α,α-difluoro-β-hydroxy-3-(2-pyridinyl)propanoic acid, hydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: α,α-difluoro-β-hydroxy-3-(2-pyridinyl)propanoic acid, hydrazide
• 英文别名: alpha,alpha-Difluoro-beta-hydroxy-3-(2-pyridinyl)propanoic acid, hydrazide；2,2-difluoro-3-hydroxy-3-pyridin-2-ylpropanehydrazide
• 化学式: C₈H₉F₂N₃O₂
• 分子量: 217.175
• InChiKey: NLMQRKXFHLQLJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  88.2
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carbonyl chloride 、 α,α-difluoro-β-hydroxy-3-(2-pyridinyl)propanoic acid, hydrazide 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 以59%的产率得到8-chlorodibenz<1,4>oxazepine-10(11H)-carboxylic acid, 2-<2,2-difluoro-3-hydroxy-1-oxo-3-(2-pyridinyl)propyl>hydrazide
  参考文献：
  名称：

  N-Substituted dibenzoxazepines as analgesic PGE2 antagonists

  摘要：

  8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide (1, SC-19220) has been previously reported by us and others to be a PGE2 antagonist selective for the EP1 receptor subtype1 with antinociceptive activities.2 Analogs of SC-19220, in which the acetyl moiety has been replaced with pyridylpropionyl groups and their homologs, have been synthesized as illustrated by compounds 13 and 29. These and other members of this series have been shown to be efficacious analgesics and PGE2 antagonists of the EP1 subtype. This report discusses the structure activity relationships within this series.

  DOI：

  10.1021/jm00074a010
• 作为产物：
  描述：

  ethyl α,α-difluoro-β-hydroxy-3-(2-pyridinyl)propanoate 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 16.0h， 以72%的产率得到α,α-difluoro-β-hydroxy-3-(2-pyridinyl)propanoic acid, hydrazide
  参考文献：
  名称：

  N-Substituted dibenzoxazepines as analgesic PGE2 antagonists

  摘要：

  8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-acetylhydrazide (1, SC-19220) has been previously reported by us and others to be a PGE2 antagonist selective for the EP1 receptor subtype1 with antinociceptive activities.2 Analogs of SC-19220, in which the acetyl moiety has been replaced with pyridylpropionyl groups and their homologs, have been synthesized as illustrated by compounds 13 and 29. These and other members of this series have been shown to be efficacious analgesics and PGE2 antagonists of the EP1 subtype. This report discusses the structure activity relationships within this series.

  DOI：

  10.1021/jm00074a010

文献信息

• Substituted dibenzoxazepine compounds
  申请人：G. D. Searle & Co.

  公开号：US05378840A1

  公开（公告）日：1995-01-03

  The present invention provides dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

  本发明提供了公式I的二苯并噁唑化合物：##STR1## 作为用于治疗疼痛的镇痛剂，其中包括与药学上可接受的载体组合的公式I化合物的治疗有效量的药物组合物，以及通过向动物投与公式I化合物的治疗有效量来消除或缓解动物疼痛的方法。
• Substituted dibenzoxapine compounds, pharmaceutical compositions and
  申请人：G. D. Searle & Co.

  公开号：US05464830A1

  公开（公告）日：1995-11-07

  The present invention provides dibenzoxazepine compounds, of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

  本发明提供了二苯并噁唑化合物，化学式为I：##STR1## 该化合物可用作镇痛剂，用于治疗疼痛，药物组合物包括化合物I的治疗有效量与药物可接受载体的组合，以及一种用于消除或缓解动物疼痛的方法，包括向动物施用化合物I的治疗有效量。
• Substituted dibenzoxazepine compounds and methods for treating
  申请人：G.D. Searle & Co.

  公开号：US05576315A1

  公开（公告）日：1996-11-19

  The present invention provides dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

  本发明提供了一种二苯并噁唑化合物，其化学式为I：##STR1## 该化合物可用作镇痛剂治疗疼痛，药物组合物包括一种化合物I的治疗有效量和药学上可接受的载体，以及一种用于消除或缓解动物疼痛的方法，包括向动物投与化合物I的治疗有效量。
• Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
  申请人：G.D. Searle & Co.

  公开号：EP0512400A1

  公开（公告）日：1992-11-11

  The present invention provides dibenzoxazepine compounds of Formula I: which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

  本发明提供了式 I 的二苯并氧氮杂卓化合物： 可用作治疗疼痛的镇痛剂；包含治疗有效量的式 I 化合物与药学上可接受的载体的药物组合物；以及消除或改善动物疼痛的方法，该方法包括对动物施用治疗有效量的式 I 化合物。
• SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE
  申请人：G.D. SEARLE & CO.

  公开号：EP0583421A1

  公开（公告）日：1994-02-23