6-hydroxy-4-oxohexanoic acid | 887586-71-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 6-hydroxy-4-oxohexanoic acid
• 英文别名: 5-hydroxymethyl-4-oxopentanoic acid
• CAS: 887586-71-2
• 化学式: C₆H₁₀O₄
• mdl: MFCD19231711
• 分子量: 146.143
• InChiKey: NDTOOPBXVZHXDG-UHFFFAOYSA-N

物化性质

• 沸点：
  348.6±17.0 °C(Predicted)
• 密度：
  1.250±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-hydroxy-4-oxohexanoic acid 生成 2-oxepane-1,5-dione
  参考文献：
  名称：

  Lactone derivative and its manufacturing method

  摘要：

  一种新的内酯衍生物，其化学结构式(I)如下所示。

  公开号：

  US20060058536A1
• 作为产物：
  描述：

  2-Deoxy-D-glucose 在 硫酸 作用下， 以 水 为溶剂， 反应 1.0h， 生成 6-hydroxy-4-oxohexanoic acid
  参考文献：
  名称：

  Lactone derivative and its manufacturing method

  摘要：

  一种新的内酯衍生物，其化学结构式(I)如下所示。

  公开号：

  US20060058536A1

文献信息

• Solubilization and Targeted Delivery of Drugs With Self-Assembling Amphiphilic Polymers
  申请人：Diwan Anil

  公开号：US20100260743A1

  公开（公告）日：2010-10-14

  There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds such as drugs, vitamins, dyes, and imaging agents. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties useful for the targeted delivery of drugs and imaging agents.

  提供的两性可降解共聚物包括具有羟基亲水骨架和作为疏水组分的脂肪族侧链的共聚物。这些聚合物在水性环境中形成纳米级分子聚集体，具有疏水内部，能够溶解不溶于水的有机化合物，如药物、维生素、染料和成像剂。这些聚合物可选择性地具有反应性功能基团，提供与抗体、配体和其他靶向基团的结合点，有助于药物和成像剂的靶向传递。
• SELF-ASSEMBLING AMPHIPHILIC POLYMERS AS ANTI-CANCER AGENTS
  申请人：Diwan Anil R.

  公开号：US20100239659A1

  公开（公告）日：2010-09-23

  The invention provides amphiphilic biocompatible copolymers which have a hydrophilic backbone and pendant hydrophobic groups. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors within which anticancer drugs may be solubilized. The polymers optionally feature attached antibodies, receptor ligands, and other targeting moieties which mediate adherence of the drug-carrying aggregates to targeted cancer cells.

  本发明提供了一种两性亲水的生物相容性共聚物，其具有亲水性骨架和挂链疏水基团。这些聚合物在水性环境中形成纳米级分子聚集体，其中具有疏水性内部，可在其中溶解抗癌药物。这些聚合物可选地具有连接的抗体、受体配体和其他靶向基团，这些基团介导药物携带聚集体与靶向癌细胞的附着。
• 一种丁二酸类化合物的光催化合成方法
  申请人：北京大学

  公开号：CN117486710A

  公开（公告）日：2024-02-02

  本发明公开了一种丁二酸类化合物的光催化合成方法。所述光催化合成方法包括如下步骤：在光催化剂的催化下，糠醛及其衍生物经选择性氧化反应得到丁二酸类化合物；糠醛及其衍生物的结构式如式Ⅰ或式Ⅱ所示，丁二酸类化合物的结构式如式Ⅲ或式Ⅳ所示；光催化剂为金属氧化物负载的无机半导体光催化剂，其中，金属氧化物的负载量为0.1～1％。本发明以糠醛或糠醛衍生物作为原料，在无机半导体光催化剂的存在下进行选择性转化制备丁二酸类化合物，首次实现了在无机半导体光催化剂上催化生物质基糠醛及其衍生物选择性氧化制备丁二酸类化合物；采用的催化剂活性高，产物选择性高，有很好的应用前景。#imgabs0#
• Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures
  作者：Jonathan D. Mortison、Monica Schenone、Jacob A. Myers、Ziyang Zhang、Linfeng Chen、Christie Ciarlo、Eamon Comer、S. Kundhavai Natchiar、Steven A. Carr、Bruno P. Klaholz、Andrew G. Myers

  DOI：10.1016/j.chembiol.2018.09.010

  日期：2018.12

  Apart from their antimicrobial properties, tetracyclines demonstrate clinically validated effects in the amelioration of pathological inflammation and human cancer. Delineation of the target(s) and mechanism(s) responsible for these effects, however, has remained elusive. Here, employing quantitative mass spectrometry-based proteomics, we identified human 80S ribosomes as targets of the tetracyclines Col-3 and doxycycline. We then developed in-cell click selective crosslinking with RNA sequence profiling (icCL-seq) tomap binding sites for these tetracyclines on key human rRNA substructures at nucleotide resolution. Importantly, we found that structurally and phenotypically variant tetracycline analogs could chemically discriminate these rRNA binding sites. We also found that tetracyclines both subtly modify human ribosomal translation and selectively activate the cellular integrated stress response (ISR). Together, the data reveal that targeting of specific rRNA substructures, activation of the ISR, and inhibition of translation are correlated with the anti-proliferative properties of tetracyclines in human cancer cell lines.
• FUNCTIONALIZED CARBOXYLIC ACIDS AND ALCOHOLS BY REVERSE FATTY ACID OXIDATION
  申请人：William Marsh Rice University

  公开号：EP2753689B1

  公开（公告）日：2018-02-14