4-(n-hexyloxy)-3-ethoxybenzaldehyde | 339074-51-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(n-hexyloxy)-3-ethoxybenzaldehyde
• 英文别名: 3-ethoxy-4-hexyloxybenzaldehyde；3-Ethoxy-4-(hexyloxy)benzaldehyde；3-ethoxy-4-hexoxybenzaldehyde
• CAS: 339074-51-0
• 化学式: C₁₅H₂₂O₃
• mdl: MFCD09718759
• 分子量: 250.338
• InChiKey: UKYSGFDCRKZKPC-UHFFFAOYSA-N

物化性质

• 沸点：
  364.5±22.0 °C(Predicted)
• 密度：
  1.008±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.533
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(n-hexyloxy)-3-ethoxybenzaldehyde 在 sodium tetrahydroborate 作用下， 以 异丙醇 为溶剂， 反应 4.0h， 以70%的产率得到3-Ethoxy-4-(hexyloxy)benzenemethanol
  参考文献：
  名称：

  Esters of benzoic, 5-arylisoxazole-3-carboxylic and 4,5-dichloroisothiazole-3-carboxylic acids

  摘要：

  DOI：

  10.1134/s107036321406019x

文献信息

• Studies on antidiabetic agents. III. 5-Arylthiazolidine-2,4-diones as potent aldose reductase inhibitors.
  作者：TAKASHI SOHDA、KATSUTOSHI MIZUNO、EIKO IMAMIYA、HIROYUKI TAWADA、KANJI MEGURO、YUTAKA KAWAMATSU、YUJIRO YAMAMOTO

  DOI：10.1248/cpb.30.3601

  日期：——

  Thiazolidine-2, 4-dione derivatives having one or two substituent (s) such as phenyl, heteryl and alkyl group (s) at the 5-position were synthesized and evaluated as aldose reductase inhibitors. Inhibition by the active compounds of the swelling of the lens in a rat-lens-culture assay was also measured. Among these compounds, a series of 5-(3, 4-dialkoxyphenyl) thiazolidine-2, 4-diones showed pronounced activities in both assays. Structure-activity relationships are discussed and a new approach to the synthesis of 5-arylthiazolidine-2, 4-diones is described.

  具有一个或两个取代基（如苯基、杂基和烷基）的噻唑烷-2,4-二酮衍生物在5位合成并评估为醛糖还原酶抑制剂。在鼠晶状体培养检测中，活性化合物的抑制作用也被测量。在这些化合物中，一系列5-(3,4-二烷氧基苯基)噻唑烷-2,4-二酮在两种检测中显示出显著的活性。结构-活性关系进行了讨论，并描述了一种合成5-芳基噻唑烷-2,4-二酮的新方法。
• Synthesis, Characterization, and Mesomorphic Properties of New Pyridine Derivatives
  作者：Ahipa T. N.

  DOI：10.1002/open.201500158

  日期：2015.12

  Luminescent liquid crystals have received significant research interest due to their wide range of applications. Here, new pyridine derivatives were designed as liquid crystalline materials. They were successfully synthesized via appropriate synthetic routes, their structures confirmed by various spectral techniques, and finally characterized for their mesogenic, optical and optoelectronic properties

  发光液晶由于其广泛的应用而受到了广泛的研究兴趣。在这里，新的吡啶衍生物被设计为液晶材料。它们是通过适当的合成路线成功合成的，其结构已通过各种光谱技术证实，并最终通过介晶，光学和光电特性进行了表征。
• Compositions containing aromatic aldehydes and their use in treatments
  申请人：——

  公开号：US20030124157A1

  公开（公告）日：2003-07-03

  Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. Some of the compositions are useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.

