2,2'-bis(ethoxycarbonylmethoxy)biphenyl | 73429-10-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-bis(ethoxycarbonylmethoxy)biphenyl
• 英文别名: diethyl 2,2'-(biphenyl-2,2'-diylbis(oxy))diacetate；Diethyl-biphenyl-2,2'-bis-oxyacetat；Diethyl 2,2'-(biphenyl-2,2'-diyldioxy)diacetate；ethyl 2-[2-[2-(2-ethoxy-2-oxoethoxy)phenyl]phenoxy]acetate
• CAS: 73429-10-4
• 化学式: C₂₀H₂₂O₆
• 分子量: 358.391
• InChiKey: LYZNDVBTACLXKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,2'-bis(ethoxycarbonylmethoxy)biphenyl 在 lithium aluminium tetrahydride 、 sodium methylate 、 三乙胺 、 lithium bromide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 13.0h， 生成 2,2'-(2,2'-(biphenyl-2,2'-diylbis(oxy))bis(ethane-2,1-diyl))bis(sulfanediyl)diethanamine
  参考文献：
  名称：

  Synthesis and biological evaluation of diamide derivatives of (S)-BINOL and biphenyl as potential anti-inflammatory/anti-arthritic agents

  摘要：

  A series of (S)-BINOL and biphenyl based diamides have been synthesized and characterized from analytic and spectral data. Anti-arthritic activity was studied by inhibition of protein denaturation method (Bovine serum albumin). All the diamides exhibit excellent anti-arthritic activity. Anti-inflammatory activity of the diamides synthesized was investigated using human red blood cells membrane stabilization method, and some of the diamides exhibit good anti-inflammatory activity.

  DOI：

  10.1007/s00044-012-0410-6
• 作为产物：
  描述：

  2,2'-二羟基联苯 、 溴乙酸乙酯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 8.0h， 生成 2,2'-bis(ethoxycarbonylmethoxy)biphenyl
  参考文献：
  名称：

  联苯衍生物的合成，表征以及植物毒性和抗真菌活性

  摘要：

  合成，表征和评估了三个系列的联苯衍生物的Lemna次要植物毒性和抗真菌活性。合成的联苯类似物2c和6c表现出显着的活性，而化合物4b和6b表现出高活性。化合物2c和6c可以被认为是基于联芳基的潜在植物毒性剂。根据体外抗真菌生物测定，化合物2b，2e和6b表现出中等活性。

  DOI：

  10.1134/s1070363218100249

文献信息

• The formation of complexes between aza-derivatives of crown ethers and primary alkylammonium salts. Part 5. Chiral macrocyclic diamines
  作者：David P. J. Pearson、Stephen J. Leigh、Ian O. Sutherland

  DOI：10.1039/p19790003113

  日期：——

  analogous to crown ethers, are described. The chirality of these systems is based, in one case, upon the plane of chirality of paracyclophane systems and, in the other two cases, upon the axis of chirality of bridged biphenyls. Two methods are described for the measurement of chiral selectivity in the formation of complexes between these chiral macrocyclic host molecules and chiral guest primary alkylammonium

  描述了类似于冠醚的三种类型的手性大环二胺的合成。在一种情况下，这些系统的手性基于对环烷系统的手性平面，而在另两种情况下，则基于桥联联苯的手性轴。描述了两种方法，用于测量这些手性大环主体分子与手性客体伯烷基铵盐之间形成络合物的手性选择性。两种方法都使用nmr光谱法，单相系统，外消旋手性宿主以及（R）-和（RS）-客体盐。第一种方法既适用于光学不稳定的宿主，也适用于光学稳定的宿主，第二种方法仅适用于光学不稳定的宿主物种。
• Singh; Sharma; Malik, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 11, p. 1104 - 1107
  作者：Singh、Sharma、Malik、Kumar

  DOI：——

  日期：——
• Synthesis and biological evaluation of diamide derivatives of (S)-BINOL and biphenyl as potential anti-inflammatory/anti-arthritic agents
  作者：Raj Rajadurai、Ramar Padmanabhan、Sarkkarai Ananthan

  DOI：10.1007/s00044-012-0410-6

  日期：2013.9

  A series of (S)-BINOL and biphenyl based diamides have been synthesized and characterized from analytic and spectral data. Anti-arthritic activity was studied by inhibition of protein denaturation method (Bovine serum albumin). All the diamides exhibit excellent anti-arthritic activity. Anti-inflammatory activity of the diamides synthesized was investigated using human red blood cells membrane stabilization method, and some of the diamides exhibit good anti-inflammatory activity.
• Synthesis, Characterization, and Phytotoxic and Antifungal Activities of Biphenyl Derivatives
  作者：Q. Ali、M. Irshad、A. Asghar

  DOI：10.1134/s1070363218100249

  日期：2018.10

  Three series of biphenyl derivatives are synthesized, characterized and evaluated for Lemna minor phytotoxicity and antifungal activity. The synthetic biphenyl analogues 2c and 6c demonstrate significant activity, while compounds 4b and 6b demonstrate high activity. The compounds 2c and 6c can be considered as biaryl-based potential phytotoxic agents. According to in vitro antifungal bioassay the compounds

  合成，表征和评估了三个系列的联苯衍生物的Lemna次要植物毒性和抗真菌活性。合成的联苯类似物2c和6c表现出显着的活性，而化合物4b和6b表现出高活性。化合物2c和6c可以被认为是基于联芳基的潜在植物毒性剂。根据体外抗真菌生物测定，化合物2b，2e和6b表现出中等活性。