5-甲基-1-[(4-甲基苯基)甲基]三唑-4-羧酸乙酯 | 1030014-84-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-甲基-1-[(4-甲基苯基)甲基]三唑-4-羧酸乙酯
• 中文别名: 5-甲基-1-（4-甲基苄基）-1H-1,2,3-三唑-4-羧酸乙酯
• 英文名称: ethyl 5-methyl-1-(4-methylbenzyl)-1H-1,2,3-triazole-4-carboxylate
• 英文别名: ethyl 5-methyl-1-[(4-methylphenyl)methyl]triazole-4-carboxylate
• CAS: 1030014-84-6
• 化学式: C₁₄H₁₇N₃O₂
• 分子量: 259.308
• InChiKey: WTHNJWJCZRLSAM-UHFFFAOYSA-N

物化性质

• 熔点：
  132°

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  57
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  5-甲基-1-[(4-甲基苯基)甲基]三唑-4-羧酸乙酯 在 lithium hydroxide monohydrate 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 6.0h， 以78.8%的产率得到5-methyl-1-(4-methylbenzyl)-1H-1,2,3-triazole-4-carboxylic acid
  参考文献：
  名称：

  [EN] SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
  [FR] MODULATEURS SPIROLACTAMES D'UN RÉCEPTEUR NMDA ET LEURS UTILISATIONS

  摘要：

  揭示了在调节NMDA受体活性方面具有增强效力的化合物。这些化合物可用于治疗抑郁症和相关疾病。此外，还披露了口服制剂和其他药学上可接受的化合物给药形式，包括静脉注射制剂。

  公开号：

  WO2014120800A1
• 作为产物：
  描述：

  1-(迭氮基甲基)-4-甲苯 、 乙酰乙酸乙酯 在 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 2.0h， 生成 5-甲基-1-[(4-甲基苯基)甲基]三唑-4-羧酸乙酯
  参考文献：
  名称：

  Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi

  摘要：

  Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, is the most common cause of cardiac-related deaths in endemic regions of Latin America. There is an urgent need for new safer treatments because current standard therapeutic options, benznidazole and nifurtimox, have significant side effects and are only effective in the acute phase of the infection with limited efficacy in the chronic phase. Phenotypic high content screening against the intracellular parasite in infected VERO cells was used to identify a novel hit series of 5-amino-1,2,3-triazole-4-carboxamides (ATC). Optimization of the ATC series gave improvements in potency, aqueous solubility, and metabolic stability, which combined to give significant improvements in oral exposure. Mitigation of a potential Ames and hERG liability ultimately led to two promising compounds, one of which demonstrated significant suppression of parasite burden in a mouse model of Chagas' disease.

  DOI：

  10.1021/acs.jmedchem.7b00463

文献信息

• PYRAZOLE COMPOUNDS AND USE THEREOF
  申请人：Takagi Masaki

  公开号：US20090036450A1

  公开（公告）日：2009-02-05

  The pyrazole compound of the present invention is represented by the following general formula (I). The pyrazole compound of the present invention or a salt thereof or a solvate thereof potently inhibits liver glycogen phosphorylase, and, therefore, is useful as a therapeutic or prophylactic agent for diabetes. wherein each symbol denotes as described in the specifications.

  本发明的吡唑化合物由以下一般式（I）表示。本发明的吡唑化合物或其盐或溶剂化物强力抑制肝糖原磷酸化酶，因此，可用作糖尿病的治疗或预防剂。其中，每个符号如规范中所述。
• SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
  申请人：NAUREX, INC.

  公开号：US20150368254A1

  公开（公告）日：2015-12-24

  Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

  本发明涉及一种具有增强的NMDA受体调节活性的化合物。这样的化合物被考虑用于治疗抑郁症和相关疾病。本发明还揭示了口服制剂和其他药学上可接受的化合物输送形式，包括静脉注射制剂。
• PYRAZOLES AND USE THEREOF AS DRUGS
  申请人：Japan Tobacco Inc.

  公开号：EP2096111A1

  公开（公告）日：2009-09-02

  The pyrazole compound of the present invention is represented by the following general formula (I). The pyrazole compound of present invention or a salt thereof or a solvate thereof potently inhibits liver glycogen phosphorylase, and, therefore, is useful as a therapeutic or prophylactic agent for diabetes. wherein each symbol denotes as described in the specification.

  本发明的吡唑化合物由以下通式（I）表示。本发明的吡唑化合物或其盐或其溶液能有效抑制肝糖原磷酸化酶，因此可用作糖尿病的治疗或预防药物。 其中各符号表示如说明书所述。
• Spiro-lactam NMDA receptor modulators and uses thereof
  申请人：Apytinyx Inc.

  公开号：US10316041B2

  公开（公告）日：2019-06-11

  Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of conditions such as depression and related disorders. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

  所公开的化合物在调节 NMDA 受体活性方面具有更强的效力。此类化合物可用于治疗抑郁症及相关疾病。还公开了这些化合物的口服制剂和其他药学上可接受的给药形式，包括静脉注射制剂。
• US9708335B2
  申请人：——

  公开号：US9708335B2

  公开（公告）日：2017-07-18