(4-(2-(dimethylamino)ethoxy)phenyl)(4-methoxyphenyl)methanone | 1226012-35-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-(2-(dimethylamino)ethoxy)phenyl)(4-methoxyphenyl)methanone
• 英文别名: [4-[2-(dimethylamino)ethoxy]phenyl]-(4-methoxyphenyl)methanone
• CAS: 1226012-35-6
• 化学式: C₁₈H₂₁NO₃
• 分子量: 299.37
• InChiKey: DBFMUQYGJOUUEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.87
• 重原子数：
  22.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  38.77
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (4-(2-(dimethylamino)ethoxy)phenyl)(4-methoxyphenyl)methanone 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以80%的产率得到2-(4-(hydrazono(4-methoxyphenyl)methyl)-phenoxy)-N,N-dimethyl-ethanamine
  参考文献：
  名称：

  Synthesis on novel Tamoxifen derivatives

  摘要：

  The design and synthesis of derivatives of 4-hydroxy-Tamoxifen as potential antagonists of the nuclear receptor LRH-1 are described. Stereoselective McMurry coupling was used to generate the desired internal alkene and a novel method for the synthesis of tetrasubstituted cyclopropane analogues was also developed. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.08.089
• 作为产物：
  描述：

  (4-羟基苯基)-(4-甲氧基苯基)甲酮 、 二甲氨基氯乙烷盐酸 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 以62%的产率得到(4-(2-(dimethylamino)ethoxy)phenyl)(4-methoxyphenyl)methanone
  参考文献：
  名称：

  Synthesis on novel Tamoxifen derivatives

  摘要：

  The design and synthesis of derivatives of 4-hydroxy-Tamoxifen as potential antagonists of the nuclear receptor LRH-1 are described. Stereoselective McMurry coupling was used to generate the desired internal alkene and a novel method for the synthesis of tetrasubstituted cyclopropane analogues was also developed. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.08.089

文献信息

• Synthesis on novel Tamoxifen derivatives
  作者：Jullien Rey、Haipeng Hu、James P. Snyder、Anthony G.M. Barrett

  DOI：10.1016/j.tet.2012.08.089

  日期：2012.11

  The design and synthesis of derivatives of 4-hydroxy-Tamoxifen as potential antagonists of the nuclear receptor LRH-1 are described. Stereoselective McMurry coupling was used to generate the desired internal alkene and a novel method for the synthesis of tetrasubstituted cyclopropane analogues was also developed. (C) 2012 Elsevier Ltd. All rights reserved.