2-(Carbomethoxy)-2-(4-pentenyl)cyclopentanone | 74283-18-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(Carbomethoxy)-2-(4-pentenyl)cyclopentanone
• 英文别名: 2-oxo-1-pent-4-enyl-cyclopentanecarboxylic acid methyl ester；Methyl 2-oxo-1-pent-4-enylcyclopentane-1-carboxylate；methyl 2-oxo-1-pent-4-enylcyclopentane-1-carboxylate
• CAS: 74283-18-4
• 化学式: C₁₂H₁₈O₃
• 分子量: 210.273
• InChiKey: XTUCAUHARBHWTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(Carbomethoxy)-2-(4-pentenyl)cyclopentanone 在 氢氧化钾 、 硫酸 作用下， 生成 2-(4-pentenyl)cyclopentan-1-one
  参考文献：
  名称：

  Extension of a Nuphar piperidine synthesis to quinolizidines and an indolizidine

  摘要：

  DOI：

  10.1021/jo01306a024
• 作为产物：
  描述：

  5-碘-1-戊烯 、 2-甲氧羰基环戊酮 在 sodium hydride 作用下， 生成 2-(Carbomethoxy)-2-(4-pentenyl)cyclopentanone
  参考文献：
  名称：

  Extension of a Nuphar piperidine synthesis to quinolizidines and an indolizidine

  摘要：

  DOI：

  10.1021/jo01306a024

文献信息

• Synthesis of Various Bridged Ring Systems via Rhodium-Catalyzed Bridged (3+2) Cycloadditions
  作者：Yu-Tao He、Li-Xuan Li、Xiaohong Lin、Bao-Long Hou、Chuang-Chuang Li

  DOI：10.1021/acs.orglett.1c03837

  日期：2022.1.14

  N-sulfonyl-1,2,3-triazoles, which allowed the efficient diastereoselective construction of various functionalized and synthetically challenging bridged ring systems. This simple, direct transformation had a broad substrate scope and excellent functional group tolerance. The highly strained polycyclic bicyclo[2.2.2]octa[b]indole core of fruticosine was synthesized efficiently using this methodology.

  在这里，我们描述了N-磺酰基-1,2,3-三唑的铑催化桥接 (3+2) 环加成级联反应，这使得各种功能化和合成具有挑战性的桥接环系统的有效非对映选择性构建成为可能。这种简单、直接的转化具有广泛的底物范围和出色的官能团耐受性。使用该方法有效地合成了果糖苷的高应变多环双环[2.2.2]octa[ b ]吲哚核。
• Ruthenium Carbene Complexes with <i>N</i>,<i>N</i>‘-Bis(mesityl)imidazol-2-ylidene Ligands:  RCM Catalysts of Extended Scope
  作者：Alois Fürstner、Oliver R. Thiel、Lutz Ackermann、Hans-Jörg Schanz、Steven P. Nolan

  DOI：10.1021/jo9918504

  日期：2000.4.1

  The ruthenium carbene complexes 3a,b bearing imidazol-2-ylidene ligands constitute excellent precatalysts for ring-closing metathesis (RCM) reactions allowing the formation of tri- and tetrasubstituted cycloalkenes. They also apply to annulations that are beyond the scope of the standard Grubbs carbene 1 as well as to ring-closing reactions of acrylic acid derivatives even if the resulting alpha,beta-unsaturated lactones (or lactams) are tri- or tetrasubstituted. The reactivity of 3a was found to be highly dependent on the reaction medium: particularly high reaction rates are observed in toluene, although this solvent also leads to an increased tendency of the catalyst to isomerize the double bonds of the substrates.