4-(5-hydroxy-4-oxo-7-(propionyloxy)-4H-chromen-2-yl)-1,2-phenylene dipropionate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 4-(5-hydroxy-4-oxo-7-(propionyloxy)-4H-chromen-2-yl)-1,2-phenylene dipropionate
• 英文别名: [4-(5-Hydroxy-4-oxo-7-propanoyloxychromen-2-yl)-2-propanoyloxyphenyl] propanoate；[4-(5-hydroxy-4-oxo-7-propanoyloxychromen-2-yl)-2-propanoyloxyphenyl] propanoate
• 化学式: C₂₄H₂₂O₉
• 分子量: 454.433
• InChiKey: ZVRSVZDTJYCKKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  125
• 氢给体数：
  1
• 氢受体数：
  9

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  木犀草素	2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-on	491-70-3	C15H10O6	286.241

反应信息

• 作为产物：
  描述：

  木犀草素 、 丙酸酐 在 吡啶 作用下， 以15%的产率得到4-(5-hydroxy-4-oxo-7-(propionyloxy)-4H-chromen-2-yl)-1,2-phenylene dipropionate
  参考文献：
  名称：

  [EN] ACYLATED CATECHIN POLYPHENOLS AND METHODS OF THEIR USE FOR THE TREATMENT OF CANCER
  [FR] POLYPHÉNOLS DE CATÉCHINE ACYLÉS ET LEURS PROCÉDÉS D'UTILISATION POUR LE TRAITEMENT DU CANCER

  摘要：

  公开号：

  WO2019236765A8

文献信息

• Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US10953027B2

  公开（公告）日：2021-03-23

  Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.

  本文公开了活性剂、含有活性剂的组合物、含有活性剂的单位剂型以及活性剂的使用方法，例如用于治疗代谢紊乱或非酒精性脂肪肝或调节代谢标志物或非酒精性脂肪肝标志物。
• Acylated active agents and methods of their use for the treatment of autoimmune disorders
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US11058698B2

  公开（公告）日：2021-07-13

  Disclosed herein are acylated active agents and methods of their use, e.g., for modulating an autoimmunity marker or for treating an autoimmune disorder.

  本文公开了酰化活性剂及其使用方法，例如用于调节自身免疫标记物或治疗自身免疫性疾病的方法。
• ACYLATED CATECHIN POLYPHENOLS AND METHODS OF THEIR USE FOR THE TREATMENT OF CANCER
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：EP3801587A1

  公开（公告）日：2021-04-14
• ACYLATED ACTIVE AGENTS AND METHODS OF THEIR USE FOR THE TREATMENT OF AUTOIMMUNE DISORDERS
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20200188418A1

  公开（公告）日：2020-06-18

  Disclosed herein are acylated active agents and methods of their use, e.g., for modulating an autoimmunity marker or for treating an autoimmune disorder.
• ACTIVE AGENTS AND METHODS OF THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS AND NONALCOHOLIC FATTY LIVER DISEASE
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20200197428A1

  公开（公告）日：2020-06-25

  Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.