5-(3,4-diamino-tetrahydro-thiophen-2-yl)-pentanoic acid | 3737-34-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-(3,4-diamino-tetrahydro-thiophen-2-yl)-pentanoic acid
• 英文别名: Biotin-diamino-carbonsaeure；5-(3-amino-4-azaniumylthiolan-2-yl)pentanoate
• CAS: 3737-34-6
• 化学式: C₉H₁₈N₂O₂S
• mdl: MFCD01115291
• 分子量: 218.32
• InChiKey: JKNCSZDPWAVQAI-UHFFFAOYSA-N

物化性质

• 沸点：
  409.8±45.0 °C(Predicted)
• 密度：
  1.179±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(3,4-diamino-tetrahydro-thiophen-2-yl)-pentanoic acid 、 光气-13C 生成 (2'-(13)C)Biotin
  参考文献：
  名称：

  ETZEL, W. A.;BERGER, S., J. LABELL. COMPOUNDS AND RADIOPHARM., 28,(1990) N, C. 977-982

  摘要：

  DOI：
• 作为产物：
  描述：

  5-(3,4-Diamino-tetrahydro-thiophen-2-yl)-pentanoic acid; compound with sulfuric acid 生成 5-(3,4-diamino-tetrahydro-thiophen-2-yl)-pentanoic acid
  参考文献：
  名称：

  ETZEL, W. A.;BERGER, S., J. LABELL. COMPOUNDS AND RADIOPHARM., 28,(1990) N, C. 977-982

  摘要：

  DOI：

文献信息

• [EN] HPLC METHOD FOR DETECTING BIOTIN INTERMEDIATE DIAMINO SUBSTANCE<br/>[FR] PROCÉDÉ DE CLHP PERMETTANT DE DÉTECTER UNE SUBSTANCE DIAMINO INTERMÉDIAIRE DE BIOTINE<br/>[ZH] 一种生物素中间体双氨基物的HPLC检测方法
  申请人：SHANGYU NHU BIO CHEM CO LTD

  公开号：WO2021128665A1

  公开（公告）日：2021-07-01

  一种生物素中间体双氨基物的HPLC检测方法，该检测方法包括如下步骤：用流动相溶解生物素合成过程中的环合反应液后，在以下色谱条件下进行检测：色谱柱为C18-WCX混合柱，检测波长为195-220nm，测试时间为16-20min，流动相为乙腈-磷酸盐缓冲液。该检测方法可以使待测物质双氨基物的出峰时间稳定在10-12min，解决了双氨基物与溶剂峰出峰重合的问题，使得监测更加准确、可靠。
• AOKI, YASUXIKO;SUDZUKI, XIROYUKI;NAKAGOMEH, TAKEHYA
  作者：AOKI, YASUXIKO、SUDZUKI, XIROYUKI、NAKAGOMEH, TAKEHYA

  DOI：——

  日期：——
• JPH06263752A
  申请人：——

  公开号：JPH06263752A

  公开（公告）日：1994-09-20
• DISSOCIATION METHOD AND DISSOCIATION AGENT FOR AVIDIN AND BIOTIN DERIVATIVES
  申请人：Katayose Satoshi

  公开号：US20120171763A1

  公开（公告）日：2012-07-05

  A method for dissociating avidin or streptavidin efficiently from a biotin derivative, thereby making it possible to isolate a target material efficiently under a mild condition in a short period, and a dissociation agent for use thereof, are provided. The method for dissociating avidin or streptavidin from a biotin derivative, includes mixing a combination of avidin or streptavidin with desthiobiotin with a water-soluble polymer to which biotin or a derivative thereof is bound.
• NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF
  申请人：Roche Diagnostics Operations, Inc.

  公开号：US20190309091A1

  公开（公告）日：2019-10-10

  The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.