Synthesis of modified uracil and cytosine nucleobases using a microwave-assisted method
作者:Laxmi Narayana Burgula、K. Radhakrishnan、Lal Mohan Kundu
DOI:10.1016/j.tetlet.2012.03.056
日期:2012.5
Modified nucleobases and nucleic acids have found many biological and pharmaceutical applications. Here we report a microwave-directed synthesis of a variety of modified uracil and cytosine nucleobases with high yields under solvent-free conditions. The reaction yields were further improved by addition of Lewis acid. The crystal structures of 5-isopropyl-6-methyluracil and 6-phenyluracil were also determined. (C) 2012 Elsevier Ltd. All rights reserved.