2-tert-butyl-6-isopropylphenol | 22791-95-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-tert-butyl-6-isopropylphenol
• 英文别名: propofol；2-t-butyl-6-isopropylphenol；2-Isopropyl-6-t.butyl-phenol；2-Isopropyl-6-t-butylphenol；2-Isopropyl-6-tert-butylphenol；2-tert-butyl-6-propan-2-ylphenol
• CAS: 22791-95-3
• 化学式: C₁₃H₂₀O
• 分子量: 192.301
• InChiKey: LBLLGKZRDSWOJS-UHFFFAOYSA-N

物化性质

• 保留指数：
  1382.7

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-tert-butyl-6-isopropylphenol 在 hydroxide 、 potassium hexacyanoferrate(III) 作用下， 生成 3,3'-Diisopropyl-5,5'-di-tert-butyl-4,4'-diphenochinon
  参考文献：
  名称：

  Petranek,J. et al., Collection of Czechoslovak Chemical Communications, 1970, vol. 35, p. 2571 - 2581

  摘要：

  DOI：
• 作为产物：
  描述：

  2-Isopropyl-6-tert.-butylhydrochinon 在 镍 sodium hydroxide 、 硫酸 作用下， 以 乙醇 、 正己烷 、 苯 为溶剂， 生成 2-tert-butyl-6-isopropylphenol
  参考文献：
  名称：

  Petranek,J.; Pilar,J., Collection of Czechoslovak Chemical Communications, 1970, vol. 35, p. 830 - 837

  摘要：

  DOI：

文献信息

• Method for the preparation of aromatic chloroformates
  申请人：Davis Charles Gary

  公开号：US20060293535A1

  公开（公告）日：2006-12-28

  A method for preparing an aromatic chloroformate comprising, introducing a mixture of at least one aromatic hydroxyl compound, phosgene, at least one solvent, and at least one organic base into a flow reactor to obtain a unidirectionally flowing reaction mixture. The unidirectionally flowing reaction mixture is maintained at a temperature between about 0° C. and about 60° C. to produce a single product stream comprising an aromatic chloroformate.

  一种制备芳香氯甲酸酯的方法包括，将至少一种芳香羟基化合物、光气、至少一种溶剂和至少一种有机碱的混合物引入流动反应器中，以获得单向流动的反应混合物。将单向流动的反应混合物保持在约0°C至约60°C的温度下，以产生包含芳香氯甲酸酯的单一产物流。
• N-pyrazinyl substituted P-aminophenols
  申请人：Otsuka Pharmaceutical Factory, Inc.

  公开号：US04868183A1

  公开（公告）日：1989-09-19

  Disclosed are compounds of the formula ##STR1## wherein: R.sup.1 is a lower alkyl group; R.sup.2 and R.sup.3 are each hydrogen or lower alkyl or R.sup.2 and R.sup.3 taken together may form --(CH.sub.2 (.sub.4)-- or --CH.dbd.CH--CH.dbd.CH--; .alpha. is a 5- or 6-membered heteroaromatic ring group containing 1 to 3 hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur, or a pyrazine-N-oxide ring, pyridazine-N-oxide ring or pyrimidine-N-oxide ring group, wherein each of these heteroaromatic ring groups may optionally have 1 to 3 substituents selected from the group consisting of a lower alkyl, halogen, phenyl, lower alkoxycarbonyl, amino, lower alkoxy and hydroxy-lower alkyl, with the proviso that said 5- or 6-membered heteroaromatic ring group is not thiazolyl, isothiazolyl, pyridyl or 1,3,5-triazinyl group; or salts thereof. These compounds and salts thereof have anti-inflammatory activity and lipoxygenase-inhibitory activity.

  揭示了以下化合物的结构公式：##STR1## 其中：R.sup.1是较低的烷基基团；R.sup.2和R.sup.3分别是氢或较低的烷基或R.sup.2和R.sup.3结合可形成-（CH.sub.2(.sub.4)-或-CH.dbd.CH-CH.dbd.CH-；α是一个含有1至3个异原子（选自氮、氧和硫的群）的5-或6成员杂环芳基环，或者是吡唑啉-N-氧化物环、吡嗪啉-N-氧化物环或嘧啶-N-氧化物环基团，其中这些异杂环芳基环可选择地具有1至3个选自较低烷基、卤素、苯基、较低烷氧羰基、氨基、较低烷氧基和羟基较低烷基的取代基，但前提是所述的5-或6-成员杂环芳基环不是噻唑基、异噻唑基、吡啶基或1,3,5-三嗪基团；或其盐。这些化合物及其盐具有抗炎活性和抑制脂氧合酶活性。
• N-heterocyclo-substituted p-aminophenols
  申请人：Otsuka Pharmaceutical Factory, Inc.

