{2-[2-(phenylamino)phenyl]acetyl}hydrazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: {2-[2-(phenylamino)phenyl]acetyl}hydrazine
• 英文别名: 2-(2-Anilinophenyl)acetohydrazide
• 化学式: C₁₄H₁₅N₃O
• 分子量: 241.293
• InChiKey: AEGSNUOSYRKXRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  67.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯-N,N-二苯基乙酰胺 在 sodium hydroxide 、 三氯化铝 、 氯化亚砜 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 8.0h， 生成 {2-[2-(phenylamino)phenyl]acetyl}hydrazine
  参考文献：
  名称：

  Design, synthesis and in vivo anticonvulsant screening in mice of Novel phenylacetamides

  摘要：

  A set of seven novel N-substituted 2-anilinophenylacetamides were designed by pharmacophore generation and using flexible alignment module of MOE software. The novel molecules were synthesized and screened for anticonvulsant activity in Swiss albino mice by MES and ScPTZ induced seizure tests. Test compounds were found to be potent in MES test. Compounds 12 and 14 were found to be more potent with ED50 values 24.0 and 8.0 mg kg(-1), respectively, and their activity was comparable to standard drugs (Phenytoin, Carbamazepine). Test compounds did not show significant activity in ScPTZ test. Compounds 12 and 14 also exhibited higher protective indices (20.3 and 87.5, respectively) when assessed for neurotoxicity by rotarod test as compared to the standards. (c) 2006 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2006.03.013

文献信息

• Design, synthesis and in vivo anticonvulsant screening in mice of Novel phenylacetamides
  作者：A.V. Shindikar、F. Khan、C.L. Viswanathan

  DOI：10.1016/j.ejmech.2006.03.013

  日期：2006.6

  A set of seven novel N-substituted 2-anilinophenylacetamides were designed by pharmacophore generation and using flexible alignment module of MOE software. The novel molecules were synthesized and screened for anticonvulsant activity in Swiss albino mice by MES and ScPTZ induced seizure tests. Test compounds were found to be potent in MES test. Compounds 12 and 14 were found to be more potent with ED50 values 24.0 and 8.0 mg kg(-1), respectively, and their activity was comparable to standard drugs (Phenytoin, Carbamazepine). Test compounds did not show significant activity in ScPTZ test. Compounds 12 and 14 also exhibited higher protective indices (20.3 and 87.5, respectively) when assessed for neurotoxicity by rotarod test as compared to the standards. (c) 2006 Elsevier SAS. All rights reserved.