2-Hydroxy-buttersaeure-butylester | 13544-79-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Hydroxy-buttersaeure-butylester
• 英文别名: n-butyl 2-hydroxybutanoate；butyl hydroxybutyrate；2-hydroxy-butyric acid butyl ester；Rac-Butyl 2-Hydroxybutanoate；butyl 2-hydroxybutanoate
• CAS: 13544-79-1
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: YFFBWGUXPFAXRS-UHFFFAOYSA-N

物化性质

• 沸点：
  84-87 °C(Press: 9 Torr)
• 密度：
  0.957 g/cm3(Temp: 21 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-丁烯酸丁酯 在 三乙基硅烷 、 [5,10,15,20-tetra(2,6-dichlorophenyl)porphyrinato]cobalt(II) 、 氧气 、 三甲氧基磷 作用下， 生成 2-Hydroxy-buttersaeure-butylester
  参考文献：
  名称：

  钴 (II) 卟啉催化还原氧化，然后用亚磷酸三甲酯还原，由芳香族烯烃和丙烯酸衍生物一锅法制备醇

  摘要：

  在催化量的钴 (II) 卟啉存在下，通过氧和三乙基硅烷的还原氧化，各种芳族烯烃和丙烯酸衍生物以良好的收率转化为苯甲醇和 α-羟基链烷酸衍生物，然后用三甲基卟啉处理反应混合物。亚磷酸盐。

  DOI：

  10.1246/cl.1993.925

文献信息

• [EN] POLYGLYOXYLATES, MANUFACTURE AND USE THEREOF<br/>[FR] POLYGLYOXYLATES, LEUR PRODUCTION ET LEUR UTILISATION
  申请人：UNIV WESTERN ONTARIO

  公开号：WO2015168809A1

  公开（公告）日：2015-11-12

  Self-immolative polymers degrade by an end-to-end depolymerisation mechanism in response to the cleavage of a stabilizing end-cap from the polymer terminus. Examples include homopolymers, mixed polymers including block copolymers, suitable for a variety of applications. A polyglyoxylate can be end-capped or capped with a linker as in a block copolymer.

  自焚式聚合物通过从聚合物末端切割稳定端盖，以端到端解聚机制进行降解。例如包括均聚物、混合聚合物包括区块共聚物，适用于各种应用。聚乙二醇酸可以端接或与连接剂如区块共聚物一样封端。
• Substances and Pharmaceutical Compositions for the Inhibition of Glyoxalases and Their Use As Anti-Fungal Agents
  申请人：Huse Klaus

  公开号：US20080300303A1

  公开（公告）日：2008-12-04

  The present invention pertains to substances of the formula (I) wherein X is O or S; and R1-R4 are defined in the claims as inhibitors of glyoxalase I and/or II, pharmaceutical compositions comprising one or more compounds according to formula (I) and the use of one or more compounds according to formula (I) for the treatment of diseases associated with increased glycolytic metabolism. In one embodiment, the disease is a fungal infection.

  本发明涉及式（I）的物质，其中X是O或S; R1-R4在权利要求中定义为乙醛酸酯酶I和/或II的抑制剂，包含一个或多个式（I）化合物的制药组合物以及使用一个或多个式（I）化合物治疗与增加的糖酵解代谢相关的疾病。在一种实施方式中，该疾病是真菌感染。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE ESTER
  申请人：Araki Takaaki

  公开号：US20090118535A1

  公开（公告）日：2009-05-07

  A process for producing an optically active 2-hydroxybutyric ester (1), characterized by including reacting an optically active 2,3-epoxybutyric ester (2) with a thiol in the presence of scandium trifluoromethanesulfonate or ytterbium trifluoromethanesulfonate, to thereby produce Compound (3), and subjecting Compound (3) to desulfurization reaction: (wherein R represents a C1 to C6 alkyl group or a C7 or C8 aralkyl group; R 1 represents a C1 to C12 alkyl group or a phenyl group; and * represents S- or R-absolute configuration). The present invention provides a process for producing an optically active 2-hydroxybutyric ester at high yield and high optical purity.

  一种生产光学活性2-羟基丁酸酯（1）的方法，其特征在于在三氟甲烷磺酸钪或三氟甲烷磺酸镱存在下，用巯基反应光学活性2,3-环氧丁酸酯（2），从而产生化合物（3），并将化合物（3）进行脱硫化反应：（其中R表示C1到C6烷基或C7或C8芳基烷基；R1表示C1到C12烷基或苯基；*表示S-或R-绝对构型）。本发明提供了一种高产率和高光学纯度的生产光学活性2-羟基丁酸酯的方法。
• PRESSURE-SENSITIVE ADHESIVES PREPARED FROM DEGRADABLE MONOMERS AND POLYMERS
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US20150337179A1

  公开（公告）日：2015-11-26

  Pressure-sensitive adhesives that have good performance characteristics under typical use conditions and that later can be degraded and/or removed readily under basic conditions are provided. More specifically, the pressure-sensitive adhesives contain a copolymeric (meth)acrylic-based elastomeric material prepared from a polymerizable material that contains a (meth)acrylate monomer having both a (meth)acryloyl group plus an ester linkage that is not part of a (meth)acryloyl group.

  提供了在典型使用条件下具有良好性能特征并在碱性条件下可以轻易降解和/或去除的压敏粘合剂。更具体地说，这些压敏粘合剂包含一种共聚的（甲基）丙烯酸基弹性材料，该材料是由一种含有（甲基）丙烯酸酯单体的聚合物材料制备而成，该单体具有（甲基）丙烯酰基和不是（甲基）丙烯酰基的酯键。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE 2-HYDROXYBUTYRIC ESTER
  申请人：Koura Minoru

  公开号：US20090209780A1

  公开（公告）日：2009-08-20

  To provide a process for producing an optically active 2-hydroxybutyric ester at high yield and high optical purity. The process for producing an optically active 2-hydroxybutyric ester (1), characterized in that the process includes reacting an optically active 2,3-epoxypropionic ester (2) with a methyl Grignard reagent CH 3 MgX (wherein X represents a halogen atom) in the presence of a copper catalyst in an amount of 0.05 to 0.5 mol with respect to 1 mol of (2) through the following scheme: (wherein R represents a C1 to C6 alkyl group or a C7 or C8 aralkyl group; X represents a halogen atom; and * represents S- or R-absolute configuration).

  提供一种高产率和高光学纯度的光学活性2-羟基丁酸酯的生产过程。生产光学活性2-羟基丁酸酯（1）的过程，其特征在于该过程包括通过以下方案将光学活性2,3-环氧丙酸酯（2）与甲基格氏试剂CH3MgX（其中X代表卤素原子）在铜催化剂的存在下反应，铜催化剂的用量相对于（2）的1摩尔为0.05至0.5摩尔：（其中R代表C1至C6烷基或C7或C8芳基烷基；X代表卤素原子；*代表S-或R-绝对构型）。