  公开号：US05059598A1

  公开（公告）日：1991-10-22

  Disclosed are compounds of the formula ##STR1## wherein: R.sup.1 is a lower alkyl group; R.sup.2 and R.sup.3 are each hydrogen or lower alkyl or R.sup.2 and R.sup.3 taken together may form --(CH.sub.2).sub.4 -- or --CH.dbd.CH--CH.dbd.CH--; .alpha. is a 5- or 6-membered heretoaromatic ring group containing 1 to 3 hetero-atoms selected from the group consisting of nitrogen, oxygen and sulfur, or a pyrazine-N-oxide ring, pyridazine-N-oxide ring or pyrimidine -N-oxide ring group, wherein each of these heteroaromatic ring groups may optionally have 1 to 3 substituents selected from the group consisting of a lower alkyl halogen, phenyl, lower alkoxycarbonyl, amino, lower alkoxy and hydroxy-lower alkyl, with the proviso that said 5- or 6-membered heteroaromatic ring group is not thiazolyl, isothiazolyl, pyridyl or 1,3,5-triazinyl group; or salts thereof. These compounds and salts thereof have anti-inflammatory activity and lipoxygenase-inhibitory activity.

  本发明涉及一种式为##STR1##的化合物，其中：R.sup.1是较低的烷基基团；R.sup.2和R.sup.3分别是氢或较低的烷基或R.sup.2和R.sup.3结合可形成--（CH.sub.2）.sub.4--或--CH.dbd.CH--CH.dbd.CH--；.alpha.是一个含有1到3个来自氮、氧和硫的杂原子的5-或6成员的杂环芳基环基团，或者是吡唑啉-N-氧化物环、吡嗪-N-氧化物环或嘧啶-N-氧化物环基团，其中这些杂芳基环基团可以选择地具有1到3个来自较低的烷基卤素、苯基、较低的烷氧羰基、氨基、较低的烷氧基和羟基较低的烷基的取代基，但是所述的5-或6成员的杂原子芳基环基团不是噻唑基、异噻唑基、吡啶基或1,3,5-三嗪基团；或其盐。这些化合物及其盐具有抗炎活性和抑制脂氧化酶活性。
• RUBBER COMPOSITION, RUBBER COMPOSITION FOR TIRE SIDE USE, CROSSLINKED RUBBER COMPOSITION AND TIRE
  申请人：Matsushita Junko

  公开号：US20130324660A1

  公开（公告）日：2013-12-05

  The present invention provides a rubber composition that is used for manufacturing a rubber excellent in weather resistance, fracture resistance and crack growth resistance, and that contains a conjugated diene compound/non-conjugated olefin copolymer, a conjugate diene-based polymer and a non-conjugated diene compound/non-conjugated olefin copolymer, a rubber composition for tire side use using the rubber composition for tire sidewall members, a crosslinked rubber composition obtained by crosslinking the rubber composition, and a tire. The rubber composition includes: (A) a conjugated diene compound/non-conjugated olefin copolymer containing a conjugated diene compound-derived unit by at least 40 mol %; (B) a conjugated diene-based polymer; and (C) a non-conjugated diene compound/non-conjugated olefin copolymer containing an ethylene-propylene-diene rubber.

  本发明提供了一种橡胶组合物，用于制造具有耐候性、抗断裂性和裂纹生长抗性的橡胶，并包含共轭二烯化合物/非共轭烯烃共聚物、共轭二烯基聚合物和非共轭二烯化合物/非共轭烯烃共聚物，用于轮胎侧壁成员的轮胎侧壁使用的橡胶组合物，通过交联橡胶组合物获得的交联橡胶组合物和轮胎。该橡胶组合物包括：(A)含有至少40摩尔％共轭二烯化合物衍生单元的共轭二烯化合物/非共轭烯烃共聚物；(B)共轭二烯基聚合物；和(C)含有乙烯-丙烯-二烯基橡胶的非共轭二烯化合物/非共轭烯烃共聚物。
• 3,5-Dialkyl-4-hydroxyphenyl-substituted derivatives
  申请人：The B.F. GOODRICH Company

  公开号：EP0141419A1

  公开（公告）日：1985-05-15

  3,5-dialkyl-4-hydroxyphenyl-substituted amides, acetic acids and acetic acid esters are novel stabilizers for organic materials subject to attack and degradation by heat, oxygen and light, and form useful combinations for this purpose with other hindered phenol stabilizers, hindered amine stabilizers, phosphite stabilizers, and o-hydroxy- benophenone stabilizers.

  3,5-二烷基-4-羟基苯基取代酰胺、乙酸和乙酸酯是一种新型稳定剂，适用于受热、氧和光侵蚀和降解的有机材料，并为此与其他受阻酚稳定剂、受阻胺稳定剂、亚磷酸酯稳定剂和邻羟基苯甲酮稳定剂形成有用的组合。

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