tert-butyl N-(2,5-dibromophenyl)carbamate | 1310923-60-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-(2,5-dibromophenyl)carbamate
• 英文别名: tert-butyl (2,5-dibromophenyl)carbamate
• CAS: 1310923-60-4
• 化学式: C₁₁H₁₃Br₂NO₂
• 分子量: 351.038
• InChiKey: SLTLTMAFOMKOTL-UHFFFAOYSA-N

物化性质

• 沸点：
  317.5±32.0 °C(Predicted)
• 密度：
  1.665±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  tert-butyl N-(2,5-dibromophenyl)carbamate 在 potassium phosphate 、 四(三苯基膦)钯 、 potassium tert-butylate 、 甲基锂 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醚 、 水 为溶剂， 反应 9.17h， 生成
  参考文献：
  名称：

  确认螺螺吲哚和二苯并氮杂pine基序为有效的盐皮质激素受体拮抗剂

  摘要：

  盐皮质激素受体（MR）拮抗剂继续是制药行业研究的主要领域。在本文中，我们报道了作为有效的MR拮抗剂的各种螺氧杂吲哚和二苯并x庚因构建物的发现。SAR分析我们的螺氧杂吲哚导致了含有极性增溶基团的高效化合物，这些基团与MR配体结合域（LBD）的11螺旋区域相互作用。为了替代已知的与MR LBD的疏水区相互作用的二苯并庚烷体系，还制备了各种二苯并x庚因部分。另外，从高效化合物获得了X射线晶体结构，该化合物显示出针对MR的部分激动剂和拮抗剂作用模式。

  DOI：

  10.1016/j.bmc.2016.02.014
• 作为产物：
  描述：

  2,5-二溴苯甲酸 在 sodium azide 、 草酰氯 、 tetra(n-tert-butyl)ammonium bromide 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 3.5h， 生成 tert-butyl N-(2,5-dibromophenyl)carbamate
  参考文献：
  名称：

  Synthesis and Characterization of Solution-Processable Ladderized n-Type Naphthalene Bisimide Copolymers for OFET Applications

  摘要：

  Solution-processable n-type ladder-based polymers are highly desirable due to their potential capability to form strong. pi-pi interactions. A series of 5 highly soluble naphthalene diimide (NDI) polymers are presented, differing in the degree to which they are able to form imine-bridged ladder polymer structures. Average electron mobilities as high as 0.0026 cm(2) V(-1) s(-1), which show an electron-mobility improvement of 4 orders of magnitude following ladderization, and on/off current ratios on the order of 10(4) are reported for the novel material PNDI-2BocL, an alkyl-substituted poly(benzoquinolinophenanthrolinedione). The structure property relationship of the aforementioned series of copolymers is presented and discussed as it pertains to organic field-effect transistor (OFET) performance.

  DOI：

  10.1021/ma2004822

文献信息

• Metal–Organic Frameworks with Precisely Designed Interior for Carbon Dioxide Capture in the Presence of Water
  作者：Alejandro M. Fracaroli、Hiroyasu Furukawa、Mitsuharu Suzuki、Matthew Dodd、Satoshi Okajima、Felipe Gándara、Jeffrey A. Reimer、Omar M. Yaghi

