bis[2-(4-pyridyl)ethyl]phosphine oxide | 205323-66-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: bis[2-(4-pyridyl)ethyl]phosphine oxide
• 英文别名: bis[2-(4-pyridyl)ethyl]phosphinic acid
• CAS: 205323-66-6
• 化学式: C₁₄H₁₇N₂OP
• 分子量: 260.276
• InChiKey: MVRSBHOFHLISKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.82
• 重原子数：
  18.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  42.85
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  苯乙烯 、 bis[2-(4-pyridyl)ethyl]phosphine oxide 在 对苯二酚 、 potassium hydroxide 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 8.5h， 以52%的产率得到bis[2-(4-pyridyl)ethyl]phenylethylphosphine oxide
  参考文献：
  名称：

  Synthesis and properties of a new family of phosphorus- and nitrogen-containing ionenes

  摘要：

  Polyquaternization reactions of bis[2-(4-pyridyl)ethyl]phenylethylphosphine oxide and tris[2-(4-pyridyl)ethyl]phosphine oxide with 1,4-dibromobutane were implemented for the first time to give linear (water-soluble) and cross-linked (limitedly water swelling), respectively, representatives of new phosphorus- and nitrogen-containing ionenes. The synthesized linear ionenes react with heparin and polyacrylic acid yielding water-insoluble polyelectrolyte complexes.

  DOI：

  10.1134/s0012500815120034
• 作为产物：
  描述：

  4-乙烯基吡啶 在 氧气 、 phosphan 、 potassium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 生成 bis[2-(4-pyridyl)ethyl]phosphine oxide
  参考文献：
  名称：

  Synthesis and properties of a new family of phosphorus- and nitrogen-containing ionenes

  摘要：

  Polyquaternization reactions of bis[2-(4-pyridyl)ethyl]phenylethylphosphine oxide and tris[2-(4-pyridyl)ethyl]phosphine oxide with 1,4-dibromobutane were implemented for the first time to give linear (water-soluble) and cross-linked (limitedly water swelling), respectively, representatives of new phosphorus- and nitrogen-containing ionenes. The synthesized linear ionenes react with heparin and polyacrylic acid yielding water-insoluble polyelectrolyte complexes.

  DOI：

  10.1134/s0012500815120034

文献信息

• Phosphorylation of Furfural by Secondary Phosphine Oxides
  作者：N. I. Ivanova、N. K. Gusarova、E. A. Nikitina、S. A. Medvedeva、M. L. Al'pert、B. A. Trofimov

  DOI：10.1023/b:cohc.0000033532.63331.2c

  日期：2004.4
• Gusarova; Trofimov; Malysheva, Russian Journal of General Chemistry, 1997, vol. 67, # 1, p. 65 - 71
  作者：Gusarova、Trofimov、Malysheva、Shaikhudinova、Belogorlova、Arbuzova、Nepomnyashchikh、Dmitriev

  DOI：——

  日期：——
• Gusarova, N. K.; Trofimov, B. A.; Malysheva, S. F., Russian Journal of General Chemistry, 1993, vol. 63, # 1.1, p. 38 - 42
  作者：Gusarova, N. K.、Trofimov, B. A.、Malysheva, S. F.、Arbuzova, S. N.、Shaikhudinova, S. I.、et al.

  DOI：——

  日期：——
• Directed synthesis of tertiary phosphine chalcogenides with pyridine and hydroxy functions
  作者：N. I. Ivanova、P. A. Volkov、N. K. Gusarova、L. I. Larina、B. A. Trofimov

  DOI：10.1134/s1070363211020071

  日期：2011.2

  Secondary phosphine chalcogenides react with pyridine-2-, pyridine-3-, and pyridine-4-carbaldehydes under mild noncatalytic conditions (22-43A degrees C, 1-8.5 h) to form in 81-98% yield functional tertiary phosphine chalcogenides containing pyridine and hydroxy functions.