2-甲基-3a,4,7,7alpha-四氢异吲哚-1,3-二酮 | 2021-21-8

• 物质功能分类: 医药中间体
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 中文名称: 2-甲基-3a,4,7,7alpha-四氢异吲哚-1,3-二酮
• 中文别名: N-甲基1,2,3,6-四氢邻苯二甲酰亚胺
• 英文名称: N-Methyl-Δ⁴-tetrahydrophthalimid
• 英文别名: 1,2,3,6-Tetrahydro-N-methylphthalimide；2-methyl-3a,4,7,7a-tetrahydroisoindole-1,3-dione
• CAS: 2021-21-8
• 化学式: C₉H₁₁NO₂
• mdl: MFCD01735127
• 分子量: 165.192
• InChiKey: UAFTWHXBZBAYKV-UHFFFAOYSA-N

物化性质

• 沸点：
  293.03°C (rough estimate)
• 密度：
  1.1603 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.555
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2925190090

反应信息

• 作为反应物：
  描述：

  2-甲基-3a,4,7,7alpha-四氢异吲哚-1,3-二酮 在 palladium (II) trifluoroacetate 、 sodium anthraquinone-2-sulfonate 、 氧气 、 magnesium sulfate 作用下， 以 氯苯 为溶剂， 110.0 ℃ 、101.33 kPa 条件下， 反应 24.0h， 以94%的产率得到N-甲基邻苯二甲酰亚胺
  参考文献：
  名称：

  钯催化环己烯有氧氧化脱氢生成取代芳烃衍生物

  摘要：

  钯(II)催化剂体系已被确定用于取代环己烯有氧脱氢成相应的芳烃衍生物。使用蒽醌-2-磺酸钠（AMS）作为助催化剂可提高产品收率。反应中可以耐受多种官能团，并描述了该方法的范围和局限性。展示了环己烯催化脱氢生成基于邻苯二甲酰亚胺的 TRPA1 活性调节剂的有效途径。

  DOI：

  10.1021/ja512770u
• 作为产物：
  描述：

  甲胺 、 四氢化邻苯二甲酸酐 生成 2-甲基-3a,4,7,7alpha-四氢异吲哚-1,3-二酮
  参考文献：
  名称：

  Photochemistry of aliphatic imides. Synthesis of azetidine-2,4-diones via photochemical isomerization of succinimides and N-formyl-N-methyl .alpha.,.beta.-unsaturated amides

  摘要：

  DOI：

  10.1021/jo00314a006

文献信息

• Recyclable cobalt(0) nanoparticle catalysts for hydrogenations
  作者：Philipp Büschelberger、Efrain Reyes-Rodriguez、Christian Schöttle、Jens Treptow、Claus Feldmann、Axel Jacobi von Wangelin、Robert Wolf

  DOI：10.1039/c8cy00595h

  日期：——

  The search for new hydrogenation catalysts that replace noble metals is largely driven by sustainability concerns and the distinct mechanistic features of 3d transition metals. Several combinations of cobalt precursors and specific ligands in the presence of reductants or under high-thermal conditions were reported to provide active hydrogenation catalysts. This study reports a new method of preparation

  寻找替代贵金属的新型加氢催化剂的主要原因是对可持续性的关注以及3d过渡金属的独特机械特性。据报道，在还原剂存在下或在高温条件下，钴前体和特定配体的几种组合可提供活性加氢催化剂。这项研究报告了一种在不存在配体或表面活性剂的情况下通过还原商业CoCl 2制备小的单分散Co（0）纳米颗粒（3-4 nm）的新方法。在烯烃，炔烃，亚胺和杂芳烃（2–20 bar H 2）的氢化中观察到高催化活性。磁性使催化剂分离和多次回收成为可能。
• Solvent-Free Diels–Alder Reaction in a Closed Batch System
  作者：Daolai Sun、Fumiya Sato、Yasuhiro Yamada、Satoshi Sato

  DOI：10.1246/bcsj.20120247

  日期：2013.2.15

  Solvent-free Diels–Alder reactions were carried out by heating a mixture of a volatile diene, such as 1,3-butadiene, isoprene, or 2,3-dimethyl-1,3-butadiene, and a dienophile, such as methyl vinyl ketone, methyl acrylate, or maleic anhydride, in a closed batch reactor. High yields of Diels–Alder products were obtained without using solvents and catalysts within a short reaction time in most of the reactions. In particular, several reactions of dienophiles with 1,3-butadiene, which is known as a diene with low reactivity because of its gaseous form, also proceeded with high yields of Diels–Alder products in the closed batch reactor under conditions pressured by the reactant vapor. Solvent-free reactions provided high yields compared to reactions in solvent since the reaction heat directly resulted in increasing the reaction temperature and pressure. Energy in the exothermic reaction was used effectively in the closed batch system under solvent-free conditions.