  揭示了含有芳香醛类化合物的药用和化妆品组合物。其中一些组合物可用作治疗炎症性皮肤病的局部治疗药物。其中一些组合物可用于治疗哺乳动物体内其他炎症性疾病的经皮和其他系统剂型。
• Synthesis and antibacterial activity of alkyl derivatives of the glycopeptide antibiotic A40926 and their amides
  作者：Sonia I. Maffioli、Romeo Ciabatti、Gabriella Romanò、Ettore Marzorati、Maria Preobrazhenskaya、Andrej Pavlov

  DOI：10.1016/j.bmcl.2005.05.076

  日期：2005.8

  New derivatives of the glycopeptide antibiotic A40926 were synthesized and evaluated for antimicrobial activity against VRE. Deacylated A40926 was obtained by microbial transformation of the parent antibiotic with the use of Actinoplanes teichomyceticus ATCC 31121. Regioselective synthesis of alkylated derivatives of Deacyl A40926 was carried out using lipophilic aliphatic and aromatic halides or aldehydes

  合成了糖肽抗生素A40926的新衍生物，并评估了其对VRE的抗菌活性。通过使用Actinoplanes teichomyceticus ATCC 31121对母体抗生素进行微生物转化来获得脱酰A40926。使用亲脂性脂族和芳族卤化物或醛进行脱酰基A40926烷基化衍生物的区域选择性合成。进行了两种羧酸的进一步修饰以增加抗生素活性。对于通过分子上存在的氨基的亲脂性单烷基或二烷基化获得的衍生物，观察到的抗菌活性差，同时疏水性衍生物中的两个羧基与二元胺同时缩合导致抗生素活性大大提高。
• New columnar liquid crystal materials based on luminescent 2-methoxy-3-cyanopyridines
  作者：T. N. Ahipa、Vijith Kumar、Airody Vasudeva Adhikari

  DOI：10.1007/s11224-014-0390-x

  日期：2014.8

  A new series of donor–acceptor–donor (D–A–D) type luminescent mesogens carrying 2-methoxy-3-cyanopyridine as a central core linked with variable alkoxy chain lengths (m = 6 and 8) as terminal substituents was synthesized and characterized using spectral methods. The newly synthesized molecules were subjected to single-crystal X-ray diffraction (SCXRD), powder X-ray diffraction (PXRD), differential scanning calorimetric (DSC), polarizing optical microscopy (POM), and fluorescence emission studies in order to ascertain their mesogenic and photophysical properties. The SCXRD data on 4a and 4b reveal that the presence of short intermolecular contacts, viz. C–H···N, C–H···O, C–H···π, and π···π interactions, is responsible for their crystal packing. The measured torsion angle values indicate that molecules possess distorted non-planar structure. The DSC, POM, and PXRD studies confirm that all the molecules show thermotropic liquid crystalline behaviour and exhibit rectangular columnar phase. Further, their UV–visible and fluorescence spectral studies reveal that the target molecules are luminescent displaying a strong absorption band in the range of 335–340 nm and a blue fluorescence emission band in the range of 395–425 nm (both in solution and film state) with good fluorescence quantum yields (10–49 %).

  以 2-甲氧基-3-氰基吡啶为中心核，以可变烷氧基链长度（m = 6 和 8）为末端取代基，合成了一系列新的供体-受体-供体（D-A-D）型发光介质，并利用光谱方法对其进行了表征。对新合成的分子进行了单晶 X 射线衍射（SCXRD）、粉末 X 射线衍射（PXRD）、差示扫描量热（DSC）、偏振光学显微镜（POM）和荧光发射研究，以确定它们的介电性和光物理性质。4a 和 4b 的 SCXRD 数据显示，它们的晶体结构是由分子间的短接触（即 C-H--N、C-H--O、C-H--π 和 π--π 相互作用）造成的。测量到的扭转角值表明，分子具有扭曲的非平面结构。DSC、POM 和 PXRD 研究证实，所有分子都表现出热致液晶行为，并呈现矩形柱状相。此外，它们的紫外-可见光和荧光光谱研究表明，目标分子具有发光特性，在 335-340 nm 范围内显示出强吸收带，在 395-425 nm 范围内显示出蓝色荧光发射带（溶液和薄膜状态下均是），并具有良好的荧光量子产率（10-49 %）。