Ethyl 6-[(benzhydrylideneamino)oxymethyl]pyridine-3-carboxylate | 800371-89-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl 6-[(benzhydrylideneamino)oxymethyl]pyridine-3-carboxylate
• CAS: 800371-89-5
• 化学式: C₂₂H₂₀N₂O₃
• 分子量: 360.412
• InChiKey: XGGCVCDDBVVXRD-UHFFFAOYSA-N

物化性质

• 沸点：
  503.3±60.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  60.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Ethyl 6-[(benzhydrylideneamino)oxymethyl]pyridine-3-carboxylate 在 sodium hydroxide 、 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Synthesis and GABA uptake inhibitory properties of 6-aryl iminoxymethyl substituted nipecotic acids

  摘要：

  Nipecotic acid derivatives bearing an aryl iminoxymethyl side chain at the position 6 were synthesised and tested for their GABA uptake inhibitory properties. Contrarily to the N-substituted derivatives 2, 3 the introduction of the oxime function in the side chain of analogues of the active nipecotic derivative 4 does neither increase, nor maintain the activity. (C) 2004 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.07.003
• 作为产物：
  描述：

  2,5-吡啶二甲酸二乙酯 在 四氯化碳 、 sodium tetrahydroborate 、 三丁基膦 、 potassium carbonate 、 calcium chloride 作用下， 以 乙腈 为溶剂， 反应 3.25h， 生成 Ethyl 6-[(benzhydrylideneamino)oxymethyl]pyridine-3-carboxylate
  参考文献：
  名称：

  Synthesis and GABA uptake inhibitory properties of 6-aryl iminoxymethyl substituted nipecotic acids

  摘要：

  Nipecotic acid derivatives bearing an aryl iminoxymethyl side chain at the position 6 were synthesised and tested for their GABA uptake inhibitory properties. Contrarily to the N-substituted derivatives 2, 3 the introduction of the oxime function in the side chain of analogues of the active nipecotic derivative 4 does neither increase, nor maintain the activity. (C) 2004 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2004.07.003

文献信息

• Synthesis and GABA uptake inhibitory properties of 6-aryl iminoxymethyl substituted nipecotic acids
  作者：Victor N'Goka、Tine B. Stenbøl、Povl Krogsgaard-Larsen、Gilbert Schlewer

  DOI：10.1016/j.ejmech.2004.07.003

  日期：2004.10

  Nipecotic acid derivatives bearing an aryl iminoxymethyl side chain at the position 6 were synthesised and tested for their GABA uptake inhibitory properties. Contrarily to the N-substituted derivatives 2, 3 the introduction of the oxime function in the side chain of analogues of the active nipecotic derivative 4 does neither increase, nor maintain the activity. (C) 2004 Elsevier SAS. All rights reserved.