  无溶剂的Diels-Alder反应是在一个封闭的批式反应器中，通过加热混合挥发性的二烯烃（如1,3-丁二烯、异戊二烯或2,3-二甲基-1,3-丁二烯）与二烯亲电试剂（如甲基乙烯酮、甲基丙烯酸酯或马来酸酐）而进行的。大多数反应在短时间内在不使用溶剂和催化剂的情况下获得了高产率的Diels-Alder产物。特别是，一些公认由于其气态形式而反应活性较低的1,3-丁二烯与二烯亲电试剂的反应，在封闭批式反应器中，在反应物蒸气压力条件下，也以高产率进行了Diels-Alder产物生成。与溶剂中的反应相比，无溶剂反应提供了更高的产率，因为反应热直接导致了反应温度和压力的升高。在无溶剂条件下，封闭批式系统中有效地利用了放热反应的能量。
• NOVEL EPOXY COMPOUNDS AND PROCESS FOR THEIR PRODUCTION
  申请人：Sasaki Nobutoshi

  公开号：US20090182110A1

  公开（公告）日：2009-07-16

  Novel epoxy compounds represented by the general formula: (wherein R 1 and R 2 each represent hydrogen, a C1-6 alkyl group or a C1-4 trialkylsilyl group, each R 3 may be the same or different and each independently represents hydrogen, alkyl, aryl, aralkyl, alkenyl or fluoroalkyl, and n is 0 or a positive integer), and the general formula: (wherein R 3 represents the same groups specified above, R 4 represents hydrogen, a C1-6 alkyl group or a C1-4 trialkylsilyl group, and n is 0 or a positive integer), and a process for their production.

  新型环氧化合物的通式为：（其中R1和R2分别表示氢、C1-6烷基或C1-4三烷基硅基团，每个R3可以相同或不同，且分别独立地表示氢、烷基、芳基、芳基烷基、烯基或氟烷基，n为0或正整数），以及通式为：（其中R3表示上述相同的基团，R4表示氢、C1-6烷基或C1-4三烷基硅基团，n为0或正整数），以及它们的制备方法。
• NEW PHENYLALANINE DERIVATIVES
  申请人：SUZUKI Nobuyasu

  公开号：US20090048236A1

  公开（公告）日：2009-02-19

  Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the α4 integrins and, therefore, are usable as therapeutic agents or preventive agents for diseases in which α4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.

  特定的苯丙氨酸衍生物或其药学上可接受的盐具有对α4整合素的拮抗作用，因此可用作治疗剂或预防剂，用于α4整合素依赖性黏附过程参与病理的疾病，如炎症性疾病、类风湿性关节炎、炎症性肠病、系统性红斑狼疮、多发性硬化症、干燥综合症、哮喘、银屑病、过敏、糖尿病、心血管疾病、动脉硬化、再狭窄、肿瘤增殖、肿瘤转移和移植排斥。
• THERMOSETTING COMPOSITION AND PRINTED CIRCUIT BOARD USING THE SAME
  申请人：JUNG Myung Sup

  公开号：US20100124037A1

  公开（公告）日：2010-05-20

  A thermosetting composition including an organic solvent, a liquid crystalline thermoset oligomer, and either a crosslinking agent or an epoxy resin or both is disclosed. A printed circuit board which includes the thermosetting composition is also disclosed. The printed circuit board is produced by impregnating the thermosetting composition into a reinforcing material.

  本发明公开了一种热固性组合物，包括有机溶剂、液晶热固性低聚物，以及交联剂或环氧树脂或两者都有。本发明还公开了一种包括该热固性组合物的印刷电路板。该印刷电路板是通过将该热固性组合物浸渍到增强材料中制造的。