2-(2,3-二氢-苯并[1,4]二噁英-2-基)-乙胺 | 87086-36-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 中文名称: 2-(2,3-二氢-苯并[1,4]二噁英-2-基)-乙胺
• 中文别名: 2,6-二氟苯胺
• 英文名称: 2-(2-aminoethyl)-2,3-dihydro-1,4-benzodioxin
• 英文别名: 2-(2,3-dihydrobenzo[1,4]dioxin-2-yl)ethylamine；2-<2-Amino-aethyl>-1,4-benzodioxan；2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-aethylamin；2-(2-aminoethyl)-benzo-1,4-dioxan；2-(2,3-Dihydro-benzo[1,4]dioxin-2-YL)-ethylamine；2-(2,3-dihydro-1,4-benzodioxin-3-yl)ethanamine
• CAS: 87086-36-0
• 化学式: C₁₀H₁₃NO₂
• mdl: MFCD01659461
• 分子量: 179.219
• InChiKey: BIDRHBDWACXXJK-UHFFFAOYSA-N

物化性质

• 沸点：
  85-86 °C(Press: 0.03 Torr)
• 密度：
  1.122±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  2-(2,3-二氢-苯并[1,4]二噁英-2-基)-乙胺 在 磺酰胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 生成 N-(2-(2,3-dihydrobenzo[1,4]dioxin-2-yl)ethyl)sulfamide
  参考文献：
  名称：

  Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders

  摘要：

  本发明涉及新型磺胺酰胺和磺酸酯衍生物，包括含有它们的药物组合物以及它们在治疗癫痫和相关疾病中的用途。

  公开号：

  US20050282887A1
• 作为产物：
  描述：

  1,4-苯并二氧六环-2-甲酸乙酯 在 palladium on activated charcoal 盐酸 、 N-溴代丁二酰亚胺(NBS) 、 lithium aluminium tetrahydride 、 氢气 、 三苯基膦 作用下， 以 四氢呋喃 、 甲醇 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 20.0~65.0 ℃ 、101.33 kPa 条件下， 反应 78.5h， 生成 2-(2,3-二氢-苯并[1,4]二噁英-2-基)-乙胺
  参考文献：
  名称：

  Design and synthesis of substituted compounds containing the 1,4-benzodioxin subunit. New potential calcium antagonists

  摘要：

  New compounds possessing 1,4-benzodioxin or its saturated analogous heterocyclic system were synthesized and tested for calcium antagonist activity. Biological differences were seen between the different modifications applied. These compounds have been shown to be representative of a novel series of calcium channel antagonists. (C) 2000 editions scientifiques et medicates Elsevier SAS.

  DOI：

  10.1016/s0223-5234(00)00164-1

文献信息

• [EN] SULFAMATE AND SULFAMIDE DERIVATIVES FOR THE TREATMENT OF EPILEPSY AND RELATED DISORDERS<br/>[FR] DÉRIVÉS DE SULFAMATE ET DE SULFAMIDE POUR LE TRAITEMENT DE L'ÉPILEPSIE ET DE TROUBLES APPARENTÉS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2006007435A1

  公开（公告）日：2006-01-19

  The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical composlons containing them and their use in the treatment of epilepsy and related disorders.

  本发明涉及新型磺胺酰胺和磺酸酯衍生物，包含它们的药物组合物以及它们在治疗癫痫和相关疾病中的用途。
• USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR LOWERING LIPIDS AND LOWERING BLOOD GLUCOSE LEVELS
  申请人：Smith-Swintosky L. Virginia

  公开号：US20070155821A1

  公开（公告）日：2007-07-05

  The present invention is a method for the glucose related disorders and lipid related disorders comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) or formula (II) as herein defined. The present invention is further directed to methods of treatment comprising co-therapy with an anti-diabetic agent, and anti-lipid agent and/or an anti-obesity agent.

  本发明涉及一种治疗葡萄糖相关疾病和脂质相关疾病的方法，包括向需要的受试者施用一种或多种新型苯并杂环磺胺衍生物的治疗有效量，其化学结构如公式(I)或公式(II)所定义。本发明还涉及治疗方法，包括与抗糖尿病药物、抗脂质药物和/或抗肥胖药物联合治疗。
• USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF DEPRESSION
  申请人：Smith-Swintosky L. Virginia

  公开号：US20070155827A1

  公开（公告）日：2007-07-05

  The present invention is a method for the treatment of depression comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as herein defined. The present invention is directed to a method for the treatment of depression, which includes mono-therapy and alternatively, co-therapy with at least one antidepressant.

  本发明涉及一种治疗抑郁症的方法，包括向需要的受试者施用一种或多种新型苯并杂环磺酰胺衍生物的治疗有效量，其化学式为(I)和(II)。本发明涉及一种治疗抑郁症的方法，包括单独治疗和/或与至少一种抗抑郁药物联合治疗。
• Hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds
  申请人：Ciba-Geigy Corporation

  公开号：US04957928A1

  公开（公告）日：1990-09-18

  The invention relates to novel hydrogenated 1-benzooxacycloalkylpyridinecarboxylic acid compounds of formula ##STR1## in which the variable R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, alk, X, Z, m, n and p, the dotted line and the substituents of the ring A have the meanings indicated in the specification and in the claims, and to their tautomers and/or salts. These compounds can be used as pharmaceutical active ingredients and can be prepared in a manner known per se.

  该发明涉及一种新型的氢化1-苯氧基环氧烷基吡啶羧酸化合物，其化学结构如下：在该结构中，变量R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, alk, X, Z, m, n和p，虚线和环A的取代基具有规范和索赔中指示的含义，以及它们的互变异构体和/或盐。这些化合物可以用作药用活性成分，并且可以按照已知的方法制备。
• USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN
  申请人：Smith-Swintosky L. Virginia

  公开号：US20070155822A1

  公开（公告）日：2007-07-05

  The present invention is a method for the treatment of pain comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as described herein. The present invention is further directed to methods for the treatment of pain comprising co-therapy with analgesic agent(s) and a compound of formula (I) or formula (II) as described herein.

  本发明涉及一种用于治疗疼痛的方法，包括向需要的受试者施用一种或多种根据本文描述的新型苯并杂环磺酰胺衍生物的治疗有效量。本发明还涉及一种治疗疼痛的方法，包括与镇痛剂联合治疗，并根据本文描述的化合物的公式(I)或公式(II)。