4-tert-Pentylveratrol | 93308-48-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-tert-Pentylveratrol
• 英文别名: 4-tert.-Amyl-guajacol-methylaether；1,2-Dimethoxy-4-(2-methylbutan-2-yl)benzene
• CAS: 93308-48-6
• 化学式: C₁₃H₂₀O₂
• 分子量: 208.301
• InChiKey: AHFWQVGEQYNXBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲基-2-丁醇 在 sodium hydroxide 、 氢氟酸 、 三氟化硼 作用下， 以 乙醇 为溶剂， 生成 4-tert-Pentylveratrol
  参考文献：
  名称：

  Dat-Xuong,N. et al., Bulletin de la Societe Chimique de France, 1961, p. 1136 - 1140

  摘要：

  DOI：

文献信息

• Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives
  申请人：Altmann Eva

  公开号：US20100063075A1

  公开（公告）日：2010-03-11

  A compound of formula (1): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions which are associated with increased calcium depletion or resorption or in which stimulation of bone formation and calcium fixation in the bone is desirable.

  式（1）的化合物：其中R1、R2、R3和Y的定义如本文所述，或其药学上可接受和可水解酯或酸加合物盐，有助于促进甲状旁腺激素的释放，例如用于预防或治疗与钙丢失或吸收增加有关的骨病或骨形成和钙固定在骨中的刺激是有益的。
• Synthesis of amides and amines from aldehydes or ketones by heterogeneous metal catalysis
  申请人：ORGANOFUEL SWEDEN AB

  公开号：US10308588B2

  公开（公告）日：2019-06-04

  A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.

  本发明公开了一种利用异相金属催化剂和胺供体从醛或酮温和高效合成伯胺和酰胺的方法。在羰基和胺供体组分之间进行最初的异相金属催化反应后，再加入适当的酰化剂组分，从而实现了酰胺的单组分催化合成。结合酶催化，可分别从醛基质和酮基质中以环保方式实现酰胺的单锅共催化合成。该工艺可用于不对称合成，也可用于以香兰素或香草醇为原料，在一次催化下合成辣椒素及其类似物。本发明公开了一种从酮不对称合成光学活性酰胺的共催化还原胺化/动态动力学解析（dkr）中继序列。通过催化还原酰胺化/动力学解析（kr）中继顺序，可生成与起始酮具有相反立体化学结构的相应光学活性酰胺产物和光学活性伯胺产物。
• 6-aryl-7-substituted-3-(1H-pyrazol-5-yl)-7H-[1,2,4]triazolo[3,4-B][1,3,4]thiadiazines as inhibitors of the STAT3 pathway with anti-proliferative activity
  申请人：UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US10618914B2

  公开（公告）日：2020-04-14

  Compounds that selectivity inhibit the STAT3 pathway and not the STAT1 pathway and exhibit anti-proliferative activity are disclosed. Also disclosed are methods of treatment of cancers that are characterized by overexpression of STAT3, which are safer that other therapies.

  本研究公开了选择性抑制 STAT3 通路而非 STAT1 通路并具有抗增殖活性的化合物。还公开了治疗以 STAT3 过表达为特征的癌症的方法，这些方法比其他疗法更安全。
• Beger, J.; Meerbote, M., Journal fur praktische Chemie (Leipzig 1954), 1988, vol. 330, # 1, p. 119 - 125
  作者：Beger, J.、Meerbote, M.

  DOI：——

  日期：——
• BEGER, J.;MEERBOTE, M., J. PRAKT. CHEM., 330,(1988) N 1, 119-125
  作者：BEGER, J.、MEERBOTE, M.

  DOI：——

  日期：——