  DOI：10.1021/ja503296c

  日期：2014.6.25

  The selective capture of carbon dioxide in the presence of water is an outstanding challenge. Here, we show that the interior of IRMOF-74-III can be covalently functionalized with primary amine (IRMOF-74-III-CH2NH2) and used for the selective capture of CO2 in 6596 relative humidity. This study encompasses the synthesis, structural characterization, gas adsorption, and CO2 capture properties of variously functionalized IRMOF-74-III compounds (IRMOF-74-III-CH3, -NH2, -CH(2)NHBoc, -CH(2)NMeBoc, -CH2NH2, and -CH2NHMe). Cross-polarization magic angle spinning C-13 NMR spectra showed that CO2 binds chemically to IRMOF-74-III-CH2NH2 and -CH2NHMe to make carbamic species. Carbon dioxide isotherms and breakthrough experiments show that IRMOF-74-III-CH2NH2 is especially efficient at taking up CO2 (3.2 mmol of CO2 per gram at 800 Torr) and, more significantly, removing CO2 from wet nitrogen gas streams with breakthrough time of 610 +/- 10 s g(-1) and full preservation of the IRMOF structure.
• [EN] METAL ORGANIC FRAMEWORKS COMPRISING A PLURALITY OF SBUS WITH DIFFERENT METAL IONS AND/OR A PLURALITY OF ORGANIC LINKING LIGANDS WITH DIFFERENT FUNCTIONAL GROUPS.<br/>[FR] RÉSEAUX MÉTAL-ORGANIQUES COMPRENANT UNE PLURALITÉ DE SBU AVEC DIFFÉRENTS IONS MÉTALLIQUES ET/OU UNE PLURALITÉ DE LIGANDS DE LIAISON ORGANIQUE AVEC DIFFÉRENTS GROUPES FONCTIONNELS
  申请人：UNIV CALIFORNIA

  公开号：WO2015195179A3

  公开（公告）日：2016-05-26
• [EN] CROSS-LINKED CARBON NANOTUBE NETWORKS<br/>[FR] RÉSEAUX DE NANOTUBES DE CARBONE RÉTICULÉS
  申请人：[en]IMPERIAL COLLEGE INNOVATIONS LIMITED

  公开号：WO2022123227A1

  公开（公告）日：2022-06-16

  Described herein are processes for preparing covalently cross-linked carbon nanotube networks. The covalently cross-linked carbon nanotube networks comprise carbon nanotubes covalently linked by a linker formed from a linker precursor. The covalently cross-linked carbon nanotube networks described herein may have utility in gas sensing applications.
• Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists
  作者：Stephen D. Lotesta、Andrew P. Marcus、Yajun Zheng、Katerina Leftheris、Paul B. Noto、Shi Meng、Geeta Kandpal、Guozhou Chen、Jing Zhou、Brian McKeever、Yuri Bukhtiyarov、Yi Zhao、Deepak S. Lala、Suresh B. Singh、Gerard M. McGeehan

  DOI：10.1016/j.bmc.2016.02.014

  日期：2016.3

  Mineralocorticoid receptor (MR) antagonists continue to be a prevalent area of research in the pharmaceutical industry. Herein we report the discovery of various spirooxindole and dibenzoxazepine constructs as potent MR antagonists. SAR analysis of our spirooxindole hit led to highly potent compounds containing polar solubilizing groups, which interact with the helix-11 region of the MR ligand binding

  盐皮质激素受体（MR）拮抗剂继续是制药行业研究的主要领域。在本文中，我们报道了作为有效的MR拮抗剂的各种螺氧杂吲哚和二苯并x庚因构建物的发现。SAR分析我们的螺氧杂吲哚导致了含有极性增溶基团的高效化合物，这些基团与MR配体结合域（LBD）的11螺旋区域相互作用。为了替代已知的与MR LBD的疏水区相互作用的二苯并庚烷体系，还制备了各种二苯并x庚因部分。另外，从高效化合物获得了X射线晶体结构，该化合物显示出针对MR的部分激动剂和拮抗剂作用模式。
• Synthesis and Characterization of Solution-Processable Ladderized n-Type Naphthalene Bisimide Copolymers for OFET Applications
  作者：Matthew M. Durban、Peter D. Kazarinoff、Yukari Segawa、Christine K. Luscombe

  DOI：10.1021/ma2004822

  日期：2011.6.28

  Solution-processable n-type ladder-based polymers are highly desirable due to their potential capability to form strong. pi-pi interactions. A series of 5 highly soluble naphthalene diimide (NDI) polymers are presented, differing in the degree to which they are able to form imine-bridged ladder polymer structures. Average electron mobilities as high as 0.0026 cm(2) V(-1) s(-1), which show an electron-mobility improvement of 4 orders of magnitude following ladderization, and on/off current ratios on the order of 10(4) are reported for the novel material PNDI-2BocL, an alkyl-substituted poly(benzoquinolinophenanthrolinedione). The structure property relationship of the aforementioned series of copolymers is presented and discussed as it pertains to organic field-effect transistor (OFET) performance.