3-(dimethylamino)propanamide | 20101-88-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(dimethylamino)propanamide
• 英文别名: 3-(N,N-dimethylamino)propylamide
• CAS: 20101-88-6
• 化学式: C₅H₁₂N₂O
• mdl: MFCD04343934
• 分子量: 116.163
• InChiKey: NIXQLMVKRBUSPF-UHFFFAOYSA-N

物化性质

• 熔点：
  39.8-40.3 °C
• 沸点：
  107-110 °C(Press: 3.5 Torr)
• 密度：
  0.975±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(dimethylamino)propanamide 生成 N,N-二甲基乙二胺
  参考文献：
  名称：

  BADIC, MARIA ELENA;IONESCU, MARIANA;STEFAN, MIHAELA IULIA;HARLES, LUCIAN +

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N-二甲基-1,3-二氨基丙烷 生成 3-(dimethylamino)propanamide
  参考文献：
  名称：

  Cold flow improving fuel additive compound and fuel composition containing same

  摘要：

  在烃类馏分燃料中添加分支链单羧酸酰胺或酯、环氧化物和羧酸的反应产物，以少量有效添加，可提供具有改善冷流动性的燃料组成。

  公开号：

  EP0220892A3

文献信息

• Amides of amphoteric polyene macrolide antibiotics
  申请人：Politechnika Gdanska

  公开号：US04783527A1

  公开（公告）日：1988-11-08

  The invention relates to amides of polyene macrolide antibiotics and their derivatives characterized by the general formula I, ##STR1## where R is the polyene macrolide, R.sub.1 is an alkyl or isoalkyl chain of from one to eighteen carbons, unsubstituted or substituted with a primary or secondary amine; where R.sub.2 is an hydrogen or R.sub.1 or R.sub.1 and R.sub.2 are joined through the nitrogen to form a heterocyclic ring. The method of preparation of these substances according to our invention depends upon the reaction of the polyene macrolide or its derivative in which the carboxylic group is activated; in the environment of an organic solvent or mixture of solvents and in the presence of a substance neutralizing the acid; with a compound containing an amino group; leaving upon completion of the reaction; and precipitation of the product from the reaction mixture, by addition of ethyl ether or a mixture of ethyl ether with hydrocarbons; isolation and purification of the product by means of known methods.

  该发明涉及聚烯烃大环内酰胺类抗生素及其衍生物，其特征在于一般式I，其中R为聚烯烃大环内酰胺，R.sub.1为由一至十八个碳组成的烷基或异烷基链，未取代或取代有一次或二次胺基；其中R.sub.2为氢或R.sub.1，或R.sub.1和R.sub.2通过氮原子连接形成杂环。根据我们的发明，这些物质的制备方法取决于聚烯烃大环内酰胺或其衍生物在羧基被激活的情况下的反应；在有机溶剂或溶剂混合物的环境中，在存在中和酸的物质的情况下，与含氨基团的化合物发生反应；反应完成后，通过加入乙醚或乙醚与烃的混合物使反应混合物中的产物沉淀；通过已知方法分离和纯化产物。
• Anti-inflammatory phthalazinones
  申请人：Pennwalt Corporation

  公开号：US04665181A1

  公开（公告）日：1987-05-12

  A compound useful as anti-inflammatory agents in warm-blooded animals of the formula ##STR1## wherein X is a member of the class of ethylene and ethenyl and is substituted for hydrogen in the sixth or seventh position of the 1(2H)-phthalazinone ring Y is a member of the class of hydrogen and hydroxyl R.sub.1 is a member of the class of hydrogen, alkyl, alkoxy, hydroxyl, halogen, nitro, --NR.sub.3 R.sub.4, --COR.sub.5 and --O--A wherein A is a mineral acid residue which with --O-- forms an ester or the alkali metal salt of said ester, R.sub.2 is a member of the class of hydrogen, alkyl, phenyl, substituted phenyl, heteroaryl, hydroxyalkylene, polyhydroxyalkylene, aminoalkylene, alkylaminoalkylene, and carboxyalkylene, R.sub.3, R.sub.4 are independently from the class of hydrogen, alkyl, aminoalkylene or alkylaminoalkylene, R.sub.5 is a member of the class of OR.sub.3 and ##STR2## for example hydroxyl, methoxyl, 2-dimethylaminoethoxyl or 2-dimethylaminoethylamino, and wherein by alkyl and alkylene is meant respectively a mono- or divalent saturated aliphatic radical containing up to about eight carbon atoms, wherein the nitrogen of the alkylamino or alkylaminoalkylene may form a heterocycle with the alkyl or alkylene groups, wherein substituted phenyl may be substituted by, for example, alkyl, hydroxyl, alkoxy, halogen, nitro or amino, wherein heteroaryl may be, for example, 2-pyridyl.

  一种化合物可用作温血动物的抗炎剂，其化学式为##STR1##其中X是乙烯和乙烯基类的成员，并取代1(2H)-邻苯二酮环的第六或第七位置的氢原子；Y是氢和羟基类的成员；R.sub.1是氢、烷基、烷氧基、羟基、卤素、硝基、--NR.sub.3 R.sub.4、--COR.sub.5和--O--A类的成员，其中A是与--O--形成酯或所述酯的碱金属盐的矿酸残基，R.sub.2是氢、烷基、苯基、取代苯基、杂环烯基、羟基烷基、多羟基烷基、氨基烷基、烷基氨基烷基和羧基烷基类的成员，R.sub.3、R.sub.4独立地来自氢、烷基、氨基烷基或烷基氨基烷基类，R.sub.5是OR.sub.3和##STR2##类的成员，例如羟基、甲氧基、2-二甲氨基乙氧基或2-二甲基氨基乙基氨基，其中烷基和烷基烯分别指含有最多约八个碳原子的单价或二价饱和脂肪基团，其中烷基氨基或烷基氨基烷基的氮原子可以与烷基或烷基烯基形成杂环，取代苯基可以通过烷基、羟基、烷氧基、卤素、硝基或氨基等取代，取代杂环烯基可以是例如2-吡啶基。
• The Preparation and Stabilities of Some β-Dialkylaminopropionamides
  作者：John G. Erickson

  DOI：10.1021/ja01144a509

  日期：1952.12
• Pd(quinoline-8-carboxylate)₂ as a Low-Priced, Phosphine-Free Catalyst for Heck and Suzuki Reactions
  作者：Xin Cui、Juan Li、Zhi-Ping Zhang、Yao Fu、Lei Liu、Qing-Xiang Guo

  DOI：10.1021/jo701783k

  日期：2007.11.1

  [Graphics]N,O-Bidentate compounds were systematically evaluated as phosphine-free ligands for Pd-catalyzed C-C bond-formation reactions through kinetic measurements. Pd(quinoline-8-carboxylate)(2) was identified as one of the most efficient, yet still low-priced, phosphine-free catalysts for Heck as well as Suzuki reactions of unactivated aryl bromides with high turnover numbers up to ca. 10,000.
• [EN] STORAGE STABLE SOLUTIONS OF OPTICAL BRIGHTENING AGENTS<br/>[FR] SOLUTIONS D'AZURANTS OPTIQUES PRÉSENTANT UNE BONNE STABILITÉ AU STOCKAGE
  申请人：DEEPAK NITRITE LTD

  公开号：WO2016142955A4

  公开（公告）日：2016-11-24