1-chloro-4-(cyclopentylidenemethyl)benzene | 119395-63-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-chloro-4-(cyclopentylidenemethyl)benzene
• CAS: 119395-63-0
• 化学式: C₁₂H₁₃Cl
• 分子量: 192.688
• InChiKey: GGWMGRQYGLALIU-UHFFFAOYSA-N

物化性质

• 沸点：
  294.4±9.0 °C(Predicted)
• 密度：
  1.143±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  在 二苯基硅烷 、 联硼酸频那醇酯 、 sodium iodide 、 copper(l) chloride 、 sodium hydroxide 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 8.0h， 生成 1-chloro-4-(cyclopentylidenemethyl)benzene
  参考文献：
  名称：

  Switchable Synthetic Strategy toward Trisubstituted and Tetrasubstituted Exocyclic Alkenes

  摘要：

  An efficient and facile method for the construction of tri- or tetrasubstituted exocyclic alkenes is achieved via a Cu(I)-catalytic system. This protocol exhibits mild conditions, low-cost catalyst, good functional group tolerance, and good yields. The selectivity toward tri- or tetrasubstituted alkenes can be delicately controlled by adjustment of base and solvent. A preliminary mechanism study manifested that the reaction undergoes a radical process, where B(2)pin(2) plays an indispensable role.

  DOI：

  10.1021/acs.orglett.8b02801

文献信息

• Alkene homologation <i>via</i> visible light promoted hydrophosphination using triphenylphosphonium triflate
  作者：Vitalij V. Levin、Alexander D. Dilman

  DOI：10.1039/d0cc07025d

  日期：——

  A hydrophosphination reaction of alkenes with triphenylphosphonium triflate under photocatalytic conditions is described. The reaction is promoted by naphthalene-fused N-acylbenzimidazole and is believed to proceed through intermediate formation of a phosphinyl radical cation. The resulting phosphonium salts are directly involved in the Wittig reaction leading to homologated alkenes.

  描述了在光催化条件下烯烃与三氟甲磺酸三苯基phosph的氢磷酸化反应。该反应由萘稠合的N-酰基苯并咪唑促进，并且据信通过膦酰基自由基阳离子的中间形成而进行。生成的phospho盐直接参与Wittig反应，从而生成同构的烯烃。
• Aryltriolborates as Air- and Water-Stable Bases for Wittig Olefination
  作者：Wenhua Huang、Shuang-Hong Zhao、Ning Xu

  DOI：10.1055/s-0034-1378919

  日期：——

  1-tris(hydroxymethyl)ethane, and aqueous tetrabutylammonium hydroxide. The aryltriolborates can be used as bases in Wittig reactions of aromatic aldehydes with all three types of phosphorus ylides: stabilized and semistabilized ylides can be generated at room temperature, and nonstabilized ylides at 120 °C (bath temperature). Tetrabutylammonium aryltriolborates have been synthesized in 37–66% yield by a one-pot

  摘要 通过一锅法从芳基硼酸，1,1,1-三（羟甲基）乙烷和四丁基氢氧化铵水溶液一锅法合成了芳基三硼酸四丁基铵硼酸酯。三芳基硼酸酯可以用作芳族醛与所有三种类型的磷酰化物的Wittig反应的碱：可以在室温下生成稳定和半稳定的化物，并在120°C（浴温）下生成不稳定的化物。 通过一锅法从芳基硼酸，1,1,1-三（羟甲基）乙烷和四丁基氢氧化铵水溶液一锅法合成了芳基三硼酸四丁基铵硼酸酯。三芳基硼酸酯可以用作芳族醛与所有三种类型的磷酰化物的Wittig反应的碱：可以在室温下生成稳定和半稳定的化物，并在120°C（浴温）下生成不稳定的化物。
• Consecutive visible-light photoredox decarboxylative couplings of adipic acid active esters with alkynyl sulfones leading to cyclic compounds
  作者：Jingjing Li、Hua Tian、Min Jiang、Haijun Yang、Yufen Zhao、Hua Fu

  DOI：10.1039/c6cc04386k

  日期：——

  active esters (bis(1,3-dioxoisoindolin-2-yl)-substituted hexanedioates) with substituted 1-(2-arylethynylsulfonyl)benzenes have been developed under visible-light photocatalysis. The successive photoredox decarboxylative C-C bond formation...

  在可见光光催化下，己二酸活性酯（双（1，3-二氧代异吲哚啉-2-基）取代的己二酸酯）与取代的1-（2-芳基乙炔基磺酰基）苯的新型高效连续光氧化还原脱羧偶联已得到开发。连续的光氧化还原脱羧CC键的形成...
• Synthesis of Exocyclic Trisubstituted Alkenes <i>via</i> Nickel‐ Catalyzed Kumada‐Type Cross‐Coupling Reaction of <i>gem</i> ‐ Difluoroalkenes with Di‐Grignard Reagents
  作者：Wenpeng Dai、Xuxue Zhang、Juan Zhang、Yingyin Lin、Song Cao

  DOI：10.1002/adsc.201500889

  日期：2016.1.21

  A practical, nickel‐catalyzed Kumada‐type double cross‐coupling reaction of gem‐difluoroalkenes with 1,4‐ or 1,5‐di‐Grignard reagents was developed. The reaction proceeded efficiently at room temperature and a variety of cyclization products, arylmethylenecyclopentanes and arylmethylenecyclohexanes, were obtained in high to excellent yields, respectively.

  开发了一种实用的镍催化的宝石二氟烯烃与1,4或1,5-二格里雅试剂的Kumada型双交叉偶联反应。该反应在室温下有效地进行，并且分别以高至优异的收率获得了各种环化产物，芳基亚甲基环戊烷和芳基亚甲基环己烷。
• GLYCINE TRANSPORTER INHIBITOR
  申请人：TAISHO PHARMACEUTICAL CO., LTD

  公开号：US20160130278A1

  公开（公告）日：2016-05-12

  The present invention provides novel compounds of formula [IA] or pharmaceutically acceptable salts thereof: which are useful in the prevention or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (e.g., generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, acute stress disorder), depression, drug dependence, spasm, tremor, pain, Parkinson's disease, attention deficit hyperactivity disorder, bipolar disorder, eating disorder, or sleep disorders, which is based on the glycine uptake-inhibiting action.

  本发明提供了式[IA]的新化合物或其药用盐：这些化合物在预防或治疗精神分裂症、阿尔茨海默病、认知障碍、痴呆、焦虑障碍（如广泛性焦虑障碍、恐慌障碍、强迫症、社交焦虑障碍、创伤后应激障碍、特定恐惧症、急性应激障碍）、抑郁症、药物依赖、痉挛、震颤、疼痛、帕金森病、注意力缺陷多动障碍、双相情感障碍、进食障碍或睡眠障碍等疾病的治疗中具有用处，其作用基于甘氨酸摄取抑制作用。