bis-chlorocarbonylmethylamine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: bis-chlorocarbonylmethylamine
• 英文别名: 2-[(2-Chloro-2-oxoethyl)amino]acetyl chloride；2-[(2-chloro-2-oxoethyl)amino]acetyl chloride
• 化学式: C₄H₅Cl₂NO₂
• 分子量: 169.995
• InChiKey: OYKCTAURKMVWAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-乙基吡唑-4-醇 、 bis-chlorocarbonylmethylamine 在 三乙胺 作用下， 以 水 、 甲苯 为溶剂， 生成 bis-[1-ethyl-pyrazol-4-yl-oxy]-carbonylmethylamine
  参考文献：
  名称：

  Combating pests with N-acylated N-methyl-carbamic acid O-pyrazol-4-yl

  摘要：

  公式为##STR1##的N-酰化N-甲基-氨基甲酸O-吡唑-4-基酯，其中R代表可选择取代的烷基、烯基、炔基、环烷基、芳基或芳基基团，Z代表酰基，l代表1或2，m代表1或2，n代表零或1，具有杀虫活性。

  公开号：

  US04418073A1
• 作为产物：
  描述：

  亚氨基二乙酸 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 bis-chlorocarbonylmethylamine
  参考文献：
  名称：

  1,8-Naphthalimide derivative-based turn-off fluorescent probe for the detection of picrate in organic aqueous media

  摘要：

  摘要：合成了一种简单的荧光基础的萘酰亚胺受体N-烯丙基-4-亚基二(正丁基乙酰胺)-1,8-萘酰亚胺3，作为选择性的硝酸苦味酸根（Pic–）探针，并通过荧光光谱研究了该探针的检测行为。在DMF溶液中，化合物3与不同阴离子（包括Pic–、F–、Cl–、Br–、I–、OH–、Ac–、NO3–、ClO4–、SCN–、SO32–、SO42–、H2PO4–和HPO42–）的相互作用表明，只有Pic–阴离子能够显著猝灭荧光。通过添加硝酸苦味酸根，绿黄色荧光发射被猝灭，裸眼在365 nm紫外光下容易观察到。这一现象对于制备高选择性和灵敏度的硝酸苦味酸根荧光探针至关重要。该探针可用于硝酸苦味酸根的定量，线性范围为4.97 × 10–6到6.82 × 10–5 m，检测限为5.8 × 10–7 m。最重要的是，探针3对硝酸苦味酸根具有高选择性，优于竞争性阴离子和含硝酸苦味酸根的样品，符合实际应用的选择性要求。因此，这些结果将对未来设计基于反应的荧光熄灭探针用于环境相关硝酸苦味酸根探测具有启发意义。

  DOI：

  10.1515/znb-2015-0094

文献信息

• Detection of nucleic acid amplification
  申请人：APPLIED BIOSYSTEMS LLC

  公开号：US20130164748A1

  公开（公告）日：2013-06-27

  Methods for detecting a target polynucleotide sequences are provided that utilize a probe having a target-complementary segment and a detectable tag. By cleaving the detectable tab and associating the tag with a tag complement coupled to an electrode, an electrochemical signal can be detected that is related to the presence of the tag:tag complement complex.
• ISOBARIC MASS LABELS
  申请人：Electrophoretics Limited

  公开号：US20170146549A1

  公开（公告）日：2017-05-25

  The present invention relates to a set of two or more mass labels, wherein each mass label comprises the formula: X-L-M-Re wherein X is a reporter moiety having an exact mass, L is a bond cleavable by collision in a mass spectrometer, M is a mass modifier, and Re is a) a reactive functionality for attaching the mass label to an analyte or b) the analyte, wherein each mass label in the set has an integer mass, wherein each mass label in the set has the same integer mass, and wherein the set comprises two or more subsets of mass labels, each subset comprising one, two or more mass labels, and wherein, when the subset comprises two or more mass labels, the exact mass of the reporter moiety X of each mass label in the subset is different from the exact mass of the reporter moiety X of the mass labels in the same subset and in all other subsets, and wherein each mass label is distinguishable by mass spectrometry.
• Combating pests with N-acylated N-methyl-carbamic acid O-pyrazol-4-yl
  申请人：Bayer Aktiengesellschaft

