(7-ethoxy-3-methyl-5,6-dihydroindalozin-8-yl)-phenylmethanone | 477335-92-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (7-ethoxy-3-methyl-5,6-dihydroindalozin-8-yl)-phenylmethanone
• 英文别名: (7-Ethoxy-3-methyl-5,6-dihydroindolizin-8-yl)-phenylmethanone
• CAS: 477335-92-5
• 化学式: C₁₈H₁₉NO₂
• 分子量: 281.354
• InChiKey: UAWRZOBJZMIOFX-UHFFFAOYSA-N

物化性质

• 沸点：
  478.6±45.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (7-ethoxy-3-methyl-5,6-dihydroindalozin-8-yl)-phenylmethanone 在 盐酸 作用下， 生成 (7-hydroxy-3-methyl-5,6-dihydroindalozin-8-yl)-phenylmethanone
  参考文献：
  名称：

  Pyrrolizine and Indolizine Derivatives from 1,6-Dioxo-2,4-diene by Inter- and Intramolecular Ring Closure

  摘要：

  A variety of 1-amino-alkyl esters and nitriles react with 1,6-dioxo-2,4-diene to give pyrrole derivatives in good yield. Mild basic conditions facilitate the further intramoleular Dieckmann or Thorpe like condensation giving pyrrolizine and indolizine derivatives. These reactions provide simple, two step sequence to pyrrolizine and indolizine derivatives with control of product dictated by the base used for the condensation reaction.

  DOI：

  10.3987/com-02-9494
• 作为产物：
  描述：

  beta-丙氨酸乙酯盐酸盐 在 potassium tert-butylate 、 sodium carbonate 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 12.0h， 生成 (7-ethoxy-3-methyl-5,6-dihydroindalozin-8-yl)-phenylmethanone
  参考文献：
  名称：

  Pyrrolizine and Indolizine Derivatives from 1,6-Dioxo-2,4-diene by Inter- and Intramolecular Ring Closure

  摘要：

  A variety of 1-amino-alkyl esters and nitriles react with 1,6-dioxo-2,4-diene to give pyrrole derivatives in good yield. Mild basic conditions facilitate the further intramoleular Dieckmann or Thorpe like condensation giving pyrrolizine and indolizine derivatives. These reactions provide simple, two step sequence to pyrrolizine and indolizine derivatives with control of product dictated by the base used for the condensation reaction.

  DOI：

  10.3987/com-02-9494

文献信息

• Pyrrolizine and Indolizine Derivatives from 1,6-Dioxo-2,4-diene by Inter- and Intramolecular Ring Closure
  作者：Chi-Wi Ong、Ming Chih Lai、Jing Jyh Jan、Yu An Chang

  DOI：10.3987/com-02-9494

  日期：——

  A variety of 1-amino-alkyl esters and nitriles react with 1,6-dioxo-2,4-diene to give pyrrole derivatives in good yield. Mild basic conditions facilitate the further intramoleular Dieckmann or Thorpe like condensation giving pyrrolizine and indolizine derivatives. These reactions provide simple, two step sequence to pyrrolizine and indolizine derivatives with control of product dictated by the base used for the condensation reaction.