Nickel complexes supported by quinoline-based ligands: synthesis, characterization and catalysis in the cross-coupling of arylzinc reagents and aryl chlorides or aryltrimethylammonium salts
Transition-Metal-Free Cross-Coupling of Aryl and Heteroaryl Thiols with Arylzinc Reagents
作者:Bo Yang、Zhong-Xia Wang
DOI:10.1021/acs.orglett.7b03145
日期:2017.11.17
Cross-coupling of (hetero)arylthiols with arylzinc reagents via C–S cleavage was performed under transition-metal-free conditions. The reaction displays a wide scope of substrates and high functional-group tolerance. Electron-rich and -deficient (hetero)arylthiols and arylzinc reagents can be employed in this transformation. Mg2+ and Li+ ions were demonstrated to facilitate the reaction.
[Pd(Cl)2{P(NC5H10)(C6H11)2}2]-A Highly Effective and Extremely Versatile Palladium-Based Negishi Catalyst that Efficiently and Reliably Operates at Low Catalyst Loadings
作者:Jeanne L. Bolliger、Christian M. Frech
DOI:10.1002/chem.201001201
日期:——
electronically activated, non‐activated, deactivated, stericallyhindered, heterocyclic, and functionalized aryl bromides with various (also heterocyclic) arylzinc reagents, typically within a few minutes at 100 °C in the presence of just 0.01 mol % of catalyst. Aryl bromides containing nitro, nitrile, ether, ester, hydroxy, carbonyl, and carboxyl groups, as well as acetals, lactones, amides, anilines,
[Pd(Cl)2 P(NC 5 H 10)(C 6 H 11)2 } 2 ](1)已通过使市售的[Pd(cod)(Cl)2 ]反应定量制备。室温下在几分钟内在N 2中与易于制备的1-(二环己基膦酰基)哌啶在甲苯中的环辛二烯)。综合大楼1已被证明是极佳的Negishi催化剂,能够将各种电子活化,非活化,失活,空间受阻,杂环和官能化的芳基溴化物与各种(也是杂环的)芳基锌试剂定量偶联,通常在几分钟内即可完成。 100°C,仅存在0.01 mol%的催化剂。含有硝基,腈,醚,酯,羟基,羰基和羧基的芳基溴化物,以及缩醛,内酯,酰胺,苯胺,烯烃,羧酸,乙酸,吡啶和嘧啶已被成功用作偶联伙伴。此外,在两个反应伙伴中都可以容忍电子和空间变化。实验观察强烈表明分子机制是有效的。
Boron-Catalyzed Aromatic C–H Bond Silylation with Hydrosilanes
作者:Yuanhong Ma、Baoli Wang、Liang Zhang、Zhaomin Hou
DOI:10.1021/jacs.6b01349
日期:2016.3.23
Metal-free catalytic C-H silylation of a series of aromatic compounds such as N,N-disubstituted anilines with various hydrosilanes has been achieved for the first time using commercially available B(C6F5)3 as a catalyst. This protocol features simple and neutral reaction conditions, high regioselectivity, wide substrate scope (up to 40 examples), Si-Cl bond compatibility, and no requirement for a hydrogen
Palladium-catalyzed selective synthesis of unsymmetrical biaryls from aryl halides or triflates and organomanganese reagents
作者:Eric Riguet、Mouâd Alami、Gérard Cahiez
DOI:10.1016/s0040-4039(97)00940-4
日期:1997.6
Various functionalized unsymmetrical biaryls can be prepared in good to excellent isolated yields by palladium-catalyzed coupling reaction of aryl manganese chloride with aryl iodides, bromides or triflates. The reaction takes place rapidly and cleanly under mild conditions by using only 1% of palladium complexes.