  公开号：US04418073A1

  公开（公告）日：1983-11-29

  N-Acylated N-methyl-carbamic acid O-pyrazol-4-yl esters of the formula ##STR1## in which R represents an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl or aryl radical, Z represents an acyl radical, l represents 1 or 2, m represents 1 or 2 and n represents zero or 1, which possess pesticidal activity.

  公式为##STR1##的N-酰化N-甲基-氨基甲酸O-吡唑-4-基酯，其中R代表可选择取代的烷基、烯基、炔基、环烷基、芳基或芳基基团，Z代表酰基，l代表1或2，m代表1或2，n代表零或1，具有杀虫活性。
• 1,8-Naphthalimide derivative-based turn-off fluorescent probe for the detection of picrate in organic aqueous media
  作者：Huilu Wu、Cuiping Wang、Jiawen Zhang、Yanhui Zhang、Chengyong Chen、Zaihui Yang、Xuyang Fan

  DOI：10.1515/znb-2015-0094

  日期：2015.12.1

  The synthesis of a simple fluorescent naphthalimide-based receptor N-allyl-4-iminodi(N-butylacetamide)-1,8-naphthalimide 3 was carried out as a selective picrate (Pic^–) anion probe, and the detecting behavior of this probe was studied by fluorescence spectroscopy. In DMF solution, the interaction of compound 3 with different anions, including Pic^–, F^–, Cl^–, Br^–, I^–, OH^–, Ac^–, NO₃ ^–, ClO₄ ^–, SCN^–, SO₃ ^2–, SO₄ ^2–, H₂PO₄ ^–, and HPO₄ ^2–, revealed significant fluorescence quenching only with the Pic^– anion. By adding the picrate anions, green-yellow fluorescence emission quenches, which is easily observed by naked eyes under a 365 nm UV light irradiation. This phenomenon is essential for producing a highly selective and sensitive fluorescent probe for picrate anions. The probe can be applied to the quantification of Pic^– with a linear range covering from 4.97 × 10^–6 to 6.82 × 10^–5 m and a detection limit of 5.8 × 10^–7 m. Most importantly, probe 3 has a high selectivity for picrate over competitive anions and picrate-containing analytes, which meet the selective requirements for practical application. Thus, the present results would be inspiring findings in the future design of reaction-based fluorescent turn-off probes for the environmentally relevant picrate probe.

  摘要：合成了一种简单的荧光基础的萘酰亚胺受体N-烯丙基-4-亚基二(正丁基乙酰胺)-1,8-萘酰亚胺3，作为选择性的硝酸苦味酸根（Pic–）探针，并通过荧光光谱研究了该探针的检测行为。在DMF溶液中，化合物3与不同阴离子（包括Pic–、F–、Cl–、Br–、I–、OH–、Ac–、NO3–、ClO4–、SCN–、SO32–、SO42–、H2PO4–和HPO42–）的相互作用表明，只有Pic–阴离子能够显著猝灭荧光。通过添加硝酸苦味酸根，绿黄色荧光发射被猝灭，裸眼在365 nm紫外光下容易观察到。这一现象对于制备高选择性和灵敏度的硝酸苦味酸根荧光探针至关重要。该探针可用于硝酸苦味酸根的定量，线性范围为4.97 × 10–6到6.82 × 10–5 m，检测限为5.8 × 10–7 m。最重要的是，探针3对硝酸苦味酸根具有高选择性，优于竞争性阴离子和含硝酸苦味酸根的样品，符合实际应用的选择性要求。因此，这些结果将对未来设计基于反应的荧光熄灭探针用于环境相关硝酸苦味酸根探测具有启发意义。