C₁-₂₁、烯基 C₁-₂₁、氢和任选取代的苯基组成的组，以及 其中每个 R˝独立选自由氢、C₁-₂₁烷基和 C₁-₂₁ 烯基组成的基团，条件是两个 R˝ 基团中的碳总数不大于 21，每个 X 独立选自由氢和 SO₃，Z 选自由羟基组成的基团、烷氧基 C₁-5、烯氧基 C₁-₅、-O-M⁺、-NR₂‴，其中每个 R‴ 独立选自由氢组成的组、烷基 C₁-₅或烯基 C₁-₅，且 R′选自由氢、任选取代的直链和支链烷基 C₁-₂₁组成的组、烯基 C₁-₂₁和任选取代的苯基、只要 R 和 R′中只有一个是氢，所述稳定剂具有与所述化合物的 HLB 相同范围内的亲水-亲脂（HLB）平衡，其中 R 是未取代的 C₁-₂₁烷基，R′是氢或未取代的 C₁-₆烷基、M 选自氢和非干扰性阳离子，条件是当 M⁺ 代表氢且组合物含有洗涤活性剂时，漂白剂选自无机过氧化合物和漂白活化剂组合或有机过氧酸。
• Improved detergent compositions
  申请人：MONSANTO EUROPE S.A.

  公开号：EP0388389A2

  公开（公告）日：1990-09-19

  A detergent composition which is a bleach-free, under-built composition containing at least one surfactant and having a sequestration value such that an aqueous solution containing 7000 ppm of the detergent composition sequesters a maximum of 30 mg CaO per gram of detergent composition at 20°C, is characterised in that the composition contains a hydroxamic acid or a salt thereof, the hydroxamic acid having the formula R--R′ where R represents an optionally substituted straight- or branched chain C₅₋₂₁ alkyl or C₅₋₂₁ alkenyl group or an optionally-­substituted phenyl group, and R′ represents hydrogen, an optionally substituted C₁₋₆ alkyl group, or an optionally-­substituted phenyl group, but with the limitation that the hydroxamic acid has a hydrophile-lipophile balance (HLB) within the same range as the range of HLB's of hydroxamic acids of the above formula wherein R is an unsubstituted C₅₋₂₁ alkyl group and R′ is hydrogen or an unsubstituted C₁₋₆ alkyl group. Typical hydroxamic acids are dodecanohydroxamic acid and N-methyl dodecanohydroxamic acid.

  一种洗涤剂组合物，它是一种不含漂白剂的底层组合物，含有至少一种表面活性剂，并具有一定的螯合值，使含有 7000 ppm 该洗涤剂组合物的水溶液在 20°C 时每克洗涤剂组合物最多可螯合 30 毫克 CaO，其特征在于该组合物含有羟肟酸或其盐，羟肟酸的式为 R--R′ 其中 R 代表任选取代的直链或支链 C₅₋₂₁ 烷基或 C₅₋₂₁ 烯基或任选取代的苯基，R′ 代表氢、任选取代的 C₁₋₆ 烷基或任选取代的苯基、但羟肟酸的亲水-亲脂平衡（HLB）必须与上式羟肟酸的 HLB 范围相同，其中 R 是未取代的 C₅₋₂₁烷基，R′是氢或未取代的 C₁₋₆烷基。典型的羟肟酸是十二烷氧基羟肟酸和 N-甲基十二烷氧基羟肟酸。
• Hydroxamates
  申请人：E.R. Squibb & Sons, Inc.

  公开号：EP0200377B1

  公开（公告）日：1991-10-09
• US4604407A
  申请人：——

  公开号：US4604407A

  公开（公告）日：1986-08-05
• [EN] NOVEL COSMETIC COMPOSITIONS<br/>[FR] NOUVELLES COMPOSITIONS COSMETIQUES
  申请人：DSM IP ASSETS BV

  公开号：WO2006029818A2

  公开（公告）日：2006-03-23

  The present invention is directed to cosmetic compositions comprising a compound of the general formula (I) wherein L is hydrogen, branched alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, hy­droxyl, OR, HO-(CH2-CH2-O)n, HO-(CH2-O)n, HO-(CH2-CH2-CH2-O)n, HO­(CH2-CH(CH3)-O)n, HO-(CH(CH3)-CH2-O)n, NR4R5, C(O)NR6R7, with R being C1-4-alkyl or C2-18-alkanoyl; n being an integer from 1 to 8; R4, R5, R6 and R7 being independently from each other hydrogen or C1-18-alkyl; R1 is alkylene, alkenylene or alkinylene, optionally substituted with one or more methyl or ethyl groups; R2 is hydrogen or alkyl; and R3 is hydrogen, alkyl, or a cosmetically acceptable cation; and a carrier conventionally used in cosmetic compositions. The compositions preferably comprise additionally a retinoid. The present invention concerns further inter alia the use of such compositions for the treatment or prevention of any symptoms caused by negative developments of the physiological homeostasis of healthy skin, as wel as for the promotion of hair growth and protection from hair loss.