Kalium-2-methyl-n-butyrat | 19455-22-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Kalium-2-methyl-n-butyrat
• 英文别名: Potassium;2-methylbutanoate
• CAS: 19455-22-2
• 化学式: C₅H₉O₂*K
• 分子量: 140.224
• InChiKey: VCFOFCPAHBIEHH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.21
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-甲基邻苯二甲酰亚胺 、 Kalium-2-methyl-n-butyrat 以 水 、 丙酮 为溶剂， 反应 1.5h， 以89%的产率得到3-sec-butyl-3-hydroxy-2-methyl-2,3-dihydroisoindol-1-one
  参考文献：
  名称：

  The Photodecarboxylative Addition of Carboxylates to Phthalimides: Scope and Limitations

  摘要：

  Intermolecular photoinduced decarboxylative additions of a series of alkylcarboxylates to N-substituted phthalimides gave the corresponding hydroxy-plithalimidines in moderate to high yields of 39-89%. The potassium salt of 1-adamantanecarboxylic acid predominately underwent simple decarboxylation when irradiated in the presence of N-methylphthalimide. In case of phthalimides carrying suitable leaving groups within the N-side chain, decarboxylation, retro-Aldol cleavage or decarbonylation preceded the intermolecular addition step.

  DOI：

  10.3987/com-02-s77

文献信息

• DE2134173
  申请人：——

  公开号：——

  公开（公告）日：——
• SCHATOWITZ, BERT;GERCKEN, GUNTHER, J. CHROMATOGR., 409,(1987) 43-54
  作者：SCHATOWITZ, BERT、GERCKEN, GUNTHER

  DOI：——

  日期：——
• The Photodecarboxylative Addition of Carboxylates to Phthalimides: Scope and Limitations
  作者：Michael Oelgemöller、Peter Cygon、Johann Lex、Axel G. Griesbeck

  DOI：10.3987/com-02-s77

  日期：——

  Intermolecular photoinduced decarboxylative additions of a series of alkylcarboxylates to N-substituted phthalimides gave the corresponding hydroxy-plithalimidines in moderate to high yields of 39-89%. The potassium salt of 1-adamantanecarboxylic acid predominately underwent simple decarboxylation when irradiated in the presence of N-methylphthalimide. In case of phthalimides carrying suitable leaving groups within the N-side chain, decarboxylation, retro-Aldol cleavage or decarbonylation preceded the intermolecular